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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Google’s Nanoparticle Diagnostic Ideas

    Google’s “Google X” division, the part that works on odd high-risk high-reward projects, is apparently interested in diagnostic nanoparticles. That Wired article is pretty short on specifics, but the company’s Andrew Conrad revealed a few details in a talk yesterday. The idea, apparently, is to use magnetic-cored nanoparticl… Read More
  • Analytical Chemistry

    Phenylalanine Crystals

    No matter how long you’ve been doing chemistry, there are still things that you come across that surprise you. Did you know that plain old L-phenylalanine has been one of the most difficult subjects ever for small-molecule crystallography? I sure didn’t. But people have tried for decades to grow good enough crystals of it to… Read More
  • Analytical Chemistry

    No More Varian

    This week has brought news that Agilent is getting out of the NMR business, which brings an end to the Varian line of machines, one of the oldest in the business. (Agilent bought Varian in 2010). The first NMR I ever used was a Varian EM-360, which was the workhorse teaching instrument back then. A… Read More
  • Analytical Chemistry

    Seaborgium hexacarbonyl

    If you want to really push the frontiers of analytical chemistry, try making compounds of the superheavy elements. Science is reporting the characterization of seaborgium hexacarbonyl, which gives us all a chance to use Sg in an empirical formula. We’re not going to be using it too often, though, because this work was conducted on… Read More
  • Analytical Chemistry

    Weirdly, Tramadol Is Not a Natural Product After All

    Last year I mentioned a paper that described the well-known drug tramadol as a natural product, isolated from a species of tree in Cameroon. Rather high concentrations were found in the root bark, and the evidence looked solid that the compound was indeed being made biochemically. Well, thanks to chem-blogger Quintus (and a mention on… Read More
  • Analytical Chemistry

    Fluorinated Fingerprinting

    How many ways do we have to differentiate samples of closely related compounds? There’s NMR, of course, and mass spec. But what if two compounds have the same mass, or have unrevealing NMR spectra? Here’s a new paper in JACS that proposes another method entirely. Well, maybe not entirely, because it still relies on NMR. Read More
  • Analytical Chemistry

    Thalidomide, Bound to Its Target

    There’s a new report in the literature on the mechanism of thalidomide, so I thought I’d spend some time talking about the compound. Just mentioning the name to anyone familiar with its history is enough to bring on a shiver. The compound, administered as a sedative/morning sickness remedy to pregnant women in the 1950s and… Read More
  • Alzheimer's Disease

    An Alzheimer’s Blood Test? Not So Fast.

    There all all sorts of headlines today about how there’s going to be a simple blood test for Alzheimer’s soon. Don’t believe them. This all comes from a recent publication in the journal Alzheimer’s and Dementia, from a team at King’s College (London) and the company Proteome Sciences. It’s a perfectly good paper… Read More
  • Analytical Chemistry

    Catalyst Voodoo, Yielding to Spectroscopy?

    Catalysts are absolutely vital to almost every field of chemistry. And catalysis, way too often, is voodoo or a close approximation thereof. A lot of progress has been made over the years, and in some systems we have a fairly good idea of what the important factors are. But even in the comparatively well-worked-out areas… Read More
  • Analytical Chemistry

    A Horrible, Expensive, and Completely Avoidable Drug Development Mixup

    C&E News has a story today that is every medicinal chemist’s nightmare. We are paid to find and characterize chemical matter, and to develop it (by modifying structures and synthesizing analogs) into something that can be a drug. Key to that whole process is knowing what structure you have in the first place, and now… Read More
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