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Posts tagged with "Alzheimer’s Disease"

  • Aging and Lifespan

    Rapamycin for Alzheimer’s?

    Last summer a paper was published (PDF) showing rapamycin dosing appeared to lengthen lifespan in mice. (In that second link, I went more into the background of rapamycin and TOR signaling, for those who are interested). Now comes word that it also seems to prevent cognitive deficits in a mouse model of Alzheimer’s. The PDAPP… Read More
  • Alzheimer's Disease

    Beta-Amyloid: An Antibiotic?

    Now here’s something that I don’t think anyone expected. A recent paper in PLoS One makes the case that beta-amyloid, the protein that has been fingered for decades as a major player in Alzheimer’s disease, is actually part of the body’s antimicrobial defenses. Well, it’s good to hear that it’s doing something. M… Read More
  • Alzheimer's Disease

    Dimebon, Grasping at Straws

    Robert Langreth, an editor at Forbes, points to a possible way that Dimebon could get approval for Alzheimer’s: for its behavioral effects, not anything to do with amyloid or memory. I’m not buying it, I have to say. Even Langreth’s source admits that behavioral numbers didn’t reach statistical significance. I don’t se… Read More
  • Alzheimer's Disease

    Dimebon Comes Crashing to Earth

    Earlier this month I wrote about Medivation and their Russian-derived clinical candidate for Alzheimer’s disease, Dimebon (latrepirdine). At the time, I wrote that “A lot of eye-catching numbers from small Phase II trials tend to flatten out in the wider world of Phase III, and if forced, that’s the way I’d bet here.”… Read More
  • Alzheimer's Disease

    A Modest Literature Proposal

    Looking through the latest papers to show up in the Journal of Medicinal Chemistry, this one on BACE-1 inhibitor compounds caught my eye. Perhaps I’m about to be unfair to it. At any rate, I’m going to ask of it something it doesn’t provide: data in something that’s alive. Doesn’t have to be a person… Read More
  • Alzheimer's Disease

    Dimebon for Alzheimer’s: A Black Box Indeed

    Dimebon (dimebolin) is a perfect example of the black-box nature of drug research for the central nervous system. Any medicinal chemist who looks at its structure would immediately say “CNS”, but shrug when asked what specific receptors it might hit. I’d have guessed histamine (correctly), since loratidine used to pay my salary, a… Read More
  • Alzheimer's Disease

    Two Doses of Crazy

    I’d like to take the time this morning to deal with two conspiracy theorists, and I’ll take them in order of increasing foil-hat thickness. First up is Joe Collier, an emeritus professor who writes a blog for the British Medical Journal. He notes the recent study that suggested that cell phone emissions could have a… Read More
  • Alzheimer's Disease

    An Alzheimer’s Compound Runs Into Big Trouble

    Another interesting approach to Alzheimer’s therapy has just taken a severe jolt in the clinic. Elan and Transition Therapeutics were investigating ELEND005, also known as AZD-103, which was targeted at breaking down amyloid fibrils and allowing the protein to be cleared from the brain. Unfortunately, the two highest-dose patient groups exper… Read More
  • Academia (vs. Industry)

    Short Topics From All Over

    (1) Bnet Pharma on “How Not to Write a Pharma Press Release“. Privately held Epeius is sending out bulletins loaded with phrases like “more stunning results” and “Epeius Biotechnologies draws the sword of targeted gene delivery from the stone of chemistry and physics”. If they were publicly traded, this would be… Read More
  • Alzheimer's Disease

    Amyloid in Trouble

    Here’s an interesting look at the current state of the Alzheimer’s field from Bloomberg. The current big hope is Wyeth (and Elan)’s bapineuzumab, which I last wrote about here. That was after the companies reported what had to be considered less-than-hoped-for efficacy in the clinic. The current trial is the one sorted out by APOE… Read More
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