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Posts tagged with "Chemical News"

  • Chemical News

    Stop Ignoring the Sugars!

    This paper (from two groups at Yale’s chemistry department) addresses several important things that fall into the “important irritants” category in synthesis and molecular biology – or maybe that should be “irritatingly important”. We spend a lot of time thinking about proteins in terms of their primary sequence… Read More
  • Chemical Biology

    4-Azidophenylalanine: A Warning

    There’s a reagent used in chemical biology and protein labeling that should be getting a bit more attention than it does. Not because it’s useful – that’s already known – but because it can explode. Here’s the paper (from UC-Irvine and Amgen), and the compound is the 4-azido derivative of phenylalanine. Interest… Read More
  • Chemical News

    Calculate Your Way Out of Bad Yields

    I wrote a little while back about a brute-force approach to finding metal-catalyzed coupling conditions. These reactions have a lot of variables in them and can be notoriously finicky about what combination of these will actually give decent amounts of product. At the same time, it appears that almost any given metal-catalyzed coupling reaction is… Read More
  • Analytical Chemistry

    Mirror Proteins Come Through

    You know, chemistry is kind of a big field. I say that because I’ve been actively reading the chemical literature for over thirty years now, and I still keep running across topics that I never knew existed. One of these popped up the other day: racemic protein crystallography. Now there may be a few readers… Read More
  • Chemical News

    More Thoughts of George Whitesides – And of Phil Baran

    The other day I wrote up some comments about a recent article from George Whitesides. If you’ve heard him speak on the topic of organic synthesis, you’ve probably heard most of what’s in that piece, but it’s a good summary of his position. Picked up roughly where I left off last time, he has this… Read More
  • Chemical News

    The Thoughts of George Whitesides, Part I

    A number of readers have mentioned this new paper by George Whitesides on organic synthesis. I can state as a fact that the first time I heard a joking reference to his attitude towards traditional synthetic organic chemistry was in the summer of 1983, so it’s not like he’s been keeping his thoughts bottled up. Read More
  • Chemical Biology

    21st Century Enzymes

    Here’s a remarkable paper that shows how enzymes can be engineered to turn out some very unnatural-looking structures. Frances Arnold’s group at CalTech has published on some work in this area in the past, and this latest variation is something t0 see. They’ve been working with various heme proteins, since that reactive center is… Read More
  • Analytical Chemistry

    More on Crystal Formation (This Time With Proteins)

    I realize that I was just talking about crystal formation here the other day, but there’s yet more news in the area, and it comes in the fiendishly difficult area of protein crystallography. All you have to do to appreciate the horrors of this field is to step into a lab that does it for… Read More
  • Chemical Biology

    New Chemistry, And Its Limits

    Here’s an article in Nature Chemistry on organic synthesis and drug discovery, from a distinguished group of drug-industry chemists. The authors are going over a number of areas where medicinal chemistry could make use of more advanced synthetic techniques, and they’re good ones. For example, “From an industry perspective, the mos… Read More
  • Chemical News

    The Rise of the Rise of the Machines

    There’s yet another paper on computer-devised retrosynthesis out today – it and the previous one make an interesting pair. I have a Nature “New and Views” comment on this one (free access link) for a broader audience, but I’ll expand on my thoughts here. (Update: I’m also going on about this on a Nature podcast… Read More
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