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Posts tagged with "Alzheimer’s Disease"

  • Alzheimer's Disease

    Alzheimer’s Antibodies: Can the Current Ones Even Work?

    As everyone in the field knows, there’s a lot of work that has been poured into anti-beta-amyloid antibodies as a potential therapy for Alzheimer’s. There are plenty of questions, starting with the amyloid hypothesis itself, but even if you stipulate that, the question that this paper asks is key: do these antibodies engage their target… Read More
  • Alzheimer's Disease

    The State of Alzheimer’s Research, 2014

    Via Bernard Munos on Twitter, here’s a report from the New York Academy of Sciences looking at the current state of Alzheimer’s research. Those various tabs are all live; you can get summaries of each one by clicking. Looking them over breeds a mixture of hope and despair. The whole thing is themed around the… Read More
  • Alzheimer's Disease

    A Blood Test for Alzheimer’s?

    Update: more doubts on the statistical power behind this, and the coverage it’s getting in the press. There’s word of a possible early diagnostic blood test for Alzheimer’s. A large team (mostly from Georgetown and Rochester) has published a paper in Nature Medicine on their search for lipid-based markers of incipient disease. The… Read More
  • Alzheimer's Disease

    Alzheimer’s Therapies: A Reasonably Gloomy Update

    The New England Journal of Medicine has publications from Pfizer / J&J and Lilly on their multiple phase III trials of anti-amyloid antibodies (bapineuzumab and solanezumab, respectively). As the world knows, neither of them hit their primary endpoints. How optimistic one can be after that is a matter for fine distinctions. Medscape has a look… Read More
  • Academia (vs. Industry)

    A Reply on Academic Alzheimer’s Research

    One of the authors of a paper I commented on has shown up in the comments section to that post, and I wanted to highlight his reply out here on the front page of the blog. Here’s J. R. Brender, from the Michigan side of the authorship: Hi. I appreciate the comments the given about… Read More
  • Academia (vs. Industry)

    An All-In-One Alzheimer’s Paper

    A reader sent along this paper that’s come out recently in JACS, from a Michigan/South Korea/UCSB team of researchers. It’s directed towards a possible therapeutic agent for Alzheimer’s disease. They’re attempting to build a molecule that binds beta-amyloid, coordinates metals, and has antioxidant properties all at the same… Read More
  • Alzheimer's Disease

    David Cameron, The Press, Alzheimer’s, and Hope

    One should be cheering the news that Great Britain will double funding for Alzheimer’s and dementia research. But there’s something odd about the way it’s being presented, at least to my eyes. Here’s a story from the Guardian that might illustrate what I mean: The health secretary, Jeremy Hunt, said he hoped the dementia sum… Read More
  • Alzheimer's Disease

    Lilly Goes All In on Solanezumab

    So Eli Lilly is going to double down on solanezumab, their antibody treatment for Alzheimer’s that did not show impressive results in earlier trials. The company is going into an even bigger Phase III, with a more carefully selected patient population, in hopes of showing a benefit. Yikes. On one level, I sort of admire… Read More
  • Alzheimer's Disease

    A Beta-Secretase Inhibitor Hits the Skids in Alzheimer’s

    The brutal drumbeat of Alzheimer’s clinical failure continues at Eli Lilly. After the Phase III failure of their gamma-secretase inhibitor semagacestat, and a delusional attempt to pretend that the anti-amyloid antibody solanezumab succeeded, now comes word that the company has halted studies of a beta-secretase inhibitor. This one wasn’… Read More
  • Alzheimer's Disease

    Update on Bexarotene for Alzheimer’s

    Here’s a follow-up on the news that bexarotene might be useful for Alzheimer’s. Unfortunately, what seems to be happening is what happens almost every time that the word “Alzheimer’s” is mentioned along with a small molecule. As Nature reports here, further studies are delivering puzzling results. The original work, fr… Read More
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