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Posts tagged with "Cancer"

  • Biological News

    A First Look at Reproducibility in Cancer Biology

    I’ve been waiting for these results: the Reproducibility Project (Cancer Biology) has been going back over several prominent papers in the field, seeing how well their results hold up. This follows a similar effort in experimental psychology, where the results were mixed. The hopes here were to reproduce 50 high-profile studies, but as this N… Read More
  • Cancer

    What Passes For Positive Data

    So can someone explain this one for me? Halozyme has a hyaluoronidase enzyme (PEGPH20) that they’re developing as a therapeutic agent. The idea is that it’s going to be an add-on with other cancer therapeutic combinations, and would increase the exposure of the tumor cells to the actual chemotherapies by breaking down hyaluronan (hyalur… Read More
  • Alzheimer's Disease

    Clinical Trials, Up and Very Much Down

    Lots of news at both ends of the scale today. At the bad end would be Arrowhead Pharma, who have been exploring therapeutic RNA interference. That’s a hard row to hoe, and nothing illustrates that better than their announcement that they’re dropping three clinical programs, pretty much all the advanced research that they have, because… Read More
  • Cancer

    More Juno CAR-T Deaths

    Remember back in the summer when Juno Therapeutics disclosed three patient deaths in one of their CAR-T oncology trials and the trial was put on hold? And then the hold was lifted about ten minutes later? OK, three days, but by clinical death standards, that’s pretty fast. Perhaps too fast, because now there have been more… Read More
  • Cancer

    More Than Was Asked For

    Via AndyBiotech on Twitter, here’s an interesting report from the New England Journal of Medicine. It describes a patient diagnosed with follicular lymphoma who also was positive for hepatitis C. They went through a course of Gilead’s sofosbuvir with ribavirin, and that (as it usually does) cleared the Hep C infection. What’s inte… Read More
  • Alzheimer's Disease

    The Limits of Big Data

    I fear that mentioning the phrase “Big Data” in the first sentence of a blog post will make half the potential readers suddenly remember that they have podiatrist appointments or something. But that’s the only way to approach this article at Wired. After all, the title is “The Cure For Cancer is Data – Mountains of… Read More
  • Cancer

    Keytruda vs. Opdivo: No Contest

    You don’t always get to see a head-to-head showdown like this one: Merck’s Keytruda (pembrolizumab) and Bristol Myers-Squibb’s Opdivo (nivolumab) were both the subject of presentations at the European Society of Medical Oncology conference, reporting on non-small cell lung cancer trials, and there doesn’t seem to be any doub… Read More
  • Cancer

    Better, Faster, More Comprehensive Manure Distribution

    So today brings news that Microsoft is working on curing cancer in the next five or ten years. That, I’m sure, will come as a relief, especially to those people who’ve had the company’s software crash on them recently. For some reason, the UK press is especially susceptible to Amazing Cancer Cure stories (and to… Read More
  • Cancer

    Precision Oncology Isn’t Quite There Yet

    Here’s a gauntlet thrown down – let’s see how many people show up to the duel. Vinay Prasad has a piece in Nature titled “The Precision Oncology Illusion”, with the subhead saying “Precision oncology has not been shown to work, and perhaps it never will”. (Here’s Prasad earlier this year, with co-auth… Read More
  • Cancer

    Pancreatic Cancer Progress? Maybe

    There’s been a vast amount of work (and excitement) in the immunotherapy approaches to cancer in the last few years. Here’s a report on one that I’d missed: IMM-101, which is not directed to PD-1 or PD-1L1, not an engineered T-cell, or any of the other things that have been in the news. It’s a… Read More
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