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Posts tagged with "Alzheimer’s Disease"

  • Alzheimer's Disease

    Sulfur, Sulfur, Sulfur

    Does anyone know of any phosphatase inhibitors that aren’t hideous? I ask this because someone sent along a question about this paper, from last August, that I’d missed at the time (press release here, but the paper’s open-access as well). Here’s a commentary in the journal itself. It’s work from Yale on an enzyme call… Read More
  • Alzheimer's Disease

    Another Argument For Tau

    Just to give most everyone in the Alzheimer’s field a little more reason to doubt themselves, the Mayo Clinic has published a study suggesting that the pathology associated with tau protein (neurofibrillary tangles, NFT) is (as some have always maintained) more important than that associated with beta-amyloid. Our observations reaffirm the co… Read More
  • Alzheimer's Disease

    Biogen’s Alzheimer’s Data

    If you’re a rabid biotech investor, you already know all about Biogen’s data this morning. If you’re sane, or insane in some other, more interesting direction, then here’s what’s up: last December, the company released some Phase I data suggesting that their amyloid antibody, BIIB037 (aducanumab) was showing better-tha… Read More
  • Alzheimer's Disease

    Gamma-Secretase Inhibitors: The Wrong Way Around?

    Here’s an Alzheimer’s mystery, and that area was not lacking for them before. A paper in Neuron from Harvard/Mass General/Brigham & Women’s says that we may have been thinking about gamma-secretase the wrong way around. (Here’s a press release from Harvard, although I believe the paper is open-access as well). That enzy… Read More
  • Alzheimer's Disease

    New Alzheimer’s Research in the UK

    Oxford University’s new Drug Discovery Institute is making a big push in dementia and Alzheimer’s. Update: link fixed, I hope. One one level, that’s good news, because this is a tough area that needs all the well-placed shots that can be aimed at it. The folks Oxford will be staffing this institute with will surely… Read More
  • Alzheimer's Disease

    “From All This You’d Imagine, That There Must Be Something Learned. . .”

    Eli Lilly’s phase III clinical trial of semagacestat, a gamma-secretase inhibitor, was a notable disaster. The drug did absolutely nothing at all for Alzheimer’s patients – in fact, if anything, it made them slightly worse. The amyloid hypothesis was not illuminated in any useful way by this work – in fact, if anything, the… Read More
  • Alzheimer's Disease

    Another Alzheimer’s Antibody Goes Down

    The clinical failure rate for disease-modifying Alzheimer’s therapies remains perfect, unfortunately: a flat 100%. The latest news is from Roche. Their in-licensed amyloid-targeting antibody (gantenerumab, from MorphoSys) came up empty on an interim trial analysis. Other trials are apparently continuing, but with what hopes? Roche’s rat… Read More
  • Alzheimer's Disease

    Alzheimer’s in Cell Culture?

    While we’re talking about cell culture, there’s some potentially significant news in Alzheimer’s. The Tanzi lab at Mass General is reporting in Nature that they’ve been able to grow 3D neuronal cultures that actually reproduce the plaque-and-tangle symptoms of Alzheimer’s. That’s quite a surprise – neurons… Read More
  • Alzheimer's Disease

    Lilly Steps In for AstraZeneca’s Secretase Inhibitor

    Today brings news of a deal with AstraZeneca to help develop AZ’s beta-secretase inhibitor, AZD3293 (actually an Astex compound, developed through fragment-based methods). AZ has been getting out of CNS indications for some time now, so they really did need a partner here, and Lilly lost their own beta-secretase compound last year. So this mo… Read More
  • Alzheimer's Disease

    TDP-43 and Alzheimer’s

    There are quite a few headlines today about a link between Alzheimer’s and a protein called TDP-43. This is interesting stuff, but like everything else in the neurodegeneration field, it’s going to be tough to unravel what’s going on. This latest work, just presented at a conference in Copenhagen, found (in a large post mortem… Read More
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