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Posts tagged with "Biological News"

  • Analytical Chemistry

    Proteins in a Living Cell

    It’s messy inside a cell. The closer we look, the more seems to be going on. And now there’s a closer look than ever at the state of proteins inside a common human cell line, and it does nothing but increase your appreciation for the whole process. The authors have run one of these experiments… Read More
  • Biological News

    Geron, Stem-Cell Pioneers, Drop Stem Cells

    Are stem cells overhyped? That topic has come up around here several times. But there have been headlines and more headlines, and breathless reports of advances, some of which might be working out, and many of which are never heard from again. (This review, just out today, attempts to separate reality from hype). Today brings… Read More
  • Biological News

    Cyclodextrin’s Day in the Sun

    Under the “Who’da thought?” category, put this news about cyclodextrin. For those outside the field, that’s a ring of glucose molecules, strung end to end like a necklace. (Three-dimensionally, it’s a lot more like a thick-cut onion ring – see that link for a picture). The most common form, beta-cyclodextrin, has… Read More
  • Aging and Lifespan

    The Latest Sirtuin Controversy

    As promised, today we have a look at a possible bombshell in longevity research and sirtuins. Again. This field is going to make a pretty interesting book at some point, but it’s one that I’d wait a while to start writing, because the dust is hanging around pretty thickly. Some background: in 1999, Sir2 the… Read More
  • Aging and Lifespan

    Big Sirtuin News

    This will be the subject of a longer post tomorrow, but I wanted to alert people to some breaking news in the sirtuin/longevity saga. It now appears that the original 2001 report of longevity effects of Sir2 in the C. elegans model, which was the starting gun of the whole story, is largely incorrect. That… Read More
  • Biological News

    Merck, RNAi, Alnylam, And So On

    And while we’re on the topic of Merck, I note that they’re closing their RNAi facility in Mission Bay, the former Sirna. That was a pretty big deal when it took place, wasn’t it? The piece linked to in that earlier post also talks about the investment that Merck was making in the very facility… Read More
  • Biological News

    Bait And Switch For Type B GPCRs

    You hear often about how many marketed drugs target G-protein coupled receptors (GPCRs). And it’s true, but not all GPCRs are created equal. There’s a family of them (the Class B receptors) that has a number of important drug targets in it, but getting small-molecule drugs to hit them has been a real chore. There’s… Read More
  • Biological News

    A First Step Toward A New Form of Life

    There’s been a real advance in the field of engineered “unnatural life”, but it hasn’t produced one-hundredth the headlines that the arsenic bacteria story did. This work is a lot more solid, although it’s hard to summarize in a snappy way. Everyone knows about the four bases of DNA (A, T, C, G). What this… Read More
  • Biological News

    The Histamine Code, You Say?

    I’ve been meaning to link to John LaMattina’s blog for some time now. He’s a former R&D guy (and author of Drug Truths: Dispelling the Myths About Pharma R & D, which I reviewed here for Nature Chemistry), and he knows what he’s talking about when it comes to med-chem and drug development. Here he… Read More
  • Biological News

    The Uses of Disorder

    We spend a lot of time thinking about proteins in this business – after all, they’re the targets for almost every known drug. One of the puzzling things about them, though, is the question of just how orderly they are. That’s “order” as in “ordered structure”. If you’re used to seeing proteins in X-ra… Read More