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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Covalent Organic Frameworks

    Let us pause to consider the weirdness of diamond. Not because diamonds are rare – they’re not, at least compared to many other minerals and gemstones. But diamond itself has very unusual physical properties, and that comes down to its structure. As is well known to chemists, it’s a three-dimensional lattice of bonded sp3 carbons… Read More
  • Analytical Chemistry

    The Phosphoproteomic Landscape Speaks – What Did It Say, Again?

    Medicinal chemists are extremely familiar with G-protein coupled receptors (GPCRs), and it’s a safe bet that any pretty much any neurotransmitter (for example) that can be named by the general public is a GPCR ligand, too. Serotonin, dopamine, histamine – all the classics are there, and that’s reflected in the number of marketed d… Read More
  • Analytical Chemistry

    Complex Organics Are Out There – Again

    There’s no way, as a chemist and telescope owner, that I could let this story go by. A new paper reports mass spec data from ice grains that have been sprayed from Saturn’s moon Enceladeus, and let’s just say that there’s a lot of stuff in them. Enceladeus and Europa (a broadly similar moon around… Read More
  • Analytical Chemistry

    Looking Way Down Into the Cells

    Pharmacokinetics – the study of how drugs are taken up, distributed, metabolized, and cleared – is obviously a key part of drug development. Every drug substance gets handled somewhat differently by the human body, and these differences can completely determine whether you’ve got an effective therapy or not. But the tools we have… Read More
  • Analytical Chemistry

    Organometallic Oddities

    Synthetic organic chemists spend a lot of time using organometallic coupling reactions, because they can be such great ways to make carbon-carbon (and carbon-heteroatom) bonds. And that’s the currency of the realm: do you want to build up larger molecules from smaller precursors in a controlled fashion? You’re going to have to make bond… Read More
  • Analytical Chemistry

    Clicked DNA: From Lab Curiosity to Analytical Technique

    I’ve written a few times about an odd sort of unnatural DNA sequence, where some of the nucleotides are connected via “click” triazole units rather than the traditional polyphosphate backbone. I remember wondering what the chemical biology community would make out of these things, and I wanted to report on at least one ingenious a… Read More
  • Analytical Chemistry

    Chiral Separations With Magnets. No, For Real.

    Now here is something I didn’t expect: what may well be a completely new way to separate enantiomers, not based in any way on shape recognition versus another chiral substance. [Quick background for those not in the field: a great many three-dimensional molecules can exist in right-handed and left-handed mirror-image forms (enantiomers), exac… Read More
  • Analytical Chemistry

    A New Method to Weigh Biomolecules

    I’m always happy when a new analytical technique is worked out, especially one that’s applicable to biological binding assays, doesn’t require labeling of the species involved, and is orthogonal to the existing methods. We need all the reality checks we can get, and this one (reported by a large multinational team led out of Oxfor… Read More
  • Analytical Chemistry

    Mirror Proteins Come Through

    You know, chemistry is kind of a big field. I say that because I’ve been actively reading the chemical literature for over thirty years now, and I still keep running across topics that I never knew existed. One of these popped up the other day: racemic protein crystallography. Now there may be a few readers… Read More
  • Analytical Chemistry

    More on Crystal Formation (This Time With Proteins)

    I realize that I was just talking about crystal formation here the other day, but there’s yet more news in the area, and it comes in the fiendishly difficult area of protein crystallography. All you have to do to appreciate the horrors of this field is to step into a lab that does it for… Read More
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