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Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    How Rapamycin Extends Lifespan: Not By Slowing Down Aging

    A few years ago, there came the interesting news that rapamycin looked as if it prolonged lifespan in mice. That result is robust; it’s been replicated. Now a large multicenter effort in Germany has looked closely at this effect, and they have many more details about what’s going on. The big question is: does rapamycin… Read More
  • Aging and Lifespan

    Resveratrol: What’s It Do For Mitochondria?

    I’ve been meaning to blog about this new paper in PLOS Biology on resveratrol’s effects on mitochondria. It’s suggesting that the results previously reported in this area cannot be reproduced, namely the idea that resveratrol increases mitochondrial biogenesis and running endurance. In fact, says this new paper, the whole mechanis… Read More
  • Aging and Lifespan

    A New Book on Longevity Research

    The University of Chicago Press has sent along a copy of a new book by DePaul professor Ted Anton, The Longevity Seekers. It’s a history of the last thirty years or so of advances in understanding the biochemical pathways of aging. As you’d imagine, much of it focuses on sirtuins, but many other discoveries get… Read More
  • Aging and Lifespan

    New Sirtuin Inhibitors

    And since that last post was about sirtuins, here’s a new paper in press at J. Med. Chem. from the Sirtris folks (or the Sirtris folks that were, depending on who’s making the move down to PA). They report a number of potent new sirtuin inhibitor compounds, which certainly do look drug-like, and there are… Read More
  • Aging and Lifespan

    Resveratrol Gets Some Details Cleared Up

    I’ve been meaning to write on this paper, from David Sinclair and co-workers, on the mechanism of resveratrol action. The backstory is so long and convoluted that you’re going to have to set aside some time to catch up if you’re just joining it (paging back through this category archive will give you some play-by-play). Read More
  • Aging and Lifespan

    Caloric Restriction Flops?

    Nature is out today with a paper on the results of a calorie-restriction study that began in 1987. This one took place with rhesus monkeys at the National Institute of Aging, and I’ll skip right to the big result: no increase in life span. That’s in contrast to a study from 2009 (also in rhesus) Read More
  • Aging and Lifespan

    Update on the Buckyball Longevity Paper

    You’ll remember the life-extending fullerenes paper that I blogged about here, and the various problems with it that sharp-eyed readers here spotted. (These drew comments from the lead author here and here). Now the journal has issued a correction that covers some of these issues, along with the following Editor’s Note: It should be not… Read More
  • Aging and Lifespan

    One More on That Buckyball Longevity Paper

    I’ve received another e-mail from Prof. Fathi Moussa, lead author of the C60 longevity paper that’s been discussed around here. I’d sent a list of the critiques that had shown up in the comments sections, and here’s the reply: An erratum with the right figures 3 and 4 will be published soon in Biomaterials. The… Read More
  • Aging and Lifespan

    Buckyball Longevity: The Lead Author Replies

    I’ve received a reply from Dr. Fathi Moussa at Université Paris-Sud, lead author of the C60 longevity paper that I blogged about here, which turned out to have a duplicated figure. With permission, here are the main points of the e-mail: Of course, you are right: in the published figure 4 the GAog and GAip… Read More
  • Aging and Lifespan

    Resveratrol Explained. A Little Bit.

    There’s a new paper out in Cell Metabolism on resveratrol and SIRT1, and the press release from Elsevier (Cell Press) is just a tiny bit optimistic. “Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill”, says the headline, but believe me, no one paper is going to do that. (This entry… Read More
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