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Posts tagged with "Animal Testing"

  • Animal Testing

    Melanocortin: It’s Not Just For Lizards Any More

    If you’re looking for a good example of evolution-as-a-tinkerer, the melanocortin receptors would be a good place to start. From a single starting point, they’ve ended up as a family of related proteins that do completely different things. And the hormones that bind to them have radiated out as well: they’re all derived by process… Read More
  • Alzheimer's Disease

    Just How Worthless Are the Standard Alzheimer’s Models?

    As mentioned yesterday, Alzheimer’s therapies have, for the most part, been a cliff over which people push bales of money. There are plenty of good reasons for this: we don’t really know what the cause of Alzheimer’s is, when you get down to it, and we’re the only animal that we know of that gets… Read More
  • Animal Testing

    Trouble at Santa Cruz Biotechnology

    The commercial antibody market is already a mess, although that’s not a new development, but it’s gotten messier. Santa Cruz Biotech, one of the big suppliers, is getting out of a big part of the business. Actually, “being forced out of the business through their own actions” is probably a better description. The company has… Read More
  • Animal Testing

    A New Chemotherapy Idea

    This is a study whose immediate applications are in the clinic, but it could have follow-on effects in drug discovery and development as well. Writing in Science Translational Medicine, a team from the Moffitt Cancer Center and USF (with analytical help from Bruker) have been trying a new approach in mouse models of cancer. The… Read More
  • Animal Testing

    A Terrific Paper on the Problems in Drug Discovery

    Here’s a really interesting paper from consultants Jack Scannell and Jim Bosley in PLoS ONE, on the productivity crisis in drug discovery. Several things distinguish it: for one, it’s not just another “whither the drug industry” think piece, of which we have plenty already. This one get quantitative, attempting to figure out… Read More
  • Animal Testing

    Mutated Mutations (And Other Rodent Study Problems)

    Here’s one for the “Dang it, now I have to think about that, too” file. A recent paper suggests that there are mutations in many genetically modified mouse models that could well be confounding their phenotypes. The problem is that so many of these are done from very similar embryonic stem cells and in very… Read More
  • Animal Testing

    Is Everything Getting Fatter?

    Here’s a weird and interesting paper to think about. There’s an unfortunately clear trend in human populations towards obesity, which seems to have been especially noticeable over the last thirty years or so. (I believe that the average-thinnest US state today would have been the fattest state in 1980, just to give one vivid example).… Read More
  • Animal Testing

    Organ Models on Chips

    Why do we test new drug candidates on animals? The simple answer is that there’s nothing else like an animal. There are clearly chemical and biological features of living systems that we don’t yet understand, or even realize exist – the discovery of things like siRNAs is enough proof of that. So you’re not going… Read More
  • Animal Testing

    Whatever Happened to the Fish and the Frogs?

    Eight or ten years ago, there was a good deal of excitement about non-mammalian small animal model systems for compound screening – specifically fish and frogs. More specifically, zebrafish and Xenopus. A number of small companies started up to do this sort of thing, and large companies paid attention as well. A correspondent, though, wrote… Read More
  • Animal Testing

    Near-Animal, Near-Human: The Future of Drug Testing?

    Here’s a good article on animal models in drug discovery, and their many limitations. We have moved away from studying human disease in humans,” (Elias) Zerhouni lamented to the NIH’s Scientific Review Management Board meeting. “We all drank the Kool-Aid on that one, me included.” “The problem is that it hasn’t worked, and it’s… Read More