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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Seaborgium hexacarbonyl

    If you want to really push the frontiers of analytical chemistry, try making compounds of the superheavy elements. Science is reporting the characterization of seaborgium hexacarbonyl, which gives us all a chance to use Sg in an empirical formula. We’re not going to be using it too often, though, because this work was conducted on… Read More
  • Analytical Chemistry

    Weirdly, Tramadol Is Not a Natural Product After All

    Last year I mentioned a paper that described the well-known drug tramadol as a natural product, isolated from a species of tree in Cameroon. Rather high concentrations were found in the root bark, and the evidence looked solid that the compound was indeed being made biochemically. Well, thanks to chem-blogger Quintus (and a mention on… Read More
  • Analytical Chemistry

    Fluorinated Fingerprinting

    How many ways do we have to differentiate samples of closely related compounds? There’s NMR, of course, and mass spec. But what if two compounds have the same mass, or have unrevealing NMR spectra? Here’s a new paper in JACS that proposes another method entirely. Well, maybe not entirely, because it still relies on NMR. Read More
  • Analytical Chemistry

    Thalidomide, Bound to Its Target

    There’s a new report in the literature on the mechanism of thalidomide, so I thought I’d spend some time talking about the compound. Just mentioning the name to anyone familiar with its history is enough to bring on a shiver. The compound, administered as a sedative/morning sickness remedy to pregnant women in the 1950s and… Read More
  • Alzheimer's Disease

    An Alzheimer’s Blood Test? Not So Fast.

    There all all sorts of headlines today about how there’s going to be a simple blood test for Alzheimer’s soon. Don’t believe them. This all comes from a recent publication in the journal Alzheimer’s and Dementia, from a team at King’s College (London) and the company Proteome Sciences. It’s a perfectly good paper… Read More
  • Analytical Chemistry

    Catalyst Voodoo, Yielding to Spectroscopy?

    Catalysts are absolutely vital to almost every field of chemistry. And catalysis, way too often, is voodoo or a close approximation thereof. A lot of progress has been made over the years, and in some systems we have a fairly good idea of what the important factors are. But even in the comparatively well-worked-out areas… Read More
  • Analytical Chemistry

    A Horrible, Expensive, and Completely Avoidable Drug Development Mixup

    C&E News has a story today that is every medicinal chemist’s nightmare. We are paid to find and characterize chemical matter, and to develop it (by modifying structures and synthesizing analogs) into something that can be a drug. Key to that whole process is knowing what structure you have in the first place, and now… Read More
  • Analytical Chemistry

    Xenon’s Use as a Sports Drug Is Banned

    Just a couple of months ago, I wrote about how xenon has been used as a performance-enhancing drug. Well, now it’s banned. But I’d guess that they’re going to have to look for its downstream effects, because detecting xenon itself, particularly a good while after exposure, is going to be a tall order. . . Read More
  • Analytical Chemistry

    A New NMR Probe Technology in the Making?

    This paper is outside of my usual reading range, but when I saw the title, the first thing that struck me was “NMR probes”. The authors describe a very sensitive way to convert weak radio/microwave signals to an optical readout, with very low noise. And looking over the paper, that’s one of the applications they… Read More
  • Analytical Chemistry

    A New Way to Get Protein Crystal Structures

    There’s a report of a new technique to solve protein crystal structures on a much smaller scale than anyone’s done before. Here’s the paper: the team at the Howard Hughes Medical Institute has used cryo-electron microscopy to do electron diffraction on microcrystals of lysozyme protein. We present a method, ‘MicroED’, for stru… Read More