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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Tie Your Crystals Into Knots

    Chemists love crystals. We don’t do as much recrystallization as we used to, since there are higher-throughput (and less labor-intensive) ways of purifying things these days, but I don’t think I’ve ever met an organic chemist who isn’t happy when a product crystallized out nicely. And we all know what crystals are like ̵… Read More
  • Analytical Chemistry

    Nature Doesn’t Abhor a Vacuum As Much As You’d Think

    I wrote some years ago about the case of a protein that seemed to have a completely empty binding pocket – empty, as in not even any water molecules hanging around in there. There are a number of these known, and there’s a lot of arguing about them among both experimental and computational chemists. You’d… Read More
  • Analytical Chemistry

    Rise of the Electron Beams

    There was apparently a very impressive talk from Sriram Subramaniam on cryo-electron microscopy (cryo-EM) at the Computer-Assisted Drug Design Gordon Conference, and I can well believe it. That field has grown tremendously in capabilities in recent years, and is producing some startling results – and those results are coming faster all the t… Read More
  • Analytical Chemistry

    Enantioselectivity With Microwaves

    This new paper is a very interesting approach to chiral separation, and I would like to go into detail about how it works. Unfortunately, section 2 of the Supplementary material goes into detail, and it’s titled “Three-level optical Bloch equations”, and I can just about follow it until I get to the part that says “The… Read More
  • Analytical Chemistry

    A New Factor in Protein Folding

    I linked to this particular XKCD strip when it came out, but it came right back to mind when I saw this paper, on a new kind of intramolecular interaction in proteins (and other systems). Protein folding, macromolecular folding in general, is indeed a famously horrendous problem to attack from first principles. There’s been progress… Read More
  • Analytical Chemistry

    NMR Continues to Bear Down on Structures

    Determining the structure of a new molecule is one of those things that you’d think would be simple – at least, nonscientists often seem surprised at how much of our time we spend on such problems. (It doesn’t help that dramatic depictions involving chemistry almost invariably skip over this problem in the interest of moving the… Read More
  • Analytical Chemistry

    Epigenetics Is Not What You Would Call a Settled Field

    Everyone knows the canonical bases of the nucleic acids. Well, OK, not every single person, but a whole of lot of people do, and I’m willing to bet that if you stopped a bunch of random strangers, you’d get more “A, T, C, G” answers than you might think, thanks to movies and popular culture. Read More
  • Analytical Chemistry

    A Rebirth for IR Spectroscopy?

    As new technologies develop, they can end up bringing back some old ones. That might be the case for infrared spectroscopy. Most organic chemists use it infrequently – in my case, years go by between taking an IR spectrum. There are infrared sensors that can go right into a reaction mixture (or flow stream), and… Read More
  • Analytical Chemistry

    Triangulene, By Force

    The molecule on the right is triangulene, and it’s an odd one. You’d think at first that you could fill everything in with alternating double bonds, like a small piece of graphite or a bigger relative of anthracene, but when you try, you find that the geometry won’t let you. You’re either going to end… Read More
  • Analytical Chemistry

    All The Way Down to the Hydrogens

    I’m always happy to see new techniques for resolving structures of molecules (large and small) and figuring out their behavior. Even if the latest instrument or method doesn’t seem to have any bearing on what I’m doing, or even on drug research in general, it could end up helping. It’s Sydney Brenner‘s 90th birthday to… Read More
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