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  • Picky, Picky NMR Magnets

    Unless you’ve had to take care of an NMR facility, you might not have realized how many large chunks of ferromagnetic material might be moving around clos… Read More
  • Cryo-EM On the March

    Cryo-electron microscopy has been scoring some real successes lately as a structural biology technique. Anything that provides protein structures without having… Read More
  • The Tramadol Wars

    You may recall the report of the synthetic analgesic tramadol as a natural product from Cameroon, and the subsequent report that it was nothing of the kind. (Th… Read More
  • Tiny (And Not So Tiny) Changes

    A huge amount of medicinal chemistry – and a huge amount of medicine – depends on small molecules binding to protein targets. Despite decades of stu… Read More
  • X-Ray Sponges Ride Again

    The Fujita group has a new paper out on their “crystalline sponge” method for X-ray structure determination. I had the chance to hear Prof. Fujita s… Read More
  • Fun With Thermodynamics

    Here’s a very good review in J. Med. Chem. on thermodynamics and drug discovery. That topic has come up at this site several times over the years, and I&# Read More
  • Better Drinking Through Chemistry

    This is a fascinating article about a guy who’s looking into the chemistry of aged spirits – rum, whiskey, cognac, and so on – and trying to f… Read More
  • Herbal Disclosure

    Rather quickly, we have some results from that conflict between the New York State Attorney General and the herbal supplements retailers. GNC has reached a deal… Read More
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