I wanted to mention that the Chemical Probes portal (mentioned here last summer) has been re-launched with more features, more information (and more funding!) What it needs are more probes in its database. I’ve been submitting some suggestions this morning based on some of my own past experiences, and I invite others to do the same.
One feature that would be controversial but useful would be a list of nonrecommended chemical probes – things that are in the literature or sold by vendors but are definitely not selective enough to be useful (as opposed to the ones where not enough evidence exists either way). There’s a depressingly long list of those, and a rogue’s gallery would be welcome.
An update from Amy Donner at the site (via the comments section here): “. . .we plan to expand the number of probes on the portal as quickly as we can while also ensuring the quality of the curated data associated with a probe as well as providing expert recommendations about the quality of and best use of the probe. We are opening the site up for new submissions as we speak, and plan a series of targeted campaigns (where we solicit probe submissions by protein family) as well as accepting probe submissions as they come in. We are working with several publishers to try and capture new probes as they are published.”