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Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    A Young Blood Controversy

    The recent revival of interest in the way that the blood from younger animals (and people?) can improve the health of older ones came bundled with a particular protein candidate for the effect, GDF11. Several papers appeared on its effects in vivo, but there were people who found that odd, according to Nature News. Those… Read More
  • Aging and Lifespan

    Metformin for Aging in General?

    Here’s an interesting report in the Wall Street Journal on plans to run a large clinical trial with metformin. That compound has a lot of effects, and many of them seem as if they could be beneficial in an aging population. Dr. Barzilai expects to enroll more than 1,000 elderly participants in the randomized, controlled… Read More
  • Aging and Lifespan

    Rapamycin And Aging: The Spotlight Shines

    Rapamycin gets the spotlight in Bloomberg Businessweek here. This is a look at what’s been set in motion by the 2009 report that the compound notably extended the life of rodents in long-term feeding studies. It’s a good article, and gets some interesting quotes from Mark Fishman of Novartis and many others. One of the… Read More
  • Aging and Lifespan

    Ibuprofen For a Longer Life?

    Here’s one that I didn’t expect: a report that ibuprofen extends lifespan in model organisms. Here we show that ibuprofen increased the lifespan of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster, indicative of conserved eukaryotic longevity effects. Studies in yeast indicate that ibuprofen destabilizes the… Read More
  • Aging and Lifespan

    Google’s Calico Moves Into Reality

    Google’s Calico venture, the company’s out-there move into anti-aging therapy, has made the news by signing a deal with AbbVie (the company most of us will probably go on thinking of as Abbott). That moves them into the real world for sure, from the perspective of the rest of the drug industry, so it’s worth… Read More
  • Aging and Lifespan

    Young Blood

    Anti-aging studies, when they make the news, fall into three unequal categories. There’s a vast pile of quackery, which mercifully isn’t (for the most part) newsworthy. There are studies whose conclusions are misinterpreted by some reporters, or overblown by one party or another. And there’s a small cohort of really interesting st… Read More
  • Aging and Lifespan

    A Sirtuin Activator Extends Lifespan in Normal Mice

    If you haven’t seen it, the Sinclair group and numerous co-workers at the NIH and elsewhere now report that the SIRT1 activator SRT1720 extends the lifespan of mice on a diet of normal chow, and they see a number of good metabolic indicators – increase fat oxidation, decrease fat mass, increased insulin sensitivity, and so… Read More
  • Aging and Lifespan

    Boost Your NAD And Fix It All?

    Here’s a paper from a few weeks back that I missed during the holidays: work from the Sinclair labs at Harvard showing a new connection between SIRT1 and aging, this time through a mechanism that no one had appreciated. I’ll appreciate, in turn, that that opening sentence is likely to divide its readers into those… Read More
  • Aging and Lifespan

    Google Versus Aging

    If you haven’t heard that Google is now funding research into human aging and lifespan, they’ll be very disappointed. There’s been plenty of publicity, which I find sort of interesting, considering that there’s not too much to announce: The Time article—and a Google blog post released at the same time—provided scant deta… Read More
  • Aging and Lifespan

    A New Pathway For Memory

    As someone who will not be seeing the age of 50 again, I find a good deal of hope in a study out this week from Eric Kandel and co-workers at Columbia. In Science Translational Medicine, they report results from a gene expression study in human brain samples. Looking at the dentate gyrus region of… Read More
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