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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Going After Ebola

    How small-molecule drugs fit into binding pockets in their targets is one of the central questions of medicinal chemistry. A new paper from a group at Oxford gives a good example of how varied that process can be – it’s looking at a number of drugs that have been shown to interfere (to some degree) with… Read More
  • Analytical Chemistry

    How a Compound Dissolves – One Water Molecule At a Time

    Here’s another one of those nanoscale articles that gives me a bit of a shiver, because it shows pictures of something that I had assumed was beyond our ability to see. The authors, from the Ruhr University in Bochum, are looking at a simple organic molecule (an azobenzene, shown at right), adsorbed onto a solid… Read More
  • Analytical Chemistry

    Two Molecules, When You Were Expecting Just One

    Here’s a good short review on a subject that doesn’t come up too often in drug discovery, but can be a major headache when it does: atropisomerism. There are all sorts of structural isomers possible for organic compounds, and students in their second-year class have a joyful time learning them and keeping them straight. But… Read More
  • Analytical Chemistry

    Stereochemical Mysteries, Solved

    Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it does that, and in 99 cases out of a hundred, you’ll witness… Read More
  • Analytical Chemistry

    A Rain of Tiny Droplets

    You might be surprised to know how little we chemists know about what our reactions are really doing. A case in point is the “on water” field. Water is generally not the greatest solvent for a lot of classic organic chemistry reactions, since the reactants, reagents, and products are often not very soluble (or are… Read More
  • Analytical Chemistry

    A Nobel for Cryo-EM

    The Chemistry Nobel committee seems to have taken everyone by surprise today with their award for cryo-electron microscopy (cryo-EM). That’s not because it isn’t Nobel-worthy, though – it certainly is. But they tend to take their time before recognizing discoveries (ask 95-year-old John Goodenough, a key inventor of the lithium ba… Read More
  • Analytical Chemistry

    Short Chemistry Topics

    Blogging time is tight today, but there are several interesting stories and follow-ups that I wanted to mention. For starters, I wrote here about a cyclohexane analog that’s fluorinated all on one side of the molecule. That gives you very odd properties, and it and its relatives could be really useful solvents and additives, but… Read More
  • Analytical Chemistry

    Tie Your Crystals Into Knots

    Chemists love crystals. We don’t do as much recrystallization as we used to, since there are higher-throughput (and less labor-intensive) ways of purifying things these days, but I don’t think I’ve ever met an organic chemist who isn’t happy when a product crystallized out nicely. And we all know what crystals are like ̵… Read More
  • Analytical Chemistry

    Nature Doesn’t Abhor a Vacuum As Much As You’d Think

    I wrote some years ago about the case of a protein that seemed to have a completely empty binding pocket – empty, as in not even any water molecules hanging around in there. There are a number of these known, and there’s a lot of arguing about them among both experimental and computational chemists. You’d… Read More
  • Analytical Chemistry

    Rise of the Electron Beams

    There was apparently a very impressive talk from Sriram Subramaniam on cryo-electron microscopy (cryo-EM) at the Computer-Assisted Drug Design Gordon Conference, and I can well believe it. That field has grown tremendously in capabilities in recent years, and is producing some startling results – and those results are coming faster all the t… Read More
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