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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Xenon’s Use as a Sports Drug Is Banned

    Just a couple of months ago, I wrote about how xenon has been used as a performance-enhancing drug. Well, now it’s banned. But I’d guess that they’re going to have to look for its downstream effects, because detecting xenon itself, particularly a good while after exposure, is going to be a tall order. . . Read More
  • Analytical Chemistry

    A New NMR Probe Technology in the Making?

    This paper is outside of my usual reading range, but when I saw the title, the first thing that struck me was “NMR probes”. The authors describe a very sensitive way to convert weak radio/microwave signals to an optical readout, with very low noise. And looking over the paper, that’s one of the applications they… Read More
  • Analytical Chemistry

    A New Way to Get Protein Crystal Structures

    There’s a report of a new technique to solve protein crystal structures on a much smaller scale than anyone’s done before. Here’s the paper: the team at the Howard Hughes Medical Institute has used cryo-electron microscopy to do electron diffraction on microcrystals of lysozyme protein. We present a method, ‘MicroED’, for stru… Read More
  • Analytical Chemistry

    Crystallography Without Crystallizing: An Update

    I wrote here about a very promising X-ray crystallography technique which produces structures of molecules that don’t even have to be crystalline. Soaking a test substance into a metal-organic-framework (MOF) lattice gave enough repeating order that x-ray diffraction was possible. The most startling part of the paper, other than the concept i… Read More
  • Analytical Chemistry

    Ligands From Nothing

    Well, nearly nothing. That’s the promise of a technique that’s been published by the Ernst lab from the University of Basel. They first wrote about this in 2010, in a paper looking for ligands to the myelin-associated glycoprotein (MAG). That doesn’t sound much like a traditional drug target, and so it isn’t. It’s part… Read More
  • Analytical Chemistry

    An HIV Structure Breakthrough? Or “Complete Rubbish”?

    Structural biology needs no introduction for people doing drug discovery. This wasn’t always so. Drugs were discovered back in the days when people used to argue about whether those “receptor” thingies were real objects (as opposed to useful conceptual shorthand), and before anyone had any idea of what an enzyme’s active sit… Read More
  • Analytical Chemistry

    The 3D Fragment Consortium

    Fragment-based screening comes up here fairly often (and if you’re interested in the field, you should also have Practical Fragments on your reading list). One of the complaints both inside and outside the fragment world is that there are a lot of primary hits that fall into flat/aromatic chemical space (I know that those two… Read More
  • Analytical Chemistry

    New Frontiers in Analytical Chemistry

    A reader sends this new literature citation along, from Organometallics. He directed my attention to the Supplementary Information file, page 12. And what do we find there? . . .Solvent was then removed to leave a yellow residue in the vial, the remaining clear, yellow solution was concentrated to a volume of about 1ml, and… Read More
  • Analytical Chemistry

    Touching Up the Spectra

    Organic chemists have been taking NMR spectra for quite a while now. Routine use came on in the 1960s, and higher-field instruments went from exotic big-ticket items in the 1970s to ordinary equipment in the 1980s. But NMR can tell you more about your sample than you wanted to know (good analytical techniques are annoying… Read More
  • Analytical Chemistry

    Picking Out Incorrect Natural Products

    Once in a while, you see people who’ve gone to the trouble of synthesizing a natural product, only to find that its structure had been incorrectly assigned. (Back in the days when structure elucidation was much harder, R. B. Woodward had this on his list of reasons to do total synthesis, although it wasn’t number… Read More
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