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Posts tagged with "Biological News"

  • Biological News

    Trouble with CRISPR? Maybe, But Maybe Not

    Now, here is a paper that is causing a stir. Published in Nature Methods, researchers from Stanford, the University of Iowa, and Colombia are reporting that CRISPR treatment in mice introduces far more mutations than thought. The news sent the stocks of companies like Editas and CRISPR Therapeutics dropping yesterday, and has led to consternation… Read More
  • Biological News

    Making Sure of the Chemistry in Chemical Biology

    There are a lot of interesting and useful experiments you can do to test interactions with DNA in the living cell. Chromatin Immunoprecipitation Sequencing (ChIP-Seq) is a well-known one to spot protein-DNA interactions, and the graphic at right (from the Swiss Institute of Bioinformatics) will show you broadly how it works. Proteins that are inter… Read More
  • Biological News

    A Look at Antibody Therapies

    Since we were just talking about antibody therapies in immuno-oncology, here’s a timely column by Bruce Booth at LifeSciVC on antibody therapies in general. It’s well worth a read if, like many small-molecule drug discovery folks, you haven’t had to keep up with that area. I’ve written a few times over the years about how… Read More
  • Biological News

    Turmoil in Immuno-oncology

    Immuno-oncology! It’s such a big deal, let’s just do what everyone in the field is doing and call it “IO”. The recent successes in this area have rearranged every company’s oncology strategy, in some cases rearranging its entire oncology portfolio right out the door. There are several possibilities open to you now, if… Read More
  • Biological News

    Silently Affecting the Immune System?

    Here’s a new paper in Nature Chemical Biology that might be lifting the lid on a poorly-understood set of side effects. A multi-institution team (centered in Vienna) has taken peripheral blood mononuclear cells (PBMCs, basically the leukocytes and monocytes) from a single patient and looked for immunomodulatory effects of known drugs. (The si… Read More
  • Analytical Chemistry

    Epigenetics Is Not What You Would Call a Settled Field

    Everyone knows the canonical bases of the nucleic acids. Well, OK, not every single person, but a whole of lot of people do, and I’m willing to bet that if you stopped a bunch of random strangers, you’d get more “A, T, C, G” answers than you might think, thanks to movies and popular culture. Read More
  • Biological News

    MELK Is Not A Cancer Target. Surprise!

    The Maternal Embryonic Leucine zipper Kinase (MELK) is definitely an interesting enzyme. It’s been implicated in a number of cancer cell lines, and it also has important roles in the normal cell cycle, in embryogenesis, and other functions. It’s one of those proteins that’s found all across mammalian (and non-mammalian) species,… Read More
  • Biological News

    Hope For Nonaddictive Opioid Painkillers

    No one needs to be told about the opioid painkiller problem in this country. There are legal, commerical, regulatory, and ethical ways to look at it, but from a pharmacological standpoint, the whole thing would be a lot easier to deal with if there were any highly effective non-addictive painkillers. But that’s exactly what we… Read More
  • Biological News

    Gene Therapy Needs Machines

    News came recently of an apparent cure, via gene therapy, of sickle-cell disease in a young patient (whose condition was refractory to hydroxyurea and the other standards of care). Blood-cell diseases are naturally one of the main proving grounds for things like this, since their stem cell populations are in easily localizable tissues and the… Read More
  • Biological News

    The Microbiome and Human Obesity: Wait a Minute

    For the last few years, it has been impossible to escape talk of the microbiome – the associated bacteria (and other organisms) that live in and on the human body. Overall, this attention has been a good thing, since it’s made people aware of just how bacteria-laden we are (not that everyone finds that a… Read More