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  • Silent Mutations and Noisy Ones

    One of the comments in my post on animal models prompts me to write a bit more on mutations. I stated that the mutant animal models that we use all have somethi… Read More
  • Back on the Air

    After a (reasonably) refreshing holiday break, Lagniappe is back. Thanks to everyone who kept doggedly hitting this site during the last few days – I admi… Read More
  • Sleeping Dragons

    One of the things that gives me the willies about biochemistry is the nonlinearity. If anyone were to ever come up with a set of equations to model all the ins… Read More
  • Who Dares, Wins?

    I’d like to take the time to sympathize with Elan Pharmaceuticals over what’s happened to their Alzheimer’s trial. They had the initiative (an… Read More
  • Modeling the Brain?

    That neuroscience business came up, I guess, because I have a minor background in it. I broke into the drug business doing work on schizophrenia, and followed t… Read More
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