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Posts tagged with "Alzheimer’s Disease"

  • Alzheimer's Disease

    Alzheimer’s in Cell Culture?

    While we’re talking about cell culture, there’s some potentially significant news in Alzheimer’s. The Tanzi lab at Mass General is reporting in Nature that they’ve been able to grow 3D neuronal cultures that actually reproduce the plaque-and-tangle symptoms of Alzheimer’s. That’s quite a surprise – neurons… Read More
  • Alzheimer's Disease

    Lilly Steps In for AstraZeneca’s Secretase Inhibitor

    Today brings news of a deal with AstraZeneca to help develop AZ’s beta-secretase inhibitor, AZD3293 (actually an Astex compound, developed through fragment-based methods). AZ has been getting out of CNS indications for some time now, so they really did need a partner here, and Lilly lost their own beta-secretase compound last year. So this mo… Read More
  • Alzheimer's Disease

    TDP-43 and Alzheimer’s

    There are quite a few headlines today about a link between Alzheimer’s and a protein called TDP-43. This is interesting stuff, but like everything else in the neurodegeneration field, it’s going to be tough to unravel what’s going on. This latest work, just presented at a conference in Copenhagen, found (in a large post mortem… Read More
  • Alzheimer's Disease

    Targacept Fumbles the Bad News on Alzheimer’s

    Targacept has been working on some very hard therapeutic areas over the years, and coming up dry – dramatically so. They may have just done it again. They’ve been testing TC-1734 in Alzheimer’s over the last year or so, a partial agonist at nicotinergic receptors. That was a long-shot mechanism to start with, although to… Read More
  • Alzheimer's Disease

    An Alzheimer’s Blood Test? Not So Fast.

    There all all sorts of headlines today about how there’s going to be a simple blood test for Alzheimer’s soon. Don’t believe them. This all comes from a recent publication in the journal Alzheimer’s and Dementia, from a team at King’s College (London) and the company Proteome Sciences. It’s a perfectly good paper… Read More
  • Alzheimer's Disease

    Alzheimer’s Bonds

    I wrote a couple of years ago about Andrew Lo of MIT, and his idea for securitization of drug discovery. For those of you who aren’t financial engineers, that means raising funds by issuing securities (bonds and the like), and that’s something that (as far as I know) has never been used to fund any… Read More
  • Alzheimer's Disease

    Good News! Our Alzheimer’s Drug Didn’t Work!

    Alzheimer’s disease is one of the notorious rocks of drug development. Around it are piles of debris, shipwrecks of clinical research programs large and small. But late last week, as yet another company sailed in close, something new happened. Unfortunately, that may not mean “new” an in “good”. A small company called… Read More
  • Alzheimer's Disease

    Citalopram for Alzheimer’s?

    Here’s a surprise – the well-known antidepressant citalopram appears to decrease formation of beta-amyloid (press release here). There have been some connections reported between serotonin signaling and amyloid production, but this makes it rather explicit. The paper not only reports rodent data, but shows human levels of beta-amyloid w… Read More
  • Alzheimer's Disease

    Alzheimer’s Antibodies: Can the Current Ones Even Work?

    As everyone in the field knows, there’s a lot of work that has been poured into anti-beta-amyloid antibodies as a potential therapy for Alzheimer’s. There are plenty of questions, starting with the amyloid hypothesis itself, but even if you stipulate that, the question that this paper asks is key: do these antibodies engage their target… Read More
  • Alzheimer's Disease

    The State of Alzheimer’s Research, 2014

    Via Bernard Munos on Twitter, here’s a report from the New York Academy of Sciences looking at the current state of Alzheimer’s research. Those various tabs are all live; you can get summaries of each one by clicking. Looking them over breeds a mixture of hope and despair. The whole thing is themed around the… Read More
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