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Posts tagged with "Animal Testing"

  • Animal Testing

    Cancer Cells: Too Unstable For Fine Targeting?

    The topic of new drugs for cancer has come up repeatedly around here – and naturally enough, considering how big a focus it is for the industry. Most forms of cancer are the very definition of “unmet medical need”, and the field has plenty of possible drug targets to address. But we’ve been addressing many… Read More
  • Animal Testing

    Charles River Buys WuXi

    I don’t think we saw this one coming: Charles River Labs has announced that they’re buying WuXi PharmaTech. They’re paying about a 28% premium over Friday’s closing stock price – Charles River’s CEO will stay on, and WuXi’s founder (Li Ge) will serve as executive VP under him. Charles River, which is strong… Read More
  • Animal Testing

    Animal Studies: Are Too Many Never Published At All?

    A new paper in PLoS Biology looks at animal model studies reported for the treatment of stroke. The authors use statistical techniques to try to estimate how many have gone unreported. From a database with 525 sources, covering 16 different attempted therapies (which together come to 1,359 experiments and 19,956 animals), they find that only… Read More
  • Animal Testing

    Fat Rats Make Poor Test Subjects?

    Well, here’s a brow-furrowing paper, courtesy of PNAS. Th authors, from the National Institute on Aging, contend that most laboratory rodents are overfed, under-stimulated, and are (to use their phrase) “metabolically morbid”. This affects their suitability as control and experimental animals for a wide variety of assays. There se… Read More
  • Animal Testing

    Animal Testing: A View From the Labs

    Why do we test drugs on animals, anyway? This question showed up in the comments section from a lay reader. It’s definitely a fair thing to ask, and you’d expect that we in the business would have a good answer. So here it is: because for all we know about biochemistry, about physiology and about… Read More
  • Animal Testing

    Animal Rights, You Say?

    Novartis has had trouble for years with animal rights activists, and now things are getting nastier than ever: Novartis CEO Daniel Vasella says the people who burned down his holiday home and defiled his family’s graves are not criminals but “terrorists” beyond dialogue. In an interview with the SonntagsBlick newspaper, the 55-yea… Read More
  • Animal Testing

    Animal Models: How High to Set the Bar?

    A key step in all drug discovery programs are the cellular and animal models. The cells are the first time that the compounds are exposed to a living system (with cellular membranes that keep things out). The animals, of course, are a very stringent test indeed, with the full inventory of absorption, metabolism, and excretion… Read More
  • Animal Testing

    Whose Guess Is Better?

    I was having a discussion the other day about which therapeutic areas have the best predictive assays. That is, what diseases can you be reasonably sure of treating before your drug candidate gets into (costly) human trials? As we went on, things settled out roughly like this: Cardiovascular (circulatory): not so bad. We’ve got a… Read More
  • Animal Testing

    The Animal Testing Hierarchy

    I’ve had some questions about animal models and testing, so I thought I’d go over the general picture. As far as I can tell, my experience has been pretty representative. There are plenty of animal models used in my line of work, but some of them you see more than others. Mice and rats are… Read More
  • Animal Testing

    Unacceptable

    I’ve had reports that some of the animal rights activists are getting loud and lively down in Connecticut, to the point of harassing employees of some of the drug companies there. I remember some of this going on in the early 1990s in New Jersey, but this is the first big outbreak of this stuff… Read More
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