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Posts tagged with "Chemical News"

  • Biological News

    Is Selective Ribosome Stalling Possible? Apparently So

    PCSK9 is a drug target that’s famous in several directions. If you’re interesting in human genetics, it’s famous as an example of a “human knockout” – people with nonfunctional PCSK9, and there are a handful, have extraordinarily low levels of LDL, a finding that immediately got drug companies interested in findi… Read More
  • Chemical Biology

    Nailing Down Small Proteins

    I found this to be a remarkable paper. Making synthetic peptides into drugs has been something that people have been trying for decades now, but it’s a really hard way to make a living. Proteins get degraded. They get degraded in the gut, in the blood, and in every tissue you can name. That may… Read More
  • Chemical News

    Burning In Reverse

    This paper has picked up some coverage and headlines, not all of which are accurate. It’s from a group at Oak Ridge that’s looking at methods to use carbon dioxide as a chemical feedstock, and that’s a worthy goal. If we could usefully turn CO2 back into methanol, methane, or some other such material we… Read More
  • Chemical News

    Molecular Machinery: the 2016 Nobel Prize in Chemistry

    The 2016 Chemistry Nobel has gone to Jean-Pierre Sauvage, J. Fraser Stoddart, and Bernard (Ben) Feringa for their work on molecular-sized machinery. This field has been growing steadily over the last quarter of a century, fueled by advances in synthetic organic techniques, analytical instrumentation, and the imaginations of the people who are pract… Read More
  • Chemical News

    Nobel Season 2016

    It’s Nobel Prize week! This morning we already had the Medicine/Physiology award (Yoshinori Ohsumi, for autophagy), and Chemistry is coming out on Wednesday. As is traditional, we shall now uselessly speculate about who will (or should) win the thing. I’m late to the game this year: here are predictions by Wavefunction, an all-star webi… Read More
  • Chemical News

    A Bucket of Photons

    A lot more people have run photochemistry reactions over the last few years than before, and a lot more people have used flow reactors. Photochemical flow makes a great deal of sense as a combination, too, since one key variable is getting enough photons into your reaction. Setting up a one-liter round bottom is probably… Read More
  • Chemical News

    Let the Catalysts Sort the Catalysts Out

    Here’s something I don’t recall having seen before: letting catalysts dynamically sort themselves out during a reaction. The authors, from the Royal Institute of Technology in Stockholm, are looking at the classic Morita-Baylis-Hillman (MBH) reaction between an aldehyde and an electron-deficient alkene. The traditional catalyst for this… Read More
  • Chemical News

    Predicting New Reactions

    While working on my talk on robotics and artificial intelligence, I was sent a link to this paper (PDF) which I thought was worth a look. It’s from a team at the University of Münster, and what they’re trying to do is look for patterns in the entire corpus of synthetic reactions. They’ve used data… Read More
  • Chemical News

    The New Age of Organic Synthesis

    Earlier this year I wrote about a couple of new coupling methods that use carboxylic acids to alkylate aryl groups. Now there’s another winner to report: the MacMillan group is out with a nickel-catalyzed reaction that does something similar, only it forms aliphatic C-C bonds. This is the sort of reaction that people have been… Read More
  • Chemical News

    Rip Up Your Prolines

    Here’s an interesting paper in the “modify at the last step” genre from Christina White’s group at Illinois (press release here). They’ve been investigating oxidative C-H functionalization by iron species (which takes me back to the days when I used to attend Sir Derek Barton’s consulting sessions at my first job… Read More
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