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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Touching Up the Spectra

    Organic chemists have been taking NMR spectra for quite a while now. Routine use came on in the 1960s, and higher-field instruments went from exotic big-ticket items in the 1970s to ordinary equipment in the 1980s. But NMR can tell you more about your sample than you wanted to know (good analytical techniques are annoying… Read More
  • Analytical Chemistry

    Picking Out Incorrect Natural Products

    Once in a while, you see people who’ve gone to the trouble of synthesizing a natural product, only to find that its structure had been incorrectly assigned. (Back in the days when structure elucidation was much harder, R. B. Woodward had this on his list of reasons to do total synthesis, although it wasn’t number… Read More
  • Analytical Chemistry

    GPCRs Are As Crazy As You Thought

    That’s my take-away from this paper, which takes a deep look at a reconstituted beta-adrenergic receptor via fluorine NMR. There are at least four distinct states (two inactive ones, the active one, and an intermediate), and the relationships between them are different with every type of ligand that comes in. Even the ones that look… Read More
  • Analytical Chemistry

    Watching DNA Polymerase Do Its Thing

    Single-molecule techniques are really the way to go if you’re trying to understand many types of biomolecules. But they’re really difficult to realize in practice (a complaint that should be kept in context, given that many of these experiments would have sounded like science fiction not all that long ago). Here’s an example of ju… Read More
  • Analytical Chemistry

    Check Out These Molecules

    It’s molecular imaging week! See Arr Oh and others have sent along this paper from Science, a really wonderful example of atomic-level work. (For those without journal access, Wired and PhysOrg have good summaries). As that image shows, what this team has done is take a starting (poly) phenylacetylene compound and let it cyclize to… Read More
  • Analytical Chemistry

    Underappreciated Analytical Techniques

    A conversation the other day about 2-D NMR brought this thought to mind. What do you think are the most underused analytical methods in organic chemistry? Maybe I should qualify that, to the most underused (but potentially useful) ones. I know, for example, that hardly anyone takes IR spectra any more. I’ve taken maybe one… Read More
  • Analytical Chemistry

    IBM And The Limits of Transferable Tech Expertise

    Here’s a fine piece from Matthew Herper over at Forbes on an IBM/Roche collaboration in gene sequencing. IBM had an interesting technology platform in the area, which they modestly called the “DNA transistor“. For a while, it was going to the the Next Big Thing in the field (and the material at that last link… Read More
  • Analytical Chemistry

    Mass Spec Continues Its Conquests

    You know, mass spectrometry has been gradually taking over the world. Well, maybe not your world, but mine (and that of a lot of biopharma/biophysical researchers). There are just so many things that you can do with modern instrumentation that the assays and techniques just keep on coming. This paper from a recent Angewandte Chemie… Read More
  • Analytical Chemistry

    X-Ray Structures Of Everything. Without Crystals. Holy Cow.

    There’s an absolutely startling new paper out from Makoto Fujita and co-workers at the University of Tokyo. I’ve written a number of times here about X-ray crystallography, which can be the most powerful tool available for solving the structures of both large and small molecules – if you can get a crystal, and if that… Read More
  • Analytical Chemistry

    Probing A Binding Tunnel With AFM

    Every so often I’ve mentioned some of the work being done with atomic force microscopy (AFM), and how it might apply to medicinal chemistry. It’s been used to confirm a natural product structural assignment, and then there are images like these. Now comes a report of probing a binding site with the technique. The experimental… Read More
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