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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Another Crashing Noise From the Basement

    In case you’ve missed, it, Theranos (the blood-testing company whose secretive technology has been taking some major blows over the last few months) has reached yet another unwelcome stage in its troubles. First you have people expressing doubts about the company’s product, then you have worries about their customers defecting, then you… Read More
  • Analytical Chemistry

    Grinding Up The Leaves and Roots

    I’ve been meaning to write about this Stat profile of Jing-ke Weng at the Whitehead Institute, who’s searching for medicinally active compounds in exotic plants. That’s a field with a long and honorable history – some ferociously active compounds come from plant sources, and some terrific drugs have, too. But it’s been… Read More
  • Analytical Chemistry

    One Fragment to Bind Them All

    A colleague put me onto this paper, which appears in a journal (IUCrJ) that it’s safe to say that I don’t keep up with very closely. The authors, from Rutgers, are looking at fragment screening, and have found that 4-bromopyrazole and 4-iodopyrazole are very odd in that regard. They show up as hits in fragment… Read More
  • Analytical Chemistry

    The X-Ray Future, And Others

    It’s been up for a while, but I found this essay on the future of X-ray crystallography at Chemical and Engineering News to be interesting. It was part of their “100 years of crystallography” section from August 2014, and those sort of have to end with a “Where do we go from here?” piece. Even… Read More
  • Analytical Chemistry

    Getting Personal With the Bergman Cyclization

    I enjoyed seeing this article in Nature Chemistry, where a Bergman cyclization is made to run (forwards and backwards) by pushing the molecules around with an atomic force microscope. It’s still startling to see this sort of thing in action, and I imagine that few find it stranger than Robert Bergman himself, who will be… Read More
  • Analytical Chemistry

    So What Exactly is SCR7?

    Those of you who are into CRISPR will likely have heard for SCR7. It’s a compound added to the system that seems to enhance its efficiency and specificity, presumably through its inhibition of DNA ligase IV. That’s all fine – the mechanism makes sense, and making CRISPR more selective is a worthy goal that any… Read More
  • Analytical Chemistry

    The Case For Non-Biogenic Tramadol

    The battle over whether tramadol is a natural product or not has been a heated one. Over the last couple of years, it was reported to be produced by a west African shrub, then this was reported to be an artifact of feeding the drug to cattle, and then this hypothesis was challenged by work… Read More
  • Analytical Chemistry

    Theranos And Its Blood Test Machine

    Theranos is a very high-profile startup doing blood tests. You’ve probably come across them (or their founder, Elizabeth Holmes), promoting “X number of tests from a single drop of blood” and so on. The company has been making a big splash since at least 2013, when this article in the Wall Street Journal came out (I keep… Read More
  • Analytical Chemistry

    Immunology, Under the Hood

    Here’s an example of the move to nanoscale that I was writing about the other day, but from the other end of the stick. As chemists have been moving up from small molecules to dealing with larger structures, biologists have been moving down from whole-cell studies to more detailed pictures of what’s happening locally. The… Read More
  • Analytical Chemistry

    Invisible Crystals Yield Structure

    A crystallographer colleague passes on this new paper, which I find very interesting and just a bit freaky. The authors (a collaboration between UCLA, HHMI, LBNL, and SLAC) are studying alpha-synuclein, the protein that aggregates in Parkinson’s disease pathology, and more particularly, they’re studying a short (11-amino acid) section o… Read More
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