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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Not So Fast on the PD-L1 Comparisons

    We may have to rethink what we think about the recent trial in which Bristol-Myers Squibb’s Opdivo was ineffective in non-small cell lung cancer. The arguing has been about the status of the patients, specifically how much PD-L1 protein they were expressing. But writing in BioCentury, Stephen Hansen points out that comparing the various trial… Read More
  • Analytical Chemistry

    Theranos and the Limits of Salesmanship

    I haven’t been covering every step of the Great Theranos Unraveling, partly because it’s been on every news site there is. But the company (in the person of Elizabeth Holmes) recently disclosed yet another new blood testing device, in a presentation at the American Association for Clinical Chemistry meeting. That might seem an audaciou… Read More
  • "Me Too" Drugs

    Isotope Labeling For Fun and Profit

    Here’s an article on a company called Molecular Isotope Technologies, and their bid to “revolutionize the drug industry”. From the name, you might expect that this is another deuterium-for-proton idea, and you would say to yourself “But that’s already been done”. But read on. The company is perhaps better known b… Read More
  • Analytical Chemistry

    Not So Verily

    The folks at Stat clearly have some good sources inside Google’s Verily startup. They ran a story back in March about problems with the CEO (blogged about here), and now they’re back with more opinion from within. This piece has a number of people expressing dissatisfaction with how Verily’s three big projects are actually going… Read More
  • Analytical Chemistry

    Single Molecules, Single Atoms, and More

    I wrote in 2013 about work that opens the possibility of single-cell (or single-molecule) NMR and other techniques, using nitrogen-vacancy (NV) diamond surfaces. I’m glad to report that there’s enough going on in this field to be the subject of a minireview in Angewandte Chemie. You make these things by synthesizing diamond particles wi… Read More
  • Analytical Chemistry

    Another Crashing Noise From the Basement

    In case you’ve missed, it, Theranos (the blood-testing company whose secretive technology has been taking some major blows over the last few months) has reached yet another unwelcome stage in its troubles. First you have people expressing doubts about the company’s product, then you have worries about their customers defecting, then you… Read More
  • Analytical Chemistry

    Grinding Up The Leaves and Roots

    I’ve been meaning to write about this Stat profile of Jing-ke Weng at the Whitehead Institute, who’s searching for medicinally active compounds in exotic plants. That’s a field with a long and honorable history – some ferociously active compounds come from plant sources, and some terrific drugs have, too. But it’s been… Read More
  • Analytical Chemistry

    One Fragment to Bind Them All

    A colleague put me onto this paper, which appears in a journal (IUCrJ) that it’s safe to say that I don’t keep up with very closely. The authors, from Rutgers, are looking at fragment screening, and have found that 4-bromopyrazole and 4-iodopyrazole are very odd in that regard. They show up as hits in fragment… Read More
  • Analytical Chemistry

    The X-Ray Future, And Others

    It’s been up for a while, but I found this essay on the future of X-ray crystallography at Chemical and Engineering News to be interesting. It was part of their “100 years of crystallography” section from August 2014, and those sort of have to end with a “Where do we go from here?” piece. Even… Read More
  • Analytical Chemistry

    Getting Personal With the Bergman Cyclization

    I enjoyed seeing this article in Nature Chemistry, where a Bergman cyclization is made to run (forwards and backwards) by pushing the molecules around with an atomic force microscope. It’s still startling to see this sort of thing in action, and I imagine that few find it stranger than Robert Bergman himself, who will be… Read More
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