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Posts tagged with "Chemical News"

  • Chemical News

    Aminothiazoles: A Yellow Caution Light

    I can agree with this one: “Promiscuous 2-aminothiazoles: A Frequent Hitting Scaffold”. The authors (the med-chem group from Monash University in Australia, with a collaborator from AstraZeneca) make the case that the title compounds are usually more trouble than they’re worth. They noticed that the 4-phenyl derivative went fourte… Read More
  • Chemical News

    Rhodanines Are Even Trickier Than You Thought

    Bad things get said around here about rhodanines. That chemical class tends to hit in a lot of assays, especially assays against hard targets, leading to thoughts like the ones I was expressing the other day and in this post as well.. The problems with these compounds are many (and are mentioned in those blog… Read More
  • Chemical News

    A New Bond-Forming Reaction

    Back to work! I wanted to start out the year of blogging by mentioning a paper that came out in December, before the break. The Baran group at Scripps has extended their very useful olefin coupling method, originally blogged about here. Now it works with a wide variety of heteroatom-substituted double bonds. This, as they… Read More
  • Chemical News

    More Designer Drugs

    Here’s a good article on the illegal recreational drug trade – the boutique end of it, anyway. I’ve written about this sort of thing before, and this piece is squarely in the same territory (even to interviewing David Nichols). It all comes down to this: there are quite a few people out there modifying known… Read More
  • Chemical News

    A New Route to Spiro Heterocycles

    For fans of saturated nitrogen heterocycles (and there are many in med-chem), this paper is well worth a look. It’s from Jeffrey Bode’s group at the ETH in Zürich (authors of a recent review in this area), and it’s another version of their “SnAP” chemistry, tin-mediated conditions for ring formation. Bode and coauthor… Read More
  • Chemical News

    Fast Flow For DARPA

    For you flow chemistry fans, here’s a paper on the flow equivalent of speed chess: a three-minute synthesis and purification of ibuprofen. Three bond-forming steps, one work-up, and one purification all take place in that time, producing about 8g/hour of final product. Notable features include the use of aluminum chloride, which is the sort o… Read More
  • Chemical News

    Try Some Reactions. Actually, Try Them All.

    Here’s a really nice example of high-throughput reaction discovery/condition scouting from a team at Merck. They certainly state the problem correctly: Modern organic synthesis and especially transition metal catalysis is redefining the rules with which new bonds can be forged, however, it is important to recognize that many “solved” synt… Read More
  • Chemical News

    Reaction Discovery Reviewed

    I’ve written several times here about reaction discovery techniques, going back to 2011. And I’ve been meaning to link to this recent review in Nature Chemistry, because it’s an excellent summary of the field and the relevant literature. If you’re at all interested in the topic of combinatorial reaction-searching and new met… Read More
  • Chemical News

    How Are Things at Princeton?

    So how’s the new chemistry building at Princeton working out? I last asked for comments four years ago, but I’m prompted to do so again by this post by Luysii, who has been hearing that the building isn’t necessarily working out as planned. Can anyone comment? To a first approximation, a lot of buildings don’t… Read More
  • Chemical News

    Maitotoxin Marches On

    See Arr Oh brings news that the Nicolaou group has published another piece of maitotoxin. This has been going on for some years now, and looks to go one for a few more. To remind everyone, that’s the structure of maitotoxin. Readers can decide for themselves which parts of the molecule they find most useful… Read More
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