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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    XMRV: It’s Ugly, But That’s Science

    How’s the XMRV / chronic fatigue syndrome connection holding up? Not real well. Science has a roundup of the latest news in the area, and none of it looks encouraging. There are four studies that have come out in the journal Retrovirology that strongly suggest that earlier positive test results for the virus in CFS… Read More
  • Analytical Chemistry

    Detecting Single Cancer Cells

    This story on a new diagnostic method in oncology is getting a lot of attention in the press. It’s a collaboration between J&J, a small company they’ve bought called Veridex, and several oncology centers to see if very sensitive monitoring of circulating tumor cells could be a more useful biomarker. The press coverage has some… Read More
  • Analytical Chemistry

    NASA’s Arsenic Bacteria: A Call For Follow-Up Experiments

    Since the posts here on the possible arsenic-using bacteria have generated so many comments, I’d like to try to bring things together. If you think that the NASA results need shoring up – and a lot of people do, including me – please leave a comment here about what data or new experiments you’d want… Read More
  • Analytical Chemistry

    Enthalpy and Entropy Again

    Earlier this year, I wrote here about using calorimetry in drug discovery. Years ago, people would have given you the raised eyebrow if you’d suggested that, but it’s gradually becoming more popular, especially among people doing fragment-based drug discovery. After all, the binding energy that we depend on for our drug candidates is a… Read More
  • Analytical Chemistry

    The Latest Technology

    Well, the latest for 1960, anyway. That’s the Bruker KIS-1 NMR machine there, folks, operating at 25 MHZ, and ready to dim the lights in the whole building when you switch on that electromagnet. Allow about 12 hours of acquisition time to get a decent spectrum. For those of you outside the field, a 300… Read More
  • Analytical Chemistry

    Chemical Biology: Plastic Antibodies?

    Here’s an interesting example of a way that synthetic chemistry is creeping into the provinces of molecular biology. There have been a lot of interesting ideas over the years around the idea of polymers made to recognize other molecules. These appear in the literature as “molecularly imprinted polymers“, among other names, and hav… Read More
  • Analytical Chemistry

    Wisterone: A Structure I Can’t Believe

    You don’t see an awful lot of chemistry publications from Vietnam. So in a way, I’m reluctant to call attention to this one, in the way that I’m about to. But it’s in the preprint section of Bioorganic and Medicinal Chemistry Letters, and some of my far-flung correspondents have already picked up on it. So… Read More
  • Analytical Chemistry

    Chemical Biology – The Future?

    I agree with many of the commenters around here that one of the most interesting and productive research frontiers in organic chemistry is where it runs into molecular biology. There are so many extraordinary tools that have been left lying around for us by billions of years of evolution; not picking them up and using… Read More
  • Analytical Chemistry

    Running Your Fingers Over A Single Molecule

    Readers will remember the extraordinary pictures of individual pentacene molecules last fall. Well, the same IBM team, working with a group at Aberdeen, has struck again. This time they’ve imaged a much more complex organic molecule, cephalandole A. As that link details, the structure of this natural product has recently been revised –… Read More
  • Analytical Chemistry

    Floyd Landis: The Isotopes Weren’t Lying, After All

    This post from 2006 on the science behind Floyd Landis’s suspicious steroid blood tests set my blog record for comments – the debate went on and on about Landis, about the lab that reported the results, about how the samples were handled, etc. Well, Landis has now admitted using performance-enhancing drugs for most of his… Read More
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