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Posts tagged with "Alzheimer’s Disease"

  • Alzheimer's Disease

    Alzheimer’s: The News Is Not Getting Better

    Is there something going on with patients in Alzheimer’s trials that we didn’t expect? There have been reports of an unexpected side effect (vasogenic edema) in several trials, for drugs that work through completely different mechanisms. It makes some sense in the case of antibody-based therapies like bapineuzumab (where this problem fi… Read More
  • Alzheimer's Disease

    Alzheimer’s: Down With Amyloid?

    Here’s a fascinating short interview with Mark Smith of Case Western, a leading anti-amyloid-hypothesis guy in the Alzheimer’s field. As you’d imagine, he’s taking the recent failure of Lilly’s gamma-secretase inhibitor in stride. As you might imagine, he’s not shy: “Everything comes down to how one interpr… Read More
  • Alzheimer's Disease

    Lilly’s Gamma Secretase Inhibitor for Alzheimer’s: Worse Than Nothing

    Well, well, well. We finally have solid clinical data from a large trial of a gamma-secretase inhibitor for Alzheimer’s disease. And it doesn’t work. Background, for those outside the field: a hallmark of Alzheimer’s is the appearance of plaques in the brain. These are insoluble clumps of a protein called amyloid-beta, surrounded… Read More
  • Alzheimer's Disease

    Alzheimer’s Markers and Collaboration

    I’m of two minds on this New York Times article on Alzheimer’s research. It details some recent progress on biomarkers for the disease, and that work does look to be useful. A lot of people have proposed diagnostics and markers for Alzheimer’s and its progression over the years, but none of them have really panned… Read More
  • Alzheimer's Disease

    Alzheimer’s and Amyloid, Again

    I wanted to mention this good article in the New York Times on the amyloid hypothesis and Alzheimer’s. That’s a topic I’ve covered often here, but this is a good overview of the field. And it’s a good overview of the field’s big questions, too: is amyloid really the cause of Alzheimer’s? Do we have… Read More
  • Alzheimer's Disease

    Alzheimer’s: Extracting Data From Failed Trials

    It’s no secret that Alzheimer’s disease has been a disastrous area in which to do drug discovery. Every large drug company has had failures in the area, and many smaller ones have gone out of business trying their hands. (I had several years in the field myself earlier in my career, trying three different approaches… Read More
  • Aging and Lifespan

    The Memory Goes Because. . .the Acetyl Groups Go?

    I’ve been meaning to write about this paper from a recent issue of Science. They’ve been studying the differences between young (3-month) mice and old (16-month) mice – their ability to learn, and to remember. Markers of neuronal plasticity and the like are pretty similar between the groups, although the older mice definitely show… Read More
  • Alzheimer's Disease

    A Brief and Not At All Intemperate Evaluation of the Current Literature

    In keeping with my Modest Literature Proposal from earlier this year, I would like to briefly point out a Journal of Medicinal Chemistry paper on potential Alzheimer’s therapies. Whose lead compound has a nine-carbon alkyl chain in the middle of it. And weighs 491. And has two quaternary nitrogens. Which structural features will, in all… Read More
  • Aging and Lifespan

    Rapamycin for Alzheimer’s?

    Last summer a paper was published (PDF) showing rapamycin dosing appeared to lengthen lifespan in mice. (In that second link, I went more into the background of rapamycin and TOR signaling, for those who are interested). Now comes word that it also seems to prevent cognitive deficits in a mouse model of Alzheimer’s. The PDAPP… Read More
  • Alzheimer's Disease

    Beta-Amyloid: An Antibiotic?

    Now here’s something that I don’t think anyone expected. A recent paper in PLoS One makes the case that beta-amyloid, the protein that has been fingered for decades as a major player in Alzheimer’s disease, is actually part of the body’s antimicrobial defenses. Well, it’s good to hear that it’s doing something. M… Read More
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