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  • A Close Look at Protein Head Counts

    So how many proteins are there in a living cell? Not how many different proteins, although that’s a pretty good question all by itself, one that’s b… Read More
  • The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Mu… Read More
  • CRISPR: The Latest Edition

    There’s a rather large breakthrough in CRISPR gene editing – yeah, another one – that has downstream implications for drug discovery. A group… Read More
  • HAT Inhibitors: Interpret With Care

    There are quite a few histone deacetylase inhibitors out there, from research tools to FDA-approved drugs. Those inhibit the enzymes that remove the acetyl epig… Read More
  • Watch Your Covalent Drugs Carefully

    EGFR is a growth-factor receptor protein that’s well known as a cancer target, and there are a number of drugs that target its kinase activity in order to… Read More
  • The Blind Watchmaker’s Workshop

    Did it have to be this way? I mean all of it – biochemistry, the molecules of life. More specifically, as proteins evolve and change, how many paths could… Read More
  • Tagging Fungi For Destruction

    Fungal infections can be very bad news when they go beyond the get-something-from-the-drugstore stage. That fact that a drug as rough as amphotericin B is still… Read More
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