Skip to Content

Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    GSK’s Anti-Doping Ad

    Courtesy of a reader in the UK, here’s an ad from GlaxoSmithKline that I don’t think has been seen much on this side of the Atlantic. I hadn’t realized that they were involved in the drug testing for the London games; it’s interesting that their public relations folks feel that it’s worth highlighting. They’re al… Read More
  • Analytical Chemistry

    Bungled Structure, And How

    A lot of natural product structures have been misassigned over the years. In the old days, it was a wonder when you were able to assign a complex one at all. Structure determination, pre-NMR, could be an intellectual challenge at the highest level, something like trying to reconstruct a position on a chess board in… Read More
  • Analytical Chemistry

    Fluorine NMR: Why Not?

    Fluorine NMR is underused in chemistry. Well, then again, maybe it’s not, but it’s one of those thing that just seems like it should have more uses than it does. (Here’s a recent bookon the subject). Fluorine is a great NMR nucleus – all the F in the world is the same isotope, unless you’re… Read More
  • Analytical Chemistry

    An NMR Poster

    Here’s a very nice poster-style presentation of proton NMR and spectral interpretation, courtesy of Jon Chui. I wish I’d had something like it when I was learning the topic, and it’s a very useful way to picture it even for those of us who’ve been taking spectra for years. Recommended. Read More
  • Analytical Chemistry

    Proteins in a Living Cell

    It’s messy inside a cell. The closer we look, the more seems to be going on. And now there’s a closer look than ever at the state of proteins inside a common human cell line, and it does nothing but increase your appreciation for the whole process. The authors have run one of these experiments… Read More
  • Analytical Chemistry

    Fishing Around for Biomarkers

    Everyone in this industry wants to have good, predictive biomarkers for human diseases. We’ve wanted that for a very long time, though, and in most cases, we’re still waiting. [For those outside the field, a biomarker is some sort of easy-to-run test that for a factor that correlates with the course of the real disease. Read More
  • Analytical Chemistry

    XMRV: It’s Ugly, But That’s Science

    How’s the XMRV / chronic fatigue syndrome connection holding up? Not real well. Science has a roundup of the latest news in the area, and none of it looks encouraging. There are four studies that have come out in the journal Retrovirology that strongly suggest that earlier positive test results for the virus in CFS… Read More
  • Analytical Chemistry

    Detecting Single Cancer Cells

    This story on a new diagnostic method in oncology is getting a lot of attention in the press. It’s a collaboration between J&J, a small company they’ve bought called Veridex, and several oncology centers to see if very sensitive monitoring of circulating tumor cells could be a more useful biomarker. The press coverage has some… Read More
  • Analytical Chemistry

    NASA’s Arsenic Bacteria: A Call For Follow-Up Experiments

    Since the posts here on the possible arsenic-using bacteria have generated so many comments, I’d like to try to bring things together. If you think that the NASA results need shoring up – and a lot of people do, including me – please leave a comment here about what data or new experiments you’d want… Read More
  • Analytical Chemistry

    Enthalpy and Entropy Again

    Earlier this year, I wrote here about using calorimetry in drug discovery. Years ago, people would have given you the raised eyebrow if you’d suggested that, but it’s gradually becoming more popular, especially among people doing fragment-based drug discovery. After all, the binding energy that we depend on for our drug candidates is a… Read More
...111213...