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Posts tagged with "Chemical News"

  • Chemical News

    A Retrosynthesis Contest

    Here’s a retrosynthesis challenge from Merck KGaA in Darmstadt. They’re celebrating the company’s 350th anniversary, and this is apparently part of the festivities. Anyone can enter for free, and the company will choose up to 12 entrants to take part in the competition itself. As I understand it, each selected person/group will th… Read More
  • Analytical Chemistry

    The Entropic Term is Laughing At Us

    There are plenty of things to optimize in a med-chem project other than binding affinity. But if you don’t have at least some level of binding, you may not have a med-chem project. And while from the outside, you might think that understanding how and why compound A binds to a given target while compound… Read More
  • Analytical Chemistry

    Covalent Organic Frameworks

    Let us pause to consider the weirdness of diamond. Not because diamonds are rare – they’re not, at least compared to many other minerals and gemstones. But diamond itself has very unusual physical properties, and that comes down to its structure. As is well known to chemists, it’s a three-dimensional lattice of bonded sp3 carbons… Read More
  • Chemical News

    Water Isn’t Water Down There

    When I look at the chemical literature now versus what it was like when I was in graduate school, two things stand out: we’re gotten a lot better at looking at single-molecule events and characterizing behavior at a very small scale, and at the same time, we’ve gotten a lot better at detailed characterization of… Read More
  • Chemical News

    A Catalytic Dess-Martin?

    I have not tried this new reaction out, but it could be a real convenience, in several ways, for synthetic organic chemists. The authors, from Texas A&M, had previously reported an air-driven catalytic route to iodine (III) oxidants, and now they extend that work all the way up to iodine (V). The key is generation… Read More
  • Chemical News

    Relay Calculates Its Way Through

    Bloomberg has a feature on Relay Therapeutics, who are just a few blocks away from me (and where several former colleagues of mine work). It’s a nice writeup, and also features a (relatively rare) spotlight on David Shaw of D. E. Shaw research. He’s one of those guys that you’ve likely never heard of unless… Read More
  • Chemical News

    Organic Chemistry on Mars

    We’re going far afield for chemistry news this morning: all the way to Mars. As many readers will have seen, there’s some very interesting (and long-awaited) news – deposits of organic compounds have been conclusively identified. (Here’s the paper, free full text). This really is of great importance, for several reasons, and… Read More
  • Chemical News

    The Huge Landscape of “Just One of Those Things That Happens”

    Why do our reactions fail? Why do our darn reactions fail? Every experimental chemist wonders this, because we all have set up reactions that we thought would work (why else would we run them, eh?) only to have them sit there and do nothing – or worse, do everything and turn the color of used lawnmower… Read More
  • Chemical News

    Ark Pharm’s Shady Side

    Once in a while we have discussions of chemical suppliers around here – but we haven’t had one like this. On Friday afternoon, word came out that Ark Pharm, a reasonably well-known firm out of Chicago, had been raided by the DEA. That becomes abundantly clear if you try to access the company’s web site. Read More
  • Chemical News

    Birch Reactions Without the Ammonia

    The Birch reduction – there’s an old-school synthetic transformation from you. I thought that when I first did one in 1983, so it must be even more so now, right? You condense liquid ammonia and dissolve a reactive metal in it (sodium or lithium are the usual), giving you a rather unexpected blue solution. That… Read More
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