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Posts tagged with "Alzheimer’s Disease"

  • Alzheimer's Disease

    Bexarotene for Alzheimer’s

    Here’s another intriguing Alzheimer’s result, in a field that could certainly use some. A group at Case Western (no, not the gyre guy) has reported on the effects of the RXR ligand Bexarotene (brand name Targretin) in several different mouse models of the disease. Dosing with the compound seems to quickly lower the levels of… Read More
  • Alzheimer's Disease

    Tau Spreads On Its Own?

    I’ve been meaning to mention the very interesting work that’s shown up on tau protein in Alzheimer’s. That’s generally taken a back seat to amyloid in the protein-pathologies-of-Alzheimer’s derby, but no one has been able to rule it out as a causative event, either. And the progress of tau pathology through the brain i… Read More
  • Alzheimer's Disease

    Bernard Munos Rides Again

    I’ve been meaning to link to Matthew Herper’s piece on Bernard Munos and his ideas on what’s wrong with the drug business. Readers will recall several long discussions here about Munos and his published thoughts (Parts one, two, three and four). A take-home message: So how can companies avoid tossing away billions on medicines tha… Read More
  • Alzheimer's Disease

    Alzheimer’s: The News Is Not Getting Better

    Is there something going on with patients in Alzheimer’s trials that we didn’t expect? There have been reports of an unexpected side effect (vasogenic edema) in several trials, for drugs that work through completely different mechanisms. It makes some sense in the case of antibody-based therapies like bapineuzumab (where this problem fi… Read More
  • Alzheimer's Disease

    Alzheimer’s: Down With Amyloid?

    Here’s a fascinating short interview with Mark Smith of Case Western, a leading anti-amyloid-hypothesis guy in the Alzheimer’s field. As you’d imagine, he’s taking the recent failure of Lilly’s gamma-secretase inhibitor in stride. As you might imagine, he’s not shy: “Everything comes down to how one interpr… Read More
  • Alzheimer's Disease

    Lilly’s Gamma Secretase Inhibitor for Alzheimer’s: Worse Than Nothing

    Well, well, well. We finally have solid clinical data from a large trial of a gamma-secretase inhibitor for Alzheimer’s disease. And it doesn’t work. Background, for those outside the field: a hallmark of Alzheimer’s is the appearance of plaques in the brain. These are insoluble clumps of a protein called amyloid-beta, surrounded… Read More
  • Alzheimer's Disease

    Alzheimer’s Markers and Collaboration

    I’m of two minds on this New York Times article on Alzheimer’s research. It details some recent progress on biomarkers for the disease, and that work does look to be useful. A lot of people have proposed diagnostics and markers for Alzheimer’s and its progression over the years, but none of them have really panned… Read More
  • Alzheimer's Disease

    Alzheimer’s and Amyloid, Again

    I wanted to mention this good article in the New York Times on the amyloid hypothesis and Alzheimer’s. That’s a topic I’ve covered often here, but this is a good overview of the field. And it’s a good overview of the field’s big questions, too: is amyloid really the cause of Alzheimer’s? Do we have… Read More
  • Alzheimer's Disease

    Alzheimer’s: Extracting Data From Failed Trials

    It’s no secret that Alzheimer’s disease has been a disastrous area in which to do drug discovery. Every large drug company has had failures in the area, and many smaller ones have gone out of business trying their hands. (I had several years in the field myself earlier in my career, trying three different approaches… Read More
  • Aging and Lifespan

    The Memory Goes Because. . .the Acetyl Groups Go?

    I’ve been meaning to write about this paper from a recent issue of Science. They’ve been studying the differences between young (3-month) mice and old (16-month) mice – their ability to learn, and to remember. Markers of neuronal plasticity and the like are pretty similar between the groups, although the older mice definitely show… Read More