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  • Calcium Probe Problems

    Fluorescent dyes and probes are wonderful things, and they have been absolutely crucial to our understanding of cellular biology. Being able to see specific pro… Read More
  • PAINs by X-Ray

    It’s safe to say that the concept of “pan-assay interference compounds” evokes some strong feelings in medicinal chemists. And those feelings… Read More
  • Tickling Individual Bonds

    When you get down to it, most of the ways that we chemists have to make our reactions work are not very elegant. We can change solvents, mess with ligands, drip… Read More
  • Going After Ebola

    How small-molecule drugs fit into binding pockets in their targets is one of the central questions of medicinal chemistry. A new paper from a group at Oxford g… Read More
  • Stereochemical Mysteries, Solved

    Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will… Read More
  • A Rain of Tiny Droplets

    You might be surprised to know how little we chemists know about what our reactions are really doing. A case in point is the “on water” field. Water… Read More
  • A Nobel for Cryo-EM

    The Chemistry Nobel committee seems to have taken everyone by surprise today with their award for cryo-electron microscopy (cryo-EM). That’s not because i… Read More
  • Short Chemistry Topics

    Blogging time is tight today, but there are several interesting stories and follow-ups that I wanted to mention. For starters, I wrote here about a cyclohexane… Read More
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