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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    A New Factor in Protein Folding

    I linked to this particular XKCD strip when it came out, but it came right back to mind when I saw this paper, on a new kind of intramolecular interaction in proteins (and other systems). Protein folding, macromolecular folding in general, is indeed a famously horrendous problem to attack from first principles. There’s been progress… Read More
  • Analytical Chemistry

    NMR Continues to Bear Down on Structures

    Determining the structure of a new molecule is one of those things that you’d think would be simple – at least, nonscientists often seem surprised at how much of our time we spend on such problems. (It doesn’t help that dramatic depictions involving chemistry almost invariably skip over this problem in the interest of moving the… Read More
  • Analytical Chemistry

    Epigenetics Is Not What You Would Call a Settled Field

    Everyone knows the canonical bases of the nucleic acids. Well, OK, not every single person, but a whole of lot of people do, and I’m willing to bet that if you stopped a bunch of random strangers, you’d get more “A, T, C, G” answers than you might think, thanks to movies and popular culture. Read More
  • Analytical Chemistry

    A Rebirth for IR Spectroscopy?

    As new technologies develop, they can end up bringing back some old ones. That might be the case for infrared spectroscopy. Most organic chemists use it infrequently – in my case, years go by between taking an IR spectrum. There are infrared sensors that can go right into a reaction mixture (or flow stream), and… Read More
  • Analytical Chemistry

    Triangulene, By Force

    The molecule on the right is triangulene, and it’s an odd one. You’d think at first that you could fill everything in with alternating double bonds, like a small piece of graphite or a bigger relative of anthracene, but when you try, you find that the geometry won’t let you. You’re either going to end… Read More
  • Analytical Chemistry

    All The Way Down to the Hydrogens

    I’m always happy to see new techniques for resolving structures of molecules (large and small) and figuring out their behavior. Even if the latest instrument or method doesn’t seem to have any bearing on what I’m doing, or even on drug research in general, it could end up helping. It’s Sydney Brenner‘s 90th birthday to… Read More
  • Aging and Lifespan

    Isotopes, Get Your Revivifying Isotopes

    Here’s your chance to get in on the ground floor – at least, the ground floor of a pitch you probably haven’t heard before. The chemists and biologists in the crowd will be familiar with how isotopic enrichment takes place in biological systems. Bonds between heavier atoms are slightly harder to break, making the rate constants… Read More
  • Analytical Chemistry

    Right Hand, Left Hand, Either Hand

    Medicinal chemists like it when one enantiomer of a compound binds to a target much more than the other one. That tells you that you’re getting real binding to a protein target, and the bigger the difference between the two, the more you can say about the actual binding site. But is this always true?… Read More
  • Analytical Chemistry

    Not So Fast on the PD-L1 Comparisons

    We may have to rethink what we think about the recent trial in which Bristol-Myers Squibb’s Opdivo was ineffective in non-small cell lung cancer. The arguing has been about the status of the patients, specifically how much PD-L1 protein they were expressing. But writing in BioCentury, Stephen Hansen points out that comparing the various trial… Read More
  • Analytical Chemistry

    Theranos and the Limits of Salesmanship

    I haven’t been covering every step of the Great Theranos Unraveling, partly because it’s been on every news site there is. But the company (in the person of Elizabeth Holmes) recently disclosed yet another new blood testing device, in a presentation at the American Association for Clinical Chemistry meeting. That might seem an audaciou… Read More