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Posts tagged with "Chemical News"

  • Chemical News

    Eric Betzig Is Not a Chemist, And I Don’t Much Care

    Update: Betzig himself has shown up in the comments to this post, which just makes my day. Yesterday’s Nobel in chemistry set off the traditional “But it’s not chemistry!” arguments, which I largely try to stay out of. For one thing, I don’t think that the borders between the sciences are too clear – you… Read More
  • Biological News

    The 2014 Chemistry Nobel: Beating the Diffraction Limit

    This year’s Nobel prize in Chemistry goes to Eric Betzig, Stefan Hell, and William Moerner for super-resolution fluorescence microscopy. This was on the list of possible prizes, and has been for several years now (see this comment, which got 2 out of the 3 winners, to my 2009 Nobel predictions post). And it’s a worthy… Read More
  • Chemical News

    Meinwald Honored

    It’s been announced today that Jerry Meinwald (emeritus at Cornell) has won the Presidential Medal of Science in chemistry. That’s well deserved – his work on natural product pheromone and signaling systems has had an impact all through chemistry, biology, agricultural science, ecology, and beyond. He and Thomas Eisner totally cha… Read More
  • Chemical News

    A New Reductive Amination

    A colleague brought this new JACS paper to my attention the other day. It’s a complementary method to the classic reductive amination reaction. Instead of an aldehyde and amine (giving you a new alkylated amine), in this case, you use a carboxylic acid and an amine to give you the same product, knocking things down… Read More
  • Chemical News

    2014 Chemistry Nobel Predictions

    Well, we’re getting close to the Nobel season, so it’s time for the yearly “Who’s going to win?” post. According to Thomson Reuters, some favorites are Tan/van Slyke for organic light-emitting diodes, Moad/Rizzardo/Thang for RAFT polymerization, and Kresge/Ryoo/Stucky for mesoporous materials. You can see a real materi… Read More
  • Chemical News

    Thoughts on Fragment-Based Drug Discovery

    I’ve been enjoying the FBLD fragment conference in Basel. There have been many good talks, and it’s been instructive to talk shop with people as well. Some things that various participants (and I) have noted: (1) There are a lot of industry people here, from all over. Fragment-based methods have clearly made a big impression… Read More
  • Analytical Chemistry

    Seaborgium hexacarbonyl

    If you want to really push the frontiers of analytical chemistry, try making compounds of the superheavy elements. Science is reporting the characterization of seaborgium hexacarbonyl, which gives us all a chance to use Sg in an empirical formula. We’re not going to be using it too often, though, because this work was conducted on… Read More
  • Analytical Chemistry

    Weirdly, Tramadol Is Not a Natural Product After All

    Last year I mentioned a paper that described the well-known drug tramadol as a natural product, isolated from a species of tree in Cameroon. Rather high concentrations were found in the root bark, and the evidence looked solid that the compound was indeed being made biochemically. Well, thanks to chem-blogger Quintus (and a mention on… Read More
  • Chemical Biology

    Reactive Groups: Still Not So Reactive

    Just how reactive are chemical functional groups in vivo? That question has been approached by several groups in chemical biology, notably the Cravatt group at Scripps. One particular paper from them that I’ve always come back to is this one, where they profiled several small electrophiles across living cells to see what they might pick… Read More
  • Chemical News

    The Smallest Drugs

    Here is the updated version of the “smallest drugs” collection that I did the other day. Here are the criteria I used: the molecular weight cutoff was set, arbitrarily, at aspirin’s 180. I excluded the inhaled anaesthetics, only allowing things that are oils or solids in their form of use. As a small-molecule organic chemist… Read More
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