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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    X-Ray Structures Of Everything. Without Crystals. Holy Cow.

    There’s an absolutely startling new paper out from Makoto Fujita and co-workers at the University of Tokyo. I’ve written a number of times here about X-ray crystallography, which can be the most powerful tool available for solving the structures of both large and small molecules – if you can get a crystal, and if that… Read More
  • Analytical Chemistry

    Probing A Binding Tunnel With AFM

    Every so often I’ve mentioned some of the work being done with atomic force microscopy (AFM), and how it might apply to medicinal chemistry. It’s been used to confirm a natural product structural assignment, and then there are images like these. Now comes a report of probing a binding site with the technique. The experimental… Read More
  • Analytical Chemistry

    Single-Cell NMR? How About Single-Protein NMR?

    Two different research teams have reported a completely different way to run NMR experiments, one that looks like it could take the resolution down to cellular (or even large protein) levels. These two papers in Science have the details (and there’s an overall commentary here, and more at Nature News). This is not, as you’ve… Read More
  • Analytical Chemistry

    Stanford’s Free Electron Laser Blasts Away

    Here’s another next-generation X-ray crystal paper, this time using a free electron laser X-ray source. That’s powerful enough to cause very fast and significant radiation damage to any crystals you put in its way, so the team used a flow system, with a stream of small crystals of T. brucei cathepsin B enzyme being exposed… Read More
  • Analytical Chemistry

    Every Tiny Detail

    Via Chemjobber, we have here an excellent example of how much detail you have to get into if you’re seriously making a drug for the market. When you have to account for every impurity, and come up with procedures that generate the same ones within the same tight limits every time, this is the sort… Read More
  • Analytical Chemistry

    Picosecond Protein Watching

    We’re getting closer to real-time X-ray structures of protein function, and I think I speak for a lot of chemists and biologists when I say that this has been a longstanding dream. X-ray structures, when they work well, can give you atomic-level structural data, but they’ve been limited to static time scales. In the old… Read More
  • Analytical Chemistry

    GSK’s Anti-Doping Ad

    Courtesy of a reader in the UK, here’s an ad from GlaxoSmithKline that I don’t think has been seen much on this side of the Atlantic. I hadn’t realized that they were involved in the drug testing for the London games; it’s interesting that their public relations folks feel that it’s worth highlighting. They’re al… Read More
  • Analytical Chemistry

    Bungled Structure, And How

    A lot of natural product structures have been misassigned over the years. In the old days, it was a wonder when you were able to assign a complex one at all. Structure determination, pre-NMR, could be an intellectual challenge at the highest level, something like trying to reconstruct a position on a chess board in… Read More
  • Analytical Chemistry

    Fluorine NMR: Why Not?

    Fluorine NMR is underused in chemistry. Well, then again, maybe it’s not, but it’s one of those thing that just seems like it should have more uses than it does. (Here’s a recent bookon the subject). Fluorine is a great NMR nucleus – all the F in the world is the same isotope, unless you’re… Read More
  • Analytical Chemistry

    An NMR Poster

    Here’s a very nice poster-style presentation of proton NMR and spectral interpretation, courtesy of Jon Chui. I wish I’d had something like it when I was learning the topic, and it’s a very useful way to picture it even for those of us who’ve been taking spectra for years. Recommended. Read More
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