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Posts tagged with "Biological News"

  • Biological News

    Alarmingly Functional Disorder

    Let’s think for a bit about how proteins bind to each other. After all, messing around with that is what keeps everyone in the drug industry employed, and the unmessed varieties of such binding events are what keep us all vertical and above room temperature, so it’s a worthy subject. The mental picture is of… Read More
  • Biological News

    Zap the Zinc

    Zinc – can’t live without it, can’t get rid of it. That about sums up the situation with trying to figure out the metal’s many important roles in biology. A long, long list of proteins have zinc-binding functions (with the metalloproteases and the DNA-binding zinc-finger domains being two important ones that immediately come… Read More
  • Analytical Chemistry

    Calcium Probe Problems

    Fluorescent dyes and probes are wonderful things, and they have been absolutely crucial to our understanding of cellular biology. Being able to see specific protein types and cellular structures in real time through a microscope with dyes, being able to monitor things like calcium flux, oxidative stress, pH and so on through fluorescent probe molec… Read More
  • Biological News

    A Close Look at Protein Head Counts

    So how many proteins are there in a living cell? Not how many different proteins, although that’s a pretty good question all by itself, one that’s been investigated pretty thoroughly. But how many actual protein molecules are there of each of those? This new paper is the latest attempt to answer that one, from the… Read More
  • Biological News

    The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Munich) characterize 243 (!) kinase inhibitors that have made it into human trials across a very wide range of the known kinase enzymes, and the result is… Read More
  • Biological News

    Mistreating Enzymes For a Good Cause

    What happens when you chuck an active enzyme into the wrong solvent? Well, it stops working (or at the very least, it stops working as well as it did). And how do you know which one is the wrong solvent? Why, those are the ones that make it stop working. That round trip is to… Read More
  • Biological News

    CRISPR and Axovant: What the Market Thinks

    Let’s go to the NASDAQ for some insight on a couple of recent biopharma stories. First off is Axovant, a company that’s interesting in a number of distressing ways. I last wrote about them here, after their Alzheimer’s candidate came up short in the clinic, which was a development that surprised no one who had… Read More
  • Biological News

    Genetic Variation Gets More Real All the Time

    This study goes firmly into the file marked “You never could have done this one a few years ago, sonny”. We already know that there’s genetic variation in every population and in every individual. And we know that a large number of marketed drugs (about a third of them) target G-protein coupled receptors (GPCRs). But… Read More
  • Biological News

    CRISPR: The Latest Edition

    There’s a rather large breakthrough in CRISPR gene editing – yeah, another one – that has downstream implications for drug discovery. A group at the Salk Institute reports in Cell that they’ve found a way to do both loss- and gain-of-function without double-stranded DNA breaking. That’s quite different from the various… Read More
  • Biological News

    Small Proteins: Into the Gap

    We medicinal chemists are used to thinking about small molecule drugs – it’s what we do. And we’re also comfortable with having a category in our worldview that we assign to “biologics” – proteins, mostly, many of them antibodies, which can also be extremely therapeutically effective under the right conditions. B… Read More
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