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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Small Molecule Structures: A New World

    Word has been spreading rapidly about this preprint on Chemrxiv.org, from a joint UCLA/Caltech team. It details the use of the cryo-electron microscopy technique called micro-electron diffraction (MicroED) for the structure determination of small molecules, and it’s absolutely startling. I read it last night, with many exclamations along the… Read More
  • Analytical Chemistry

    Blue Light Coming Out of the NMR

    I really enjoyed this paper from Merck’s Process R&D group, but some readers will be saying “Yeah, but that’s just because you really enjoy photochemistry reactions”. The latter part is true, but it’s the sort of paper that we need to help drain some of the voodoo out of all the exciting photochemistry work that… Read More
  • Analytical Chemistry

    Knowing the Structure

    There are a lot of topics that we really should know more about in drug discovery, but which are buried inside projects inside particular organizations. Some of this knowledge is available once you’re inside said organization, but some of it is hard to assemble even then (much less into a review from outside). An example… Read More
  • Analytical Chemistry

    Sitting There For Five Hundred Million Years

    This paper is really a tour de force of analytical chemistry, because it does something that I didn’t think was possible. The team is looking at a rather ancient creature, Dickinsonia. In fact, you could argue that it’s the ancient creature, since it’s one of the Ediacaran organisms that are part of the first explosion… Read More
  • Analytical Chemistry

    How Close is Cryo-EM To Riding Over the Horizon?

    OK, all this cryo-electron microscopy stuff is great, new protein structures, things that are huge, that can’t be crystallized, fine, fine: but when, the medicinal chemists in the audience ask, will we be able to use it for structure-based drug discovery? This new review tries to answer just that question. The first thing that you… Read More
  • Analytical Chemistry

    Cooling Crystals is Great. Except When It Isn’t.

    If you’ve ever been around an X-ray crystallography setup, one of the constants is a tube directing a blast of chilly vapor at the crystal that’s mounted for analysis. It’s usually a stream of cold nitrogen gas, often set up as a blast of the cold stuff surrounded by a second concentric layer of dry… Read More
  • Analytical Chemistry

    The Entropic Term is Laughing At Us

    There are plenty of things to optimize in a med-chem project other than binding affinity. But if you don’t have at least some level of binding, you may not have a med-chem project. And while from the outside, you might think that understanding how and why compound A binds to a given target while compound… Read More
  • Analytical Chemistry

    Covalent Organic Frameworks

    Let us pause to consider the weirdness of diamond. Not because diamonds are rare – they’re not, at least compared to many other minerals and gemstones. But diamond itself has very unusual physical properties, and that comes down to its structure. As is well known to chemists, it’s a three-dimensional lattice of bonded sp3 carbons… Read More
  • Analytical Chemistry

    The Phosphoproteomic Landscape Speaks – What Did It Say, Again?

    Medicinal chemists are extremely familiar with G-protein coupled receptors (GPCRs), and it’s a safe bet that any pretty much any neurotransmitter (for example) that can be named by the general public is a GPCR ligand, too. Serotonin, dopamine, histamine – all the classics are there, and that’s reflected in the number of marketed d… Read More
  • Analytical Chemistry

    Complex Organics Are Out There – Again

    There’s no way, as a chemist and telescope owner, that I could let this story go by. A new paper reports mass spec data from ice grains that have been sprayed from Saturn’s moon Enceladeus, and let’s just say that there’s a lot of stuff in them. Enceladeus and Europa (a broadly similar moon around… Read More
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