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Posts tagged with "Animal Testing"

  • Animal Testing

    Mouse Models of Inflammation: Wrong Or Not?

    I wrote here about a study that suggested that mice are a poor model for human inflammation. That paper created quite a splash – many research groups had experienced problems in this area, and this work seemed to offer a compelling reason for why that should happen. Well, let the arguing commence, because now there’s… Read More
  • Animal Testing

    Animal Testing in the UK.

    A reader sends along news that a minister at the UK’s Home Office has made it his goal to completely eliminate animal testing in the country. Norman Baker has been a longtime activist on the issue of animal rights, and is now in a position to do something about it. Or is he? Reading the… Read More
  • Animal Testing

    Mice Hate Men

    The difficulty of doing good animal studies has come up here many times, such as the recent suggestion that many rodent facilities should adjust their thermostats. Now comes word of yet another subtle effect that no one has ever controlled for: mice apparently react different to the scent of human males as compared to human… Read More
  • Animal Testing

    A Call For Better Mouse Studies

    Here’s an article by Steve Perrin, at the ALS Therapy Development Institute, and you can tell that he’s a pretty frustrated guy. With good reason. That chart shows why. Those are attempted replicates of putative ALS drugs, and you can see that there’s a bit of a discrepancy here and there. One problem is poorly… Read More
  • Animal Testing

    Lab Mice Are Being Kept Too Cold, Apparently

    Earlier, the unsuitability of mice in inflammation models was shown in a paper that should have been noted by anyone in the field. Just last month, a paper in Science detailed the problems with many animal studies (mouse and otherwise), particularly the smaller ones, which can suffer from bad statistics and poor protocols. Now we… Read More
  • Animal Testing

    Of Mice (Studies) and Men

    Here’s an article from Science on the problems with mouse models of disease. or years, researchers, pharmaceutical companies, drug regulators, and even the general public have lamented how rarely therapies that cure animals do much of anything for humans. Much attention has focused on whether mice with different diseases accurately reflect wh… Read More
  • Animal Testing

    Mouse Models of Inflammation Are Basically Worthless. Now We Know.

    We go through a lot of mice in this business. They’re generally the first animal that a potential drug runs up against: in almost every case, you dose mice to check pharmacokinetics (blood levels and duration), and many areas have key disease models that run in mice as well. That’s because we know a lot… Read More
  • Animal Testing

    Lab Animals Wiped Out in Hurricane Sandy

    When I mentioned the people working in the research animal facilities before Hurricane Sandy, I had no idea that this was going to happen: thousands of genetically engineered and/or specially bred rodents were lost from an NYU facility due to flooding. The Fishell lab appears to have lost its entire stock of 2,500 mice, representing… Read More
  • Animal Testing

    The Mouse Trap

    If you haven’t seen it, this series by Daniel Engber at Slate, on the use of the mouse as a laboratory workhorse, is excellent. (And I’m not just saying that because he references some of my disparaging comments about xenograft models, although that did give me a chance to teach my kids what the word… Read More
  • Animal Testing

    Reboxetine Doesn’t Work. But That’s Not the Real Problem.

    Some time ago, I took nominations for Least Useful Animal Models. There were a number of good candidates, many of them from the CNS field. A recent report makes me think that these are even stronger contenders than I thought. The antidepressant reboxetine (not approved in the US, but sold in a number of other… Read More
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