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Posts tagged with "Cancer"

  • Business and Markets

    One Of Those Binary Events for AbbVie

    Back in late 2015, I wrote about cancer stem cells, the idea that some tumors are driven by populations of slow-dividing stem cells. The theory has been that these are always going to be in there fighting against your efforts to kill off the downstream tumor cells, so unless you find a way to target… Read More
  • Business and Markets

    Pay Your Money and Hold Your Breath

    In another example of the white-knuckle here-we-go nature of the drug business, Bristol-Myers Squibb announced this morning that they’re doing a huge deal with Nektar Therapeutics for their immune stimulant drug candidate, NKTR-214. Well, actually, they’re not getting the drug, because the development deal is non-exclusive. And theyR… Read More
  • Cancer

    The Next Immuno-oncology Frontier?

    Here’s some strong evidence for what could be the next wave of immuno-oncology: combining a TLR9 ligand with an OX40 antibody. We’re all going to have to get familiar with that sort of talk, so here’s what’s going on: As those who have worked in inflammation or infectious disease know well, the TLRs (Toll-like receptors) Read More
  • Business and Markets

    Bristol-Myers Squibb Sows Confusion

    Yesterday was a weird day for Bristol-Myers Squibb. The company announced the results of a highly anticipated clinical trial, one combining Opdivo (nivolumab) and Yervoy (ipilimumab) in lung cancer patients. As those who follow this area know, BMS has been losing ground to Merck for the last year or two, as Merck’s Keytruda (pembrolizumab) ma… Read More
  • Cancer

    A Hard Look At Liquid Biopsies

    This new paper has generated a lot of headlines (Science news writeup here). It reports work on the long-sought “liquid biopsy” idea for cancer screening, the use of circulating biomarkers to detect tumors via a blood test. The idea has obvious appeal, so much appeal that many news stories over the years have gotten well… Read More
  • Biological News

    The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Munich) characterize 243 (!) kinase inhibitors that have made it into human trials across a very wide range of the known kinase enzymes, and the result is… Read More
  • Cancer

    Bacteria and Cancer: Another Connection

    Three months ago, I wrote about a report that some kinds of pancreatic cancer seem to be associated with particular infections, and wondered “How many similar stories are out there that we don’t know about yet?” Well, that didn’t take long to start being answered. This recent paper in Science (from a multicenter team: Dana- Read More
  • Cancer

    Watch Your Covalent Drugs Carefully

    EGFR is a growth-factor receptor protein that’s well known as a cancer target, and there are a number of drugs that target its kinase activity in order to shut it down. But as is also well known, many cancer cells are rather genomically unstable, and throw off mutations constantly. One of the most common problems… Read More
  • Cancer

    A Painful, Unacceptable Lack of Data

    Okay, this paper is not going to make a lot of people happy. The authors are reviewing oncology approvals by the European Medicines Agency (EMA) from 2009 to 2013 – overall, there were 48 drugs approved for 68 indications, which sounds like good news. 24 of the 68 were approved with survival benefit shown in… Read More
  • Cancer

    There Are Probes, And There Are Probes

    A friend in the business called my attention to this paper, which is about another piece of the ubiquitination system that I was writing about here just the other day – in this case, the deubiquitinating enzyme Rpn11. There are a couple of classes of deubiquitinators – some of them use a cysteine in their… Read More
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