Skip to Content

Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    Caloric Restriction and Lifespan – Without the Caloric Restriction?

    If there’s one thing that study-of-aging researchers can agree on, it’s that caloric restriction seems to prolong lifespan in a number of different organisms. The jury is still out on whether this extends all the way up to humans – people are giving it a try, with varying degrees of dedication and experimental rigor, but… Read More
  • Aging and Lifespan

    What Exactly Does Resveratrol Do?

    Resveratrol’s a mighty interesting compound. It seems to extend lifespan in yeast and various lower organisms, and has a wide range of effects in mice. Famously, GlaxoSmithKline has expensively bought out Sirtris, a company whose entire research program started with resveratrol and similar compound that modulate the SIRT1 pathway. But does it… Read More
  • Aging and Lifespan

    A Nobel for Telomerase

    As many had expected, a Nobel Prize has been awarded to Elizabeth Blackburn (of UCSF), Carol Greider (of Johns Hopkins), and Jack Szostak (of Harvard Medical School/Howard Hughes Inst.) for their work on telomerase. Blackburn had been studying telomeres since her postdoc days in the late 1970s, and she and Szostak worked together in the… Read More
  • Aging and Lifespan

    mTOR, Rapamycin, and Lifespan: A Startling Study

    A new paper coming out in Nature is getting a lot of attention, and well it should. This is some of the more dramatic anti-aging news that’s been reported to date. (The accompanying editorial is also surely the first time anyone’s quoted “Stairway to Heaven” in Nature). The work hinges on a kinase enzyme called… Read More
  • Aging and Lifespan

    Exercise and Vitamins: Now, Wait A Minute. . .

    Now, this is an example of an idea being followed through to its logical conclusion. Here’s where we start: the good effects of exercise are well known, and seem to be beyond argument. Among these are marked improvements in insulin resistance (the hallmark of type II diabetes) and glucose uptake. In fact, exercise, combined with… Read More
  • Aging and Lifespan

    Resveratrol in Mice

    Since it’s a favorite topic of mine, I really have to point out this study in PLoS ONE on resveratrol. A large collaboration looked at the gene transcription effects of dosing the compound in mice, compared to a normal diet and to a calorie-restricted one. I can’t do better than the first paragraph of the… Read More
  • Aging and Lifespan

    Why Buy, Anyway?

    I don’t want to say that this is a trend, but I notice that GSK is saying that they’re going to leave Sirtris more or less alone as well (as Takeda has said they’ll do with Millennium). The researchers in both shops should feel good about that, and not only because they’ll be keeping their… Read More
  • Aging and Lifespan

    $720 Million Worth of Sirtuin Research

    Well, I’m back from a brief vacation, and catching up with the news. It looks like the big headline is GlaxoSmithKline’s offer for Sirtris: $720 million, which is a hefty premium (84%!) to what the company was trading for previously. Reckless waste of money, or canny deal? I lean toward the latter, but I’ve long… Read More
  • Aging and Lifespan

    Breaking the Contract of Aging

    Update: Prof. de Grey responds to Jim Hu’s criticisms below I didn’t note it at the time here, but back in November there was a very interesting paper in Nature that bears on aging and life extension. A group at the Hutchinson Center in Seattle did a survey of compounds, looking for whatever might show… Read More
  • Aging and Lifespan

    More Sirtuins With More Effects

    It’s been a while since I talked about sirtuins, but the field has not been quiet. The latest data is a paper in Cell which set off a strong move in the stock of Sirtris, the company closely tied to the labs involved. SIRT1 had already been the focus of a huge amount of attention… Read More
...678