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Posts tagged with "Business and Markets"

  • Business and Markets

    Marathon Pharmaceuticals Cashes Out

    You may recall Marathon Pharmaceuticals, the small company that announced plans to sell a long-used steroid treatment (Emflaza, deflazacort) in the US to Duchenne muscular dystrophy patients. The price was set to go up steeply, since the company was awarded years of market exclusivity by the FDA (under their program to reward orphan-drug indication… Read More
  • Business and Markets

    Lose Money Now! Ask Me How!

    Some readers will remember some odd moves in small biotechs like Galena Biosciences, Cytrx, and Lion Biotechnologies, among others. It can be hard to keep track, because there’s a lot of odd behavior down in those companies (here’s another recent example with Cyclacel). Here’s a welcome update to the earlier stories, courtesy of t… Read More
  • Business and Markets

    Bill Ackman, Pompey, and You

    It’s been about a year since Valeant Pharmaceuticals fell apart into a pile of smoldering rubble. As that link details, its biggest investor and biggest fan, Bill Ackman, was at that point down several billion dollars on the investment, and things did not get any better. His fund sold out of its Valeant position last… Read More
  • Business and Markets

    PCSK9: Real World Data Arrives, Unfortunately

    So, PCSK9. A wonderful story of genetics-based drug discovery, and a huge commercial opportunity. People with loss-of-function PCSK9 genes have very low LDL cholesterol, with no other ill effects, and people with gain-of-function mutations have chronically high cholesterol. That’s about as good as the validation gets, so a number of drug co… Read More
  • Business and Markets

    PARP Inhibitors Do It Again

    When we last looked in on the long-running saga of PARP inhibitors around here, Tesaro had posted excellent clinical results for their compound and re-invigorated the whole field. At the time, I wrote “It’ll be quite interesting to see the clinical results of the other PARP compounds in this light. You’d expect more differences to… Read More
  • Business and Markets

    The Soon-Shiong Hype Machine

    I have long been suspicious of people who use the word “moonshot” in the context of biomedical research. It’s lazy shorthand for “We’re going to spend a lot of money in a shorter period of time than usual”, and (as has been pointed out time without number), that approach was pretty suitable for the Apollo… Read More
  • Business and Markets

    Marathon’s Real Costs

    Endpoints has done a great breakdown on the actual costs that Marathon Pharmaceuticals is likely to have incurred while bringing their wildly overpriced old generic steroid to the US market. They did no new registrational studies in the clinic, in case you’re wondering. There was a drug-drug interaction study, ADME work, that sort of thing… Read More
  • Business and Markets

    Not Quite What Friends Are For

    Folks who do industrial drug research know that they’re around proprietary information, and they generally know to keep quiet about it. That can be a bit of an odd feeling at first – I can remember getting together with some friends from school not long after I’d taken my first pharma job (they had also… Read More
  • Business and Markets

    Thoughts on Corruption

    I’ve had many questions about what I think of the PhARMA meeting with the new administration, but I haven’t written about it yet. That’s largely because it’s been difficult to figure out what it actually accomplished – statements about it have been all over the place, and I get the impression that different people took… Read More
  • Alzheimer's Disease

    Eli Lilly Is a Biologics Company

    The news from Eli Lilly is not good – they’re laying off 485 people, according to filings with the state, and it appears to be completely a result of their latest Alzheimer’s clinical failures. The positions are largely in the company’s sales and marketing area. According to that article from FiercePharma, the company had be… Read More
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