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Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    Cellular Rejuvenation, For Real

    There’s been a good amount of coverage of this paper, which is certainly worth a read. It concerns the “Yamanaka factors”, four proteins whose expression seems to be key for induced pluripotent stem cells and many other cellular programs besides. This latest work shows that cyclic expression of these in adult (indeed, elderly) rod… Read More
  • Aging and Lifespan

    Isotopes, Get Your Revivifying Isotopes

    Here’s your chance to get in on the ground floor – at least, the ground floor of a pitch you probably haven’t heard before. The chemists and biologists in the crowd will be familiar with how isotopic enrichment takes place in biological systems. Bonds between heavier atoms are slightly harder to break, making the rate constants… Read More
  • Aging and Lifespan

    A Shady Trial?

    The “young blood” research field is moving right along, but there are reasons to wonder about some of the directions it’s moving in. I’m referring, of course, to the results that have shown profound effects of younger plasma on older animals, and the big question is what the effects are on older humans. The Stanford… Read More
  • Aging and Lifespan

    Subtle Changes Can Be Yours, for Fifty Dollars a Month

    Several people have sent me a link to Elysium Health, and I can’t say that it’s improved my morning. This is a supplement company founded by (among others) Leonard Guarente of MIT, who is of course well-known for his work in the study of longevity and aging. The company advertises a large and impressive board of… Read More
  • Aging and Lifespan

    The Samumed Story

    Biopharma can be a weird place. Breakthroughs happen, although not as often as the press releases would have everyone believe, and we certainly don’t always see them coming. So when word comes of some amazing new therapy, you can’t dismiss it out of hand, because amazing new therapies do arrive from time to time, and… Read More
  • Aging and Lifespan

    A Nobel for DNA Repair

    This year’s Nobel Prize in Chemistry goes to Tomas Lindahl of the Crick Institute, Paul Modrich of Duke/Howard Hughes Medical Institue and Aziz Sancar of UNC – Chapel Hill, for mechanisms of DNA repair. Here’s the press release, and here (PDF) is the detailed scientific background from the Nobel committee. This is not a prize th… Read More
  • Aging and Lifespan

    The First Real Anti-Aging Trial in Humans

    I’ve mentioned the proposed clinical trial with metformin as a general anti-aging therapy. Here’s a profile of Nir Barzilai, the principle investigator for it. Choosing metformin was as much about going in with a drug that has a very clean safety profile as anything else: “There’s nothing we don’t know about metformin,” Barzilai… Read More
  • Aging and Lifespan

    Young Blood, Revisited

    Here’s an update on the state of those studies that showed that infusing blood of younger animals into olders ones reversed some effects of again. Human studies are underway – small, but worth keeping an eye on – from a startup out of Stanford called Alkahest. Their website isn’t really even running yet, but maybe… Read More
  • Aging and Lifespan

    Another Longevity Target

    Add another potential target to the longevity list: this paper in Cell (open access, actually) provides evidence that the well-known Ras-ERK-ETS pathway is also involved in lifespan. This is work in Drosophila, which is one of the usual places to look for this sort of thing. Figure 6 in the paper proposes a way to… Read More
  • Aging and Lifespan

    Aging As a Disease

    I’ve mentioned numerous times around here that therapies directed against aging in general have a rough regulatory outlook. The FDA, in general, has not considered aging a disease by itself, but rather the baseline against which disease (increasingly) appears. This has meant that companies with ideas for anti-aging therapies have had to work… Read More
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