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Posts tagged with "Biological News"

  • Biological News

    Ciliobrevins: Digging Into Cell Biology

    Back in 2009 I wrote about a paper that found a number of small (and ugly) molecules which affected the Hedgehog signaling pathway. At the time, I asked if anyone had done any selectivity studies with them, or looked for any SAR around them, because they didn’t look very promising to me. I’m glad to… Read More
  • Biological News

    The Ultimate in Personalized Medicine

    I wanted to mention this news, since it’s really the most wildly advanced form of “personalized medicine” that the world has yet seen. As detailed in this paper, Stanford professor Michael Snyder spent months taking multiple, powerful, wide-ranging looks at his own biochemistry: genomic sequences, metabolite levels, microRNAs, gen… Read More
  • Biological News

    Roche Goes Hostile for Illumina

    Roche is not only a big drug company, it’s a big diagnostics company. And that’s what’s driving their unsolicited bid for Illumina, a gene-sequencing company from San Diego. Illumina has been one of the big players in the “How quickly and cheaply can we sequence a person’s entire genome” game, and apparently Roch… Read More
  • Biological News

    Fun With Epigenetics

    If you’ve been looking around the literature over the last couple of years, you’ll have seen an awful lot of excitement about epigenetic mechanisms. (Here’s a whole book on that very subject, for the hard core). Just do a Google search with “epigenetic” and “drug discovery” in it, any combination you like,… Read More
  • Biological News

    Warp Drive Bio: Best Name or Worst?

    There are small drug firms and there are small drug firms – if you know what I mean. Which category is Warp Drive Bio going to fall into? If you’ve never heard of them – and that name is rather memorable – then don’t worry, they’re new. Its founders are big names on the industry/academic… Read More
  • Biological News

    Osiris And Their Stem Cells

    The topic of whether stem-cell therapies are overhyped – OK, let me show my cards, the topic of just how overhyped they are – last came up around here in November, when Geron announced that they were getting out of the business. And yesterday had a good example of why people tend to hold their… Read More
  • Biological News

    Brain Cells: Different From Each Other, But Similar to Something Else?

    Just how different is one brain cell from another? I mean, every cell in our body has the same genome, so the differences in type (various neurons, glial cells) must be due to expression during development. And the differences between individual members of a class must be all due to local environment and growth – Read More
  • Analytical Chemistry

    Proteins in a Living Cell

    It’s messy inside a cell. The closer we look, the more seems to be going on. And now there’s a closer look than ever at the state of proteins inside a common human cell line, and it does nothing but increase your appreciation for the whole process. The authors have run one of these experiments… Read More
  • Biological News

    Geron, Stem-Cell Pioneers, Drop Stem Cells

    Are stem cells overhyped? That topic has come up around here several times. But there have been headlines and more headlines, and breathless reports of advances, some of which might be working out, and many of which are never heard from again. (This review, just out today, attempts to separate reality from hype). Today brings… Read More
  • Biological News

    Cyclodextrin’s Day in the Sun

    Under the “Who’da thought?” category, put this news about cyclodextrin. For those outside the field, that’s a ring of glucose molecules, strung end to end like a necklace. (Three-dimensionally, it’s a lot more like a thick-cut onion ring – see that link for a picture). The most common form, beta-cyclodextrin, has… Read More