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Posts tagged with "Biological News"

  • Biological News

    A New Cell Assay -And What It Says About Stapled Peptides

    I’m always looking out for new assays that might tell us what the heck is going on inside cells, so this paper caught my eye. The authors describe a new luciferase-based complementation assay for detecting protein-protein interactions. There are several things like this in the literature already (and for sale, too), but this one has… Read More
  • Aging and Lifespan

    Ibuprofen For a Longer Life?

    Here’s one that I didn’t expect: a report that ibuprofen extends lifespan in model organisms. Here we show that ibuprofen increased the lifespan of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster, indicative of conserved eukaryotic longevity effects. Studies in yeast indicate that ibuprofen destabilizes the… Read More
  • Biological News

    J. Already Known Chem.

    A reader sent along this paper, which recently appeared in JACS. He’d read it and was puzzled – not by the content of the paper, but as to “how it got into JACS”. So I had a look. It’s on the peptide hormone oxyntomodulin, a 37-residue species closely related to glucagon which stimulates insulin release… Read More
  • Biological News

    Cells In Disguise

    This is a good read for anyone who’s depending on cell assays to tell them something useful. Longtime cell biologists will know that there have been several upheavals over the years about misidentified or contaminated cell lines. HeLa cells have been involved in several of these, as well as mycoplasma and other unwanted guests. In… Read More
  • Biological News

    Who Owns CRISPR?

    Update: see also this post at Xconomy for a look at this issue. CRISPR/Cas9 is an excellent technique for gene manipulation. Its discovery is absolutely going to be the subject of a Nobel prize; I think it’s pretty much of a lock. But at the moment, there’s a vicious legal fight going on over who… Read More
  • Biological News

    Cambrian Genomics Does It All

    I’d like to echo this question over at Chemjobber’s blog. What is Cambrian Genomics talking about? For example, see this Q&A: How do you plan to stop people from using your technology to create very dangerous microorganisms? Virtualization. Instead of mailing out DNA we will send the DNA to a virtualization center like Transcriptic… Read More
  • Animal Testing

    Near-Animal, Near-Human: The Future of Drug Testing?

    Here’s a good article on animal models in drug discovery, and their many limitations. We have moved away from studying human disease in humans,” (Elias) Zerhouni lamented to the NIH’s Scientific Review Management Board meeting. “We all drank the Kool-Aid on that one, me included.” “The problem is that it hasn’t worked, and it’s… Read More
  • Biological News

    Knockout Models

    Did you know that we already have a supply of human genetic knockout models for disease? No, they haven’t been generated in an underground lab in North Korea; they’re walking around everywhere as part of the natural genetic variability of our species. And it’s now feasible to track them down, as this Nature News article… Read More
  • Biological News

    Splitting the Junk DNA Difference

    A big dispute erupted in the genomics world in 2012 with the publication of the ENCODE consortium’s data – and with their interpretation of it. How much of the human genome is functional? And just what does “functional” mean? The ENCODE folks, or at least many of them, claim that 70 or 80% of the… Read More
  • Biological News

    Down With the Western Blot?

    A reader sends along a thought that touches on a lot of the publication scandals that have happened in molecular biology over the years. A very common feature of these is manipulation of Western blots (see that graphic the other day on the Sarkar case, assembled by a reader of Retraction Watch who goes under… Read More