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  • Calcium Probe Problems

    Fluorescent dyes and probes are wonderful things, and they have been absolutely crucial to our understanding of cellular biology. Being able to see specific pro… Read More
  • A Close Look at Protein Head Counts

    So how many proteins are there in a living cell? Not how many different proteins, although that’s a pretty good question all by itself, one that’s b… Read More
  • The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Mu… Read More
  • Mistreating Enzymes For a Good Cause

    What happens when you chuck an active enzyme into the wrong solvent? Well, it stops working (or at the very least, it stops working as well as it did). And how… Read More
  • CRISPR: The Latest Edition

    There’s a rather large breakthrough in CRISPR gene editing – yeah, another one – that has downstream implications for drug discovery. A group… Read More
  • Small Proteins: Into the Gap

    We medicinal chemists are used to thinking about small molecule drugs – it’s what we do. And we’re also comfortable with having a category in… Read More
  • Bad Cells. So Many Bad Cells.

    Let’s file this one under “We’ve seen this before, and I’ll bet we’ll see it again”. Anyone who’s worked for some year… Read More
  • A Nobel for Cryo-EM

    The Chemistry Nobel committee seems to have taken everyone by surprise today with their award for cryo-electron microscopy (cryo-EM). That’s not because i… Read More
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