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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Spectra of An Actual Transition State?

    I don’t spend too much time on physical organic chemistry here on the blog, which in a way is a shame. The readership would dwindle, although probably not as much as when I talk about patent law and intellectual property. But physical organic is an area I’ve always enjoyed, intellectually, even though it was sometimes… Read More
  • Analytical Chemistry

    More Herbal Goodness

    As many will have heard, the New York State Attorney General’s office is going after a number of herbal supplement retailers for selling products with poor quality controls. A range of supplements (including echinacea, garlic, gingko, and saw palmetto) were purchased, and analyzed by the “DNA barcode” technique at Clarkson U. The… Read More
  • Analytical Chemistry

    Guidelines For MOF Crystallography

    There’s a new and very useful paper out on the “molecular sponge” technique for crystallography (first blogged about here, with updates here and here). It’s from the Clardy group at Harvard with collaboration from Argonne, in Acta Crystallographica, and you can tell by reading it that it’s intended to put the whole met… Read More
  • Analytical Chemistry

    NMR of a Mass Spec Species

    I have to say, I didn’t even know that this could be done. This paper from Angewandte Chemie describes a mass spec/NMR combination analysis that had never occurred to me as possible. The authors (from Ohio U. and Purdue) are looking at a common peptide ion seen in proteomic mass spec studies. And what they… Read More
  • Analytical Chemistry

    Google’s Nanoparticle Diagnostic Ideas

    Google’s “Google X” division, the part that works on odd high-risk high-reward projects, is apparently interested in diagnostic nanoparticles. That Wired article is pretty short on specifics, but the company’s Andrew Conrad revealed a few details in a talk yesterday. The idea, apparently, is to use magnetic-cored nanoparticl… Read More
  • Analytical Chemistry

    Phenylalanine Crystals

    No matter how long you’ve been doing chemistry, there are still things that you come across that surprise you. Did you know that plain old L-phenylalanine has been one of the most difficult subjects ever for small-molecule crystallography? I sure didn’t. But people have tried for decades to grow good enough crystals of it to… Read More
  • Analytical Chemistry

    No More Varian

    This week has brought news that Agilent is getting out of the NMR business, which brings an end to the Varian line of machines, one of the oldest in the business. (Agilent bought Varian in 2010). The first NMR I ever used was a Varian EM-360, which was the workhorse teaching instrument back then. A… Read More
  • Analytical Chemistry

    Seaborgium hexacarbonyl

    If you want to really push the frontiers of analytical chemistry, try making compounds of the superheavy elements. Science is reporting the characterization of seaborgium hexacarbonyl, which gives us all a chance to use Sg in an empirical formula. We’re not going to be using it too often, though, because this work was conducted on… Read More
  • Analytical Chemistry

    Weirdly, Tramadol Is Not a Natural Product After All

    Last year I mentioned a paper that described the well-known drug tramadol as a natural product, isolated from a species of tree in Cameroon. Rather high concentrations were found in the root bark, and the evidence looked solid that the compound was indeed being made biochemically. Well, thanks to chem-blogger Quintus (and a mention on… Read More
  • Analytical Chemistry

    Fluorinated Fingerprinting

    How many ways do we have to differentiate samples of closely related compounds? There’s NMR, of course, and mass spec. But what if two compounds have the same mass, or have unrevealing NMR spectra? Here’s a new paper in JACS that proposes another method entirely. Well, maybe not entirely, because it still relies on NMR. Read More
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