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Posts tagged with "Alzheimer’s Disease"

  • Alzheimer's Disease

    Failure: Not Your Friend, But Definitely Your Companion

    Here’s something that you don’t see discussed very often, but it’s worth some thought: what kind of personality do you need to have to do drug discovery research? Clearly, any conclusions are going to carry over well to other fields, but drug work has some peculiarities that can’t be ignored. The most obvious one is… Read More
  • Alzheimer's Disease

  • Alzheimer's Disease

    A Trial Too Far

    So Johnson and Johnson is the latest company to try to broaden their market for a drug and run into cardiovascular side effects. Their Alzheimer’s drug Reminyl (galantamine), makes some money, but is hardly a blockbuster. It’s a natural product (derived from daffodil bulbs, of all things), and it’s a cholinesterase inhibitor, the… Read More
  • Academia (vs. Industry)

    Gumming Up the Amyloid Works

    The October 29th issue of Science has an interesting article from a team at Stanford on a possible approach for Alzheimer’s therapy. The dominant Alzheimer’s hypothesis, as everyone will probably have heard, is that the aggregation of amyloid protein into plaques in the brain is the driving force of the disease. There’s some well- Read More
  • Alzheimer's Disease

    Silent Mutations and Noisy Ones

    One of the comments in my post on animal models prompts me to write a bit more on mutations. I stated that the mutant animal models that we use all have something wrong with them, but I didn’t mean to imply that all mutations will do that. There are plenty of so-called “silent” mutations out… Read More
  • Alzheimer's Disease

    Back on the Air

    After a (reasonably) refreshing holiday break, Lagniappe is back. Thanks to everyone who kept doggedly hitting this site during the last few days – I admire your persistance. I notice from my site’s counter that I get a small but steady flow of Google hits for various miracle cures. I said some nasty things about… Read More
  • Alzheimer's Disease

    Alzheimer’s Vaccine Refuses to Die

    The Alzheimer’s vaccine idea that I’ve covered every so often is back in the news. Two studies coming out in Nature Medicine give it a boost. One shows that the ill-fated Elan clinical trial (which came to a screeching halt when some patients developed brain inflammation) actually did lead to antibody production against the beta-amyloid… Read More
  • Alzheimer's Disease

    Sleeping Dragons

    One of the things that gives me the willies about biochemistry is the nonlinearity. If anyone were to ever come up with a set of equations to model all the ins and outs ofa living organism, there would be all these terms – way out in the boonies of the expression – with things to… Read More
  • Alzheimer's Disease

    Maybe They Can Formulate It in Madelaines

    There’s a report today that an Alzheimer’s medication seems to help memory function even in people who don’t have the disease. As reported in Neurology, pilots using a flight simulator performed better when repeating tasks learned while taking Pfizer’s drug donepezil (Aricept – it’s actually an Eisai drug that Pf… Read More
  • Alzheimer's Disease

    Who Dares, Wins?

    I’d like to take the time to sympathize with Elan Pharmaceuticals over what’s happened to their Alzheimer’s trial. They had the initiative (and the nerve) to pick up and run with an unusual discovery: that a protein that precipitates in the brains of Alzheimer’s patients, beta-amyloid, can be attacked by an immune response.… Read More
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