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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    The Latest Technology

    Well, the latest for 1960, anyway. That’s the Bruker KIS-1 NMR machine there, folks, operating at 25 MHZ, and ready to dim the lights in the whole building when you switch on that electromagnet. Allow about 12 hours of acquisition time to get a decent spectrum. For those of you outside the field, a 300… Read More
  • Analytical Chemistry

    Chemical Biology: Plastic Antibodies?

    Here’s an interesting example of a way that synthetic chemistry is creeping into the provinces of molecular biology. There have been a lot of interesting ideas over the years around the idea of polymers made to recognize other molecules. These appear in the literature as “molecularly imprinted polymers“, among other names, and hav… Read More
  • Analytical Chemistry

    Wisterone: A Structure I Can’t Believe

    You don’t see an awful lot of chemistry publications from Vietnam. So in a way, I’m reluctant to call attention to this one, in the way that I’m about to. But it’s in the preprint section of Bioorganic and Medicinal Chemistry Letters, and some of my far-flung correspondents have already picked up on it. So… Read More
  • Analytical Chemistry

    Chemical Biology – The Future?

    I agree with many of the commenters around here that one of the most interesting and productive research frontiers in organic chemistry is where it runs into molecular biology. There are so many extraordinary tools that have been left lying around for us by billions of years of evolution; not picking them up and using… Read More
  • Analytical Chemistry

    Running Your Fingers Over A Single Molecule

    Readers will remember the extraordinary pictures of individual pentacene molecules last fall. Well, the same IBM team, working with a group at Aberdeen, has struck again. This time they’ve imaged a much more complex organic molecule, cephalandole A. As that link details, the structure of this natural product has recently been revised –… Read More
  • Analytical Chemistry

    Floyd Landis: The Isotopes Weren’t Lying, After All

    This post from 2006 on the science behind Floyd Landis’s suspicious steroid blood tests set my blog record for comments – the debate went on and on about Landis, about the lab that reported the results, about how the samples were handled, etc. Well, Landis has now admitted using performance-enhancing drugs for most of his… Read More
  • Analytical Chemistry

    Masses of Data, In Every Sample

    I’ve said several times that I think that mass spectrometry is taking over the analytical world, and there’s more evidence of that in Angewandte Chemie. A group at Justus Liebig University in Giessen has built what has to be the finest imaging mass spec I’ve ever seen. It’s a MALDI-type machine, which means that a… Read More
  • Analytical Chemistry

    Calorimetry: What Say You?

    I’ve been involved in a mailing list discussion that I wanted to open up to a wider audience in drug discovery, so here goes. We spend our time (well, a lot of it, when we’re not filling out forms) trying to get compound to bind well to our targets. And that binding is, of course… Read More
  • Analytical Chemistry

    Sequenom: Strike Up the Music, Bring On the Cream Pies

    Now here’s a weird one. The San Diego diagnostics company Sequenom came up with a non-invasive test for Down’s Syndrome, and sold it to another outfit, Xenomics, for development. Update: I’ve got this transfer backwards – Xenomics licensed some of its nucleic acid technology to Sequenom, and has now regretted it. But late la… Read More
  • Analytical Chemistry

    The Infinitely Active Impurity

    Yesterday’s post touched on something that all experienced drug discovery people have been through: the compound that works – until a new batch is made. Then it doesn’t work so well. What to do? You have a fork in the road here: one route is labeled “Blame the Assay” and the other one is “Blame… Read More
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