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Posts tagged with "Animal Testing"

  • Animal Testing

    Less Than Zero

    When I wrote about lousy animal models of disease a few days ago, there was a general principle at the back of my mind. (There generally is – my wife, over the years, has become accustomed to the sudden dolly-back panorama shots that appear unannounced in my conversation). It was: that a bad model system… Read More
  • Animal Testing

    Worst Animal Model: Nominations Are Open

    I was talking to someone the other day about animal models, and that got me to thinking: there are several therapeutic areas with reasonably good ones, but which indication has the most useless ones? Naturally, just getting a compound into mice or what have you is going to tell you a lot that you’d never… Read More
  • Animal Testing

    Formally Undecideable

    A comment to the last post asked a good question, one that occurs to everyone in the drug industry early in their career: how many useful drugs do we lose due to falsely alarming toxicity results in animals? The answer is, naturally, that we don’t know, and we can’t. Not in the world as we… Read More
  • Animal Testing

    Rats Rule, Right?

    So, you’re developing a drug candidate. You’ve settled on what looks like a good compound – it has the activity you want in your mouse model of the disease, it’s not too hard to make, and it’s not toxic. Everything looks fine. Except. . .one slight problem. Although the compound has good blood levels in… Read More
  • Animal Testing

    Ends, Means, Rats, and Dogs

    Many readers will have heard of the years-long campaign in England against Huntingdon Life Sciences, a research animal breeding and testing company. (These tug-of-war articles from Wikipedia on HLS and the campaign against it are detailed overviews, as well as a good example of that site’s simultaneous strengths and weaknesses). Now sharehold… Read More
  • Animal Testing

    Model Systems, From Inside and Out

    I’ve mentioned before that one of our big problems in the drug industry seems to be finding compounds that work in man. I know, that sounds pretty obvious, but the statement improves when you consider the reasons why compounds fail. Recent studies have suggested that these days, fewer compounds are failing through some of the… Read More
  • Animal Testing

    Furry Judges, With Tails

    The phrase “guinea pig” entered the language a long time ago as slang for “test animal”, but I’ve yet to make a compound that’s crossed a guinea pig’s lips. Guinea pigs are still used for a few special applications, but since the beginning of my career, I’ve been surrounded (metaphorically!) by rats a… Read More
  • Animal Testing

    What to Do When the Rats Die on You

    I’ve had some e-mail asking if the diabetes drug I mentioned the other day is dead or not, and if not, why not. I don’t have any direct contacts in the companies involved, not that they’d tell me all about it even if I did, but I can make some informed guesses. They’ll illustrate what… Read More
  • Animal Testing

    Rats, For Fear of Worse

    I’ve had some mail asking a good (and Frequently Asked) question: how good are the alternatives to animal testing? How close are we to not dosing animals to get toxicology information? My short answer to the second question is, simultaneously, “A lot closer than we used to be” and “Not very close, for all that.” Read More
  • Animal Testing

    You’ll Only Get Answers

    I mentioned the other day that I’ve usually had a good response when I tell people about what I do for a living. There are exceptions, though. A few years ago, my wife and I were walking through a shopping mall, when we were stopped by two scruffy teenage survey takers. “Would you like to… Read More
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