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Posts tagged with "Biological News"

  • Analytical Chemistry

    Epigenetics Is Not What You Would Call a Settled Field

    Everyone knows the canonical bases of the nucleic acids. Well, OK, not every single person, but a whole of lot of people do, and I’m willing to bet that if you stopped a bunch of random strangers, you’d get more “A, T, C, G” answers than you might think, thanks to movies and popular culture. Read More
  • Biological News

    MELK Is Not A Cancer Target. Surprise!

    The Maternal Embryonic Leucine zipper Kinase (MELK) is definitely an interesting enzyme. It’s been implicated in a number of cancer cell lines, and it also has important roles in the normal cell cycle, in embryogenesis, and other functions. It’s one of those proteins that’s found all across mammalian (and non-mammalian) species,… Read More
  • Biological News

    Hope For Nonaddictive Opioid Painkillers

    No one needs to be told about the opioid painkiller problem in this country. There are legal, commerical, regulatory, and ethical ways to look at it, but from a pharmacological standpoint, the whole thing would be a lot easier to deal with if there were any highly effective non-addictive painkillers. But that’s exactly what we… Read More
  • Biological News

    Gene Therapy Needs Machines

    News came recently of an apparent cure, via gene therapy, of sickle-cell disease in a young patient (whose condition was refractory to hydroxyurea and the other standards of care). Blood-cell diseases are naturally one of the main proving grounds for things like this, since their stem cell populations are in easily localizable tissues and the… Read More
  • Biological News

    The Microbiome and Human Obesity: Wait a Minute

    For the last few years, it has been impossible to escape talk of the microbiome – the associated bacteria (and other organisms) that live in and on the human body. Overall, this attention has been a good thing, since it’s made people aware of just how bacteria-laden we are (not that everyone finds that a… Read More
  • Biological News

    Fragment Screening in Cells – It’s Great

    I’ve very much been enjoying this paper, on fragment-based chemogenomics in whole cells. That’s the sort of blurb, I admit, that’s probably going to make you immediately want to read the rest of the paper, or immediately go do something else (all the way up to “podiatrist appointment”). And I understand those impulses. Read More
  • Biological News

    A First Look at Reproducibility in Cancer Biology

    I’ve been waiting for these results: the Reproducibility Project (Cancer Biology) has been going back over several prominent papers in the field, seeing how well their results hold up. This follows a similar effort in experimental psychology, where the results were mixed. The hopes here were to reproduce 50 high-profile studies, but as this N… Read More
  • Biological News

    Is Selective Ribosome Stalling Possible? Apparently So

    PCSK9 is a drug target that’s famous in several directions. If you’re interesting in human genetics, it’s famous as an example of a “human knockout” – people with nonfunctional PCSK9, and there are a handful, have extraordinarily low levels of LDL, a finding that immediately got drug companies interested in findi… Read More
  • Alzheimer's Disease

    The Limits of Big Data

    I fear that mentioning the phrase “Big Data” in the first sentence of a blog post will make half the potential readers suddenly remember that they have podiatrist appointments or something. But that’s the only way to approach this article at Wired. After all, the title is “The Cure For Cancer is Data – Mountains of… Read More
  • Biological News

    How We Smell Those Delightful Little Sulfur Compounds

    We humans have a huge number of different smell receptors, but some of the most famous are the ones that are sensitive to thiols. We don’t miss out on many low oxidation state sulfur compounds: S-alkyl and SH groups reek to the skies as far as our noses are concerned (as do the corresponding selenium… Read More