Science has a long article detailing the problems that have developed over the last few years in the whole siturin story. That’s a process that I’ve been following here as well (scrolling through this category archive will give you the tale), but this is a different, more personality-driven take. The mess is big enough to warrant a long look, that ‘s for sure:
“. . .The result is mass confusion over who’s right and who’s wrong, and a high-stakes effort to protect reputations, research money, and one of the premier theories in the biology of aging. It’s also a story of science gone sour: Several principals have dug in their heels, declined to communicate, and bitterly derided one another. . .”
As the article shows, one of the problems is that many of the players in this drama came out of the same lab (Leonard Guarente’s at MIT), so there are issues even beyond the usual ones. Mentioned near the end of the article is the part of the story that I’ve spent more time on here, the founding of Sirtris and its acquisition by GlaxoSmithKline. It’s safe to say that the jury is still out on that one – from all that anyone can tell from outside, it could still work out as a big diabetes/metabolism/oncology success story, or it could turn out to have been a costly (and arguably preventable) mistake. There are a lot of very strongly held opinions on both sides.
Overall, since I’ve been following this field from the beginning, I find the whole thing a good example of how tough it is to make real progress in fundamental biology. Here you have something that is (or at the very least has appeared to be) very interesting and important, studied by some very hard-working and intelligent people all over the world for years now, with expenditure of huge amounts of time, effort, and money. And just look at it. The questions of what sirtuins do, how they do it, and whether they can be the basis of therapies for human disease – and which diseases – are all still the subject of heated argument. Layers upon layers of difficulty and complexity get peeled back, but the onion looks to be as big as it ever was.
I’m going to relate this to my post the other day about the engineer’s approach to biology. This sort of tangle, which differs only in degree and not in kind from many others in the field, illustrates better than anything else how far away we are from formalism. Find some people who are eager to apply modern engineering techniques to medical research, and ask them to take a crack at the sirtuins. Or the nuclear receptors. Or autoimmune disease, or schizophrenia therapies. Turn ’em loose on one of those problems, come back in a year, and see what color their remaining hair is.