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Posts tagged with "Chemical News"

  • Chemical News

    Relay Calculates Its Way Through

    Bloomberg has a feature on Relay Therapeutics, who are just a few blocks away from me (and where several former colleagues of mine work). It’s a nice writeup, and also features a (relatively rare) spotlight on David Shaw of D. E. Shaw research. He’s one of those guys that you’ve likely never heard of unless… Read More
  • Chemical News

    Organic Chemistry on Mars

    We’re going far afield for chemistry news this morning: all the way to Mars. As many readers will have seen, there’s some very interesting (and long-awaited) news – deposits of organic compounds have been conclusively identified. (Here’s the paper, free full text). This really is of great importance, for several reasons, and… Read More
  • Chemical News

    The Huge Landscape of “Just One of Those Things That Happens”

    Why do our reactions fail? Why do our darn reactions fail? Every experimental chemist wonders this, because we all have set up reactions that we thought would work (why else would we run them, eh?) only to have them sit there and do nothing – or worse, do everything and turn the color of used lawnmower… Read More
  • Chemical News

    Ark Pharm’s Shady Side

    Once in a while we have discussions of chemical suppliers around here – but we haven’t had one like this. On Friday afternoon, word came out that Ark Pharm, a reasonably well-known firm out of Chicago, had been raided by the DEA. That becomes abundantly clear if you try to access the company’s web site. Read More
  • Chemical News

    Birch Reactions Without the Ammonia

    The Birch reduction – there’s an old-school synthetic transformation from you. I thought that when I first did one in 1983, so it must be even more so now, right? You condense liquid ammonia and dissolve a reactive metal in it (sodium or lithium are the usual), giving you a rather unexpected blue solution. That… Read More
  • Analytical Chemistry

    Organometallic Oddities

    Synthetic organic chemists spend a lot of time using organometallic coupling reactions, because they can be such great ways to make carbon-carbon (and carbon-heteroatom) bonds. And that’s the currency of the realm: do you want to build up larger molecules from smaller precursors in a controlled fashion? You’re going to have to make bond… Read More
  • Chemical News

    A Closed Loop

    This is not a paper that’s going to make everyone who reads it happy, but it needs to be read anyway. A collaboration between the University of Helsinki, LifeArc (which looks to be one of the small companies in the former Stevenage pharma campus) and Cyclofluidic reports development of inhibitors against hepsin, a serine protease… Read More
  • Analytical Chemistry

    Clicked DNA: From Lab Curiosity to Analytical Technique

    I’ve written a few times about an odd sort of unnatural DNA sequence, where some of the nucleotides are connected via “click” triazole units rather than the traditional polyphosphate backbone. I remember wondering what the chemical biology community would make out of these things, and I wanted to report on at least one ingenious a… Read More
  • Chemical News

    Silicon In Drug Molecules, Revisited

    Here’s an update to a post from last year about silicon in drug-like molecules. The Denmark group at Illinois has investigated a range of silicon-containing heterocycles, providing both synthetic routes into the (mostly unknown) structures, and looking at some basic pharmaceutically relevant properties. There’s a lot of work in this pap… Read More
  • Chemical News

    Diazos On Demand

    I don’t think that anyone really likes diazomethane. Organic chemists like what it can do (cyclopropane formation, cycloadditions, fast, clean methyl ester formation, etc.), but the compound itself is very hard to have warm feelings for. It’s unstable on storage, and thus has to be prepared fresh. That preparation is fairly tedious, and… Read More
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