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  • ApoE4: Test or Not?

    Science has coverage of a diagnostic test for the APOE gene that’s coming into the market. For about $400, you can find out what form of the protein you have. Read More
  • Fast Plaques in a Slow Disease

    One of the first projects I ever worked on when I started in industry was targeting Alzheimer’s disease. Things could have easily worked out to find me st… Read More
  • Beta-Secretase: Not So Fast?

    (My apologies for no update today – it’s been hectic around here, for reasons that I hope to be able to reveal soon). Some of the first work I did i… Read More
  • A Trial Too Far

    So Johnson and Johnson is the latest company to try to broaden their market for a drug and run into cardiovascular side effects. Their Alzheimer’s drug Re… Read More
  • Gumming Up the Amyloid Works

    The October 29th issue of Science has an interesting article from a team at Stanford on a possible approach for Alzheimer’s therapy. The dominant Alzheime… Read More
  • Silent Mutations and Noisy Ones

    One of the comments in my post on animal models prompts me to write a bit more on mutations. I stated that the mutant animal models that we use all have somethi… Read More
  • Back on the Air

    After a (reasonably) refreshing holiday break, Lagniappe is back. Thanks to everyone who kept doggedly hitting this site during the last few days – I admi… Read More
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