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Posts tagged with "Cardiovascular Disease"

  • Cardiovascular Disease

    Clinical Trial Fraud Uncovered

    Hmmm. This article from Bloomberg says that the BMS/Pfizer anticoagulant Eliquis (apixaban), a Factor Xa inhibitor approved late last year by the FDA, was delayed for months because of misconduct in its Chinese clinical trials. (Its clinical trials had not been without incident even before this). Documents posted by the FDA have the details. Says… Read More
  • Cardiovascular Disease

    An Anticoagulant Antidote

    Here’s a drug-discovery problem that you don’t often have to think about. The anticoagulant field is a huge one, with Plavix, warfarin, and plenty of others jostling for a share of a huge market (both for patients to take themselves, and for hospital use). The Factor Xa inhibitors are a recent entry into this area… Read More
  • Cardiovascular Disease

    Merck’s Liptruzet: A Cause For Shame?

    Vytorin’s been discussed several times around here. The combination of Zetia (ezetimibe), the cholesterol absorption inhibitor discovered at Schering-Plough, with Merck’s simvastatin looked as if it should be a very effective cholesterol-lowering medication, but the real-world data have been consistentlypuzzling. There’s a big tri… Read More
  • Business and Markets

    Regeneron Expands

    I feel as if there should be some good news around here on the hiring front, so when any becomes available I want to try to mention it. So here’s some: Regeneron has announced today that they’re expanding their site in Westchester (NY), adding another 300,000 square feet of lab and office space, and adding… Read More
  • Business and Markets

    Affymax In Trouble

    Affymax has had a long history, and it’s rarely been dull. The company was founded in 1988, back in the very earliest flush of the Combichem era, and in its early years it (along with Pharmacopeia) was what people thought of when they thought of that whole approach. Huge compound libraries produced (as much as… Read More
  • Cardiovascular Disease

    Merck Finally Settles Over Vytorin

    You may remember that Merck and Schering-Plough took a lot of fire for the way that they released the clinical data for one of the key Vytorin trials (ENHANCE). The numbers were delayed for months, and when they were finally released, they were. . .problematic for the drug. And for the companies’ stocks. The institutional… Read More
  • Alzheimer's Disease

    CETP, Alzheimer’s, Monty Hall, and Roulette. And Goats.

    CETP, now there’s a drug target that has incinerated a lot of money over the years. Here’s a roundup of compounds I posted on back last summer, with links to their brutal development histories. I wondered here about what’s going to happen with this class of compounds: will one ever make it as a drug?… Read More
  • Cardiovascular Disease

    Merck’s Tredaptive Comes to a Halt

    Merck’s Tredaptive (formerly Cordaptive) has had a long and troubled history. It’s a combination of niacin and Laropiprant, which is there to try to reduce the cardiovascular (flushing) side effects of large niacin doses, which otherwise seem to do a good job improving lipid profiles. (Mind you, we don’t seem to know how that work… Read More
  • Cardiovascular Disease

    Mipomersen In Trouble

    I wrote here in 2009 about Kynamro (mipomersen), an antisense oligonucleotide from Isis targeted LDL cholesterol levels. At the time, Isis and Genzyme were starting to look at its use in people with familial hypercholesterolaemia, and its prospects looked promising to become at least a profitable niche drug. But the European Medicines Authority jus… Read More
  • Cardiovascular Disease

    Eli Lilly’s Drumbeat of Bad News

    Eli Lilly has been getting shelled with bad news recently. There was the not-that-encouraging-at-all failure of its Alzheimer’s antibody solanezumab to meet any of its clinical endpoints. But that’s the good news, since that (at least according to the company) it showed some signs of something in some patients. We can’t say that a… Read More
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