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Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    mINDY Mice – No Obesity, No Diabetes?

    Caloric restriction increases healthy lifespan. That’s true in a range of organisms, and probably in humans. But it’s never going to be popular – and what’s more, it’s not going to be feasible, either, given how clearly people like to eat. So the search has been on for just how it exerts its effects, with… Read More
  • Aging and Lifespan

    Live Long and Prosper (and Be Bright Yellow at the Same Time)

    I’ll freely admit to being very interested in research on aging and lifespan. It’s a great subject from a scientific (and philosophical) point of view, but perhaps the prospect of turning 50 years old next year has something to do with it, too (not that that age seems anywhere near believable from my end). Model… Read More
  • Aging and Lifespan

    Resveratrol (SRT501): Development Halted

    Back in May, GlaxoSmithKline halted a trial of SRT501, which is a formulation of resveratrol, in myeloma. Now the folks at the Myeloma Beacon site are the first with the news that the company has halted all further development: According to a GlaxoSmithKline spokesperson, an internal analysis of the kidney failure cases has concluded that… Read More
  • Aging and Lifespan

    Dapsone Prolongs Life? Well, In Nematodes It Does. . .

    Get ready for the life-extension folks to jump on this one: there’s a report out in PNAS that the longtime treatment for leprosy (Hansen’s disease), diaminodiphenylsulfone (DDS or dapsone), also prolongs life in the nematode C. elegans. We seem to be talking about nematodes a lot around here recently. The authors of the current study… Read More
  • Aging and Lifespan

    Does Resveratrol Really Work? And Does SRT1720?

    You’ll recall that we recently had the flap over two GSK/Sirtris executives running their own sideline business selling resveratrol as a dietary supplement. There’s a lot of it out there, understandably, since the publicity around the compound has been intense for several years now. But even if it works, how likely is it that a… Read More
  • Aging and Lifespan

    GSK’s Response to the Sirtuin Critics

    OK, time (finally) for the latest chapter in the GSK-Sirtris saga. (This is going to get fairly geeky, so feel free to skip ahead if you’re not into enzymology). You’ll recall from previous installments that Amgen and Pfizer, among others, had disputed whether the reported sirtuin compounds worked the way that had originally been report… Read More
  • Aging and Lifespan

    Resveratrol (SRT501): Buy Now – Why Wait?

    Update – see below for more on this story. GSK has reacted quickly. . . Now this seems rather odd. According to Xconomy, two former Sirtris higher-ups have formed a nonprofit foundation which is selling resveratrol online. Michelle Dipp, a Sirtris-turned-Glaxo executive, confirmed that the nonprofit that she and former Sirtris CEO Christoph W… Read More
  • Aging and Lifespan

    The Memory Goes Because. . .the Acetyl Groups Go?

    I’ve been meaning to write about this paper from a recent issue of Science. They’ve been studying the differences between young (3-month) mice and old (16-month) mice – their ability to learn, and to remember. Markers of neuronal plasticity and the like are pretty similar between the groups, although the older mice definitely show… Read More
  • Aging and Lifespan

    SRT501 – A Trial Suspended

    A comment to this post on the Sirtris compound saga just had me checking Clinicaltrials.gov. And indeed the commenter is correct: a trial against myeloma of a combination of Velcade (bortezomib) and SRT501, which I believe is reformulated resveratrol itself, was suspended as of April 22 for “unexpected safety concerns”. There’s no… Read More
  • Aging and Lifespan

    The Scent of Food Is Enough?

    Here’s something I never knew: odors can regulate lifespan. Well, in fruit flies, anyway – a group at Baylor published results in 2007 showing that exposure to food-derived odors (yeast smells, in the case of Drosophila) partially cancels out the longevity-inducing effects of caloric restriction. Normally fed flies showed no effect. Tha… Read More
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