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Posts tagged with "Chemical Biology"

  • Chemical Biology

    A New Bioorthogonal Reaction

    I wanted to mention a new bioorthogonal reaction that’s been reported from the Bertozzi lab at Stanford. This one is between N-oxides and diboron compounds, reducing the N-oxide back down to an amine. Since there are many fluorescent tag molecules that have N, N-dialkylamines on their heterocyclic cores, that suggested a way to suddenly make… Read More
  • Chemical Biology

    The Boston DNA Encoded Library Conference

    As mentioned, I’m attending the first Boston symposium on encoded library platforms today. I’m starting this post, which I’ll update during the day as interesting things come up. I thought I’d do a quick introduction to the ideas behind this technology, for those who haven’t been following the field. (That link above a… Read More
  • Chemical Biology

    The Sales Pitch Via the Literature

    In the past weeks, I’ve noticed a couple of papers using the HaloTag system for in vivo chemical biology. Here’s one on target ID (open access, submitted by the manufacturers themselves, Promega), and here’s another from Pfizer on using the system as a platform to compare tools for intracellular imaging. I have no personal experie… Read More
  • Chemical Biology

    The Problems That the Synthesis Machine Won’t Solve

    Martin Burke, a chemist at the University of Illinois, made a big splash some months back with his “synthesis machine”. And I have to confess, I probably helped some of the water fly through the air. I’d heard him talk about this technology, and I was very impressed, and I found the subsequent paper impressive… Read More
  • Biological News

    Chemical Probe Compounds: Time to Get Real

    Update: the chemical probes portal mentioned here has since been updated and re-launched. There’s a new paper on chemical probes out in Nature Chemical Biology, and right off, I have to disclose a conflict of interest. I’m a co-author, and I’m glad to be one. (Here’s a comment at Nature News, and here’s one at… Read More
  • Chemical Biology

    Lipids, Proteins, and Chapman’s Homer

    Longtime readers might recall that every so often I hit on the topic of the “dark matter” of drug target space. We have a lot of agents that hit G-protein coupled receptor proteins, and plenty that inhibit enzymes. Those, though, are all small-molecule binding sites, optimized by evolution to hold on to molecules roughly the… Read More
  • Chemical Biology

    PROTAC Goes Small-Molecule

    Since I mentioned the Bradner lab’s protein-destruction technology recently, I should also highlight this recent paper from Craig Crews and co-workers. In that post, I noted that their PROTAC method has been heading in a small-molecule direction, and this paper certainly confirms that. Instead of the phthalimide (as in the Bradner work), they… Read More
  • Chemical Biology

    Targeting Proteins for Destruction

    Here’s an excellent new paper that’s appeared in the preprint area of Science, Science Express. Jay Bradner and co-workers at Harvard/Dana-Farber report a new way to control protein function, and this one seems both very effective and startlingly simple. The engine of destruction is thalidomide, or (more accurately) the way that the pth… Read More
  • Chemical Biology

    Controlling Proteins, One by One

    Here’s what looks like a very useful method for turning protein function on and off, reported in a new paper in Nature Chemistry. (This PDF link may work for you). The authors, from the MRC Molecular Biology labs at Cambridge (right there on Francis Crick Avenue), have a neat system for optical switching. Here we… Read More
  • Cancer

    Aileron and p53

    In the long-running saga of getting a stapled peptide to work as a drug, Aileron Therapeutics was last heard from raising money for their p53 candidate. Now comes word that the company is basically going all-in with that one, raising yet more cash and gearing up for some definitive human trials. I wish them luck. Read More
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