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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Tiny (And Not So Tiny) Changes

    A huge amount of medicinal chemistry – and a huge amount of medicine – depends on small molecules binding to protein targets. Despite decades of study, though, with all the technology we can bring to bear on the topic, we still don’t have as clear a picture of the process as we’d like. Protein structure… Read More
  • Analytical Chemistry

    X-Ray Sponges Ride Again

    The Fujita group has a new paper out on their “crystalline sponge” method for X-ray structure determination. I had the chance to hear Prof. Fujita speak on this recently – a very interesting talk indeed – and I’ve been looking forward to the paper. (Here’s a summary from an equally impressed Quintus). This time,… Read More
  • Analytical Chemistry

    Quenching NMRs, Accidentally and On Purpose

    You may remember the MRI accident in India, where someone brought an oxygen tank into the imaging room. The consequence were not good ones – not only did two people get pinned to the machine by said tank, it took hours for them to kill the magnet because the emergency quench circuit was deactivated. A… Read More
  • Analytical Chemistry

    Fun With Thermodynamics

    Here’s a very good review in J. Med. Chem. on thermodynamics and drug discovery. That topic has come up at this site several times over the years, and I’ve been wondering if anyone’s reached a consensus yet. What I take away from this new article is “Nope. Not yet.” Update: see also this review, also… Read More
  • Analytical Chemistry

    Protein Structures Without Crystallization

    Here’s a report from a team at the University of Toronto of a new way to get protein structures – always a welcome development. (There a summary at Technology Review here). It’s another application of electron cryomicroscopy, which was the subject of a blog post here about a year and half back. As with many… Read More
  • Analytical Chemistry

    Better Drinking Through Chemistry

    This is a fascinating article about a guy who’s looking into the chemistry of aged spirits – rum, whiskey, cognac, and so on – and trying to find ways, as he puts it, to hack the process. I’m not a drinker myself, but I’ve watched with interest as the craft spirits movement has become popular. Read More
  • Analytical Chemistry

    Herbal Disclosure

    Rather quickly, we have some results from that conflict between the New York State Attorney General and the herbal supplements retailers. GNC has reached a deal with the office, and will (1) use DNA barcoding assays to verify that their plant-material supplements are actually the plant on the label, (2) state in its stores and… Read More
  • Analytical Chemistry

    Spectra of An Actual Transition State?

    I don’t spend too much time on physical organic chemistry here on the blog, which in a way is a shame. The readership would dwindle, although probably not as much as when I talk about patent law and intellectual property. But physical organic is an area I’ve always enjoyed, intellectually, even though it was sometimes… Read More
  • Analytical Chemistry

    More Herbal Goodness

    As many will have heard, the New York State Attorney General’s office is going after a number of herbal supplement retailers for selling products with poor quality controls. A range of supplements (including echinacea, garlic, gingko, and saw palmetto) were purchased, and analyzed by the “DNA barcode” technique at Clarkson U. The… Read More
  • Analytical Chemistry

    Guidelines For MOF Crystallography

    There’s a new and very useful paper out on the “molecular sponge” technique for crystallography (first blogged about here, with updates here and here). It’s from the Clardy group at Harvard with collaboration from Argonne, in Acta Crystallographica, and you can tell by reading it that it’s intended to put the whole met… Read More
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