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Posts tagged with "Chemical News"

  • Chemical News

    Not Even Wrong

    This paper is not going to make a lot of computational chemists very happy at all. It’s from Dan Singleton and Erik Plata at Texas A&M, and it’s on the Morita-Bayliss-Hillman reaction. More specifically, though, it’s on the many computational attempts to decide on the mechanism of the MBH reaction, and taken together, they… Read More
  • Chemical News

    Chemistry Incident in Manchester

    There was some sort of incident at the University of Manchester yesterday. one that led to an evacuation of the chemistry building and all sorts of haz-mat people being called in. Press reports had it that this was a peroxide-acetone mixture that “crystallized”, but you never want to take these things at face value. One… Read More
  • Chemical News

    Our Friend the Sulfur Atom

    Here’s a review on a topic that I’ll bet not too many medicinal chemists have thought about in detail: noncovalent interactions with sulfur atoms. Sulfur’s a weird element – small enough to fit unobtrusively into organic structures, but just big enough to show some orbital effects that you don’t get one row above in th… Read More
  • Chemical News

    Put Away The Lecture Bottle

    For fluorination fans, here’s a new way to get trifluoromethyl groups in. Trifluoromethyl iodide is a useful reagent, or it would be if it weren’t a gas. That makes it annoying to measure out and work with, especially on a small scale. But Tobias Ritter’s lab has a new way to deal with the stuff: Read More
  • Chemical News

    Chlorine Azide For Everyone

    One of my “Things I Won’t Work With” compounds may have moved into a zone where I’d actually use it. This new paper in JOC describes in situ preparation of small amounts of chlorine azide, which can then react with alkene to give useful beta-chloro azide products. This way, you in dilute solution, with slow… Read More
  • Chemical News

    PAINs And Good Old Med Chem

    The mainstreaming of the PAINs concept continues, with editorials from Jonathan Baell in ACS Med. Chem. Letters and Dan Erlanson in J. Med. Chem.. Both are definitely worth a read. Baell emphasizes that real hits tend to have real SAR around them. You can take pieces off the structures, and activity falls away; you can… Read More
  • Chemical News

    Para-Chloro Was Good Enough For Them, So It’s Good Enough For Me

    How many of the molecular pieces that we use in medicinal chemistry are historical accidents? I’ve wondered this from time to time. There’s no doubt that drug structures are partly driven by ease of synthesis/commercial availability (these two go hand in hand), and these in turn are influenced by which reactions and feedstocks were expl… Read More
  • Analytical Chemistry

    Spectra of An Actual Transition State?

    I don’t spend too much time on physical organic chemistry here on the blog, which in a way is a shame. The readership would dwindle, although probably not as much as when I talk about patent law and intellectual property. But physical organic is an area I’ve always enjoyed, intellectually, even though it was sometimes… Read More
  • Chemical News

    What Compound Will You Never Forget?

    While catching up on the literature today, I find that even now, thirty years later, I can’t look at a paper that uses 1,6-anhydroglucose (levoglucosan to its friends) without a quick, simultaneous flicker of interest and shiver of dread. This is why. So fellow chemist, what’s yours? What compound will you never forget, because it… Read More
  • Chemical News

    A Fluorination Review

    Most medicinal chemists like fluorinated compounds, since they tend to give compounds very different (and often more desirable) properties, and we’re interested in new ways of preparing them. The last few years have seen a real upsurge in the synthetic methods available in this area, and particularly in reagents and techniques that can be app… Read More
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