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Posts tagged with "Chemical News"

  • Chemical News

    ChemDraw on the iPad

    If you’re in iPad sort of chemist (one of Baran’s customers?), you may well already know that app versions of ChemDraw and Chem3D came out yesterday for that platform. I haven’t tried them out myself, not (yet) being a swipe-and-poke sort of guy, but at $10 for the ChemDraw app (and Chem3D for free), it… Read More
  • Chemical News

    The Flip Side: Organic Chemistry That Should Be More Famous

    I see that Neil Withers is trying to start up a new discussion in that “Kudzu of Chemistry” comment thread. The main topic is what reactions and chemistry we see too much of, but he’s wondering what we should see more of. It’s a worthwhile question, but I wonder if it’ll be hard to answer. Read More
  • Chemical News

    The Current Kudzu of Chemistry?

    Chemistry, like any other human-run endeavor, goes through cycles and fads. At one point in the late 1970s, it seemed as if half the synthetic organic chemists in the world had made cis-jasmone. Later on, a good chunk of them switched to triquinane synthesis. More recently, ionic liquids were all over the literature for a… Read More
  • Chemical News

    A Total Synthesis Archive

    For those who are into total synthesis of natural products, Arash Soheili has a Twitter account (Total_Synthesis) that keeps track of all the reports in the major journals. He’s emailed me with a link to a searchable database of all these, which brings a lot of not-so-easily-collated information together into one place. Have a look! Read More
  • Analytical Chemistry

    Check Out These Molecules

    It’s molecular imaging week! See Arr Oh and others have sent along this paper from Science, a really wonderful example of atomic-level work. (For those without journal access, Wired and PhysOrg have good summaries). As that image shows, what this team has done is take a starting (poly) phenylacetylene compound and let it cyclize to… Read More
  • Chemical News

    Making the Non-Flat, Non-Aromatic Compounds

    Here’s a question for the organic chemists in the crowd, and not just those in the drug industry, either. Over the last few years, though, there’s been a lot of discussion about how drug company compound libraries have too many compounds with too many aromatic rings in them. Here are some examples of just the… Read More
  • Chemical News

    A New Way to Determine Chirality

    There’s a new paper out today in Nature on a very unusual way to determine the chirality of organic molecules. It uses an exotic effect of microwave spectroscopy, and I will immediately confess that the physics is (as of this morning, anyway) outside my range. This is going to be one of those posts that… Read More
  • Chemical News

    Alkynes and Nitriles

    Put this one in the category of “reactions you probably wouldn’t have thought of”. There’s a new paper in Organic Letters on cleaving a carbon-carbon triple bond, yielding the two halves as their own separate nitriles. It seems to be a reasonable reaction, and someone may well find a use for it. I just enjoyed… Read More
  • Academia (vs. Industry)

    GSK’s Published Kinase Inhibitor Set

    Speaking about open-source drug discovery (such as it is) and sharing of data sets (such as they are), I really should mention a significant example in this area: the GSK Published Kinase Inhibitor Set. (It was mentioned in the comments to this post). The company has made 367 compounds available to any academic investigator working… Read More
  • Chemical News

    Pyrrolidines, Not the Usual Way

    I wanted to mention a new reaction that’s come out in a paper in Science. It’s from the Betley lab at Harvard, and it’s a new way to make densely substituted saturated nitrogen heterocycles (pyrrolidines, in particular). You start from a four-carbon chain with an azide at one end, and you end up with a… Read More