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Posts tagged with "Chemical Biology"

  • Chemical Biology

    Methionine Is Now Your Friend

    I’ve been meaning to mention this new paper, from a mixed Berkeley/UCSF team, which could open up a new area for chemical biology. If you want to label a protein, you have to have a handle to do it. “Label”, in this sense, can mean almost anything. You could be sticking a fluorescent group of… Read More
  • Chemical Biology

    More Spring-Loaded Reagents

    I wrote just about this time last year about a new “strain-release” bond forming reaction system from the Baran group at Scripps. Now they’ve got a good-sized paper in JACS with more reactions in that line, but be warned. If you hit “Print” on the Supporting Information file, you’d better have spare paper, becaus… Read More
  • Chemical Biology

    Curcumin Will Waste Your Time

    I really enjoyed reading this article in J. Med. Chem. on curcumin. (Update: here’s the take over at Practical Fragments). That’s a well-known natural product, found in large quantities in turmeric root (which is where most of the yellow color comes from). It has, over the years, been a hit in many, many assays, and… Read More
  • Chemical Biology

    Nailing Down Small Proteins

    I found this to be a remarkable paper. Making synthetic peptides into drugs has been something that people have been trying for decades now, but it’s a really hard way to make a living. Proteins get degraded. They get degraded in the gut, in the blood, and in every tissue you can name. That may… Read More
  • Chemical Biology

    New Metalloenzymes Made to Order

    Here’s an interesting paper that combines two fields that normally don’t intersection much: protein evolution and organometallic catalysis. That Venn diagram overlaps so sparsely, of course, because the sorts of organometallic chemistry that gets done in labs is largely incompatible with living systems – if you’re handling… Read More
  • Chemical Biology

    Chemical Probes: This Year’s Model

    I wanted to mention that the Chemical Probes portal (mentioned here last summer) has been re-launched with more features, more information (and more funding!) What it needs are more probes in its database. I’ve been submitting some suggestions this morning based on some of my own past experiences, and I invite others to do the same. One… Read More
  • Biological News

    Covalent Fragments Yield A Pile of Information

    What happens when you expose a reactive, covalent-bond-forming compound to cell extracts (or to living cells)? The answer is complicated. You might expect the compound to go around grabbing every reactive group it sees, shotgunning across the proteins it encounters and labeling without discrimination. But it turns out that you only see that with th… Read More
  • Business and Markets

    Chemical Evolution Makes a Deal

    Sanofi has signed a deal with a Stanford-born startup called DiCE Molecules, looking for small-molecule inhibitors of protein-protein interactions. So who are these folks and what route do they have into this perpetually promising-and-challenging area? DiCE grew out of work at Pehr Harbury’s group at Stanford. The company’s web site mak… Read More
  • Chemical Biology

    A New Amine Reaction – In Fact, Several

    I’ve been meaning to write about this new amine-substitution chemistry from the Baran group at Scripps, in collaboration with Pfizer’s labs in La Jolla. It’s a technique that they’re calling “strain-release amination”, because it’s being applied to strained small-ring systems like [1.1.1]bicyclopentaneamin… Read More
  • Analytical Chemistry

    So What Exactly is SCR7?

    Those of you who are into CRISPR will likely have heard for SCR7. It’s a compound added to the system that seems to enhance its efficiency and specificity, presumably through its inhibition of DNA ligase IV. That’s all fine – the mechanism makes sense, and making CRISPR more selective is a worthy goal that any… Read More