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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Underappreciated Analytical Techniques

    A conversation the other day about 2-D NMR brought this thought to mind. What do you think are the most underused analytical methods in organic chemistry? Maybe I should qualify that, to the most underused (but potentially useful) ones. I know, for example, that hardly anyone takes IR spectra any more. I’ve taken maybe one… Read More
  • Analytical Chemistry

    IBM And The Limits of Transferable Tech Expertise

    Here’s a fine piece from Matthew Herper over at Forbes on an IBM/Roche collaboration in gene sequencing. IBM had an interesting technology platform in the area, which they modestly called the “DNA transistor“. For a while, it was going to the the Next Big Thing in the field (and the material at that last link… Read More
  • Analytical Chemistry

    Mass Spec Continues Its Conquests

    You know, mass spectrometry has been gradually taking over the world. Well, maybe not your world, but mine (and that of a lot of biopharma/biophysical researchers). There are just so many things that you can do with modern instrumentation that the assays and techniques just keep on coming. This paper from a recent Angewandte Chemie… Read More
  • Analytical Chemistry

    X-Ray Structures Of Everything. Without Crystals. Holy Cow.

    There’s an absolutely startling new paper out from Makoto Fujita and co-workers at the University of Tokyo. I’ve written a number of times here about X-ray crystallography, which can be the most powerful tool available for solving the structures of both large and small molecules – if you can get a crystal, and if that… Read More
  • Analytical Chemistry

    Probing A Binding Tunnel With AFM

    Every so often I’ve mentioned some of the work being done with atomic force microscopy (AFM), and how it might apply to medicinal chemistry. It’s been used to confirm a natural product structural assignment, and then there are images like these. Now comes a report of probing a binding site with the technique. The experimental… Read More
  • Analytical Chemistry

    Single-Cell NMR? How About Single-Protein NMR?

    Two different research teams have reported a completely different way to run NMR experiments, one that looks like it could take the resolution down to cellular (or even large protein) levels. These two papers in Science have the details (and there’s an overall commentary here, and more at Nature News). This is not, as you’ve… Read More
  • Analytical Chemistry

    Stanford’s Free Electron Laser Blasts Away

    Here’s another next-generation X-ray crystal paper, this time using a free electron laser X-ray source. That’s powerful enough to cause very fast and significant radiation damage to any crystals you put in its way, so the team used a flow system, with a stream of small crystals of T. brucei cathepsin B enzyme being exposed… Read More
  • Analytical Chemistry

    Every Tiny Detail

    Via Chemjobber, we have here an excellent example of how much detail you have to get into if you’re seriously making a drug for the market. When you have to account for every impurity, and come up with procedures that generate the same ones within the same tight limits every time, this is the sort… Read More
  • Analytical Chemistry

    Picosecond Protein Watching

    We’re getting closer to real-time X-ray structures of protein function, and I think I speak for a lot of chemists and biologists when I say that this has been a longstanding dream. X-ray structures, when they work well, can give you atomic-level structural data, but they’ve been limited to static time scales. In the old… Read More
  • Analytical Chemistry

    GSK’s Anti-Doping Ad

    Courtesy of a reader in the UK, here’s an ad from GlaxoSmithKline that I don’t think has been seen much on this side of the Atlantic. I hadn’t realized that they were involved in the drug testing for the London games; it’s interesting that their public relations folks feel that it’s worth highlighting. They’re al… Read More
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