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Posts tagged with "Chemical News"

  • Chemical News

    The Old Days in Organic Chemistry

    A look back at the way it used to be, courtesy of ChemTips. What did you do without NMR, without LC-mass spec? You tried all kinds of tricks to get solids that you could recrystallize, and liquids that you could distill. I missed out on that era of chemistry, and most readers here can say… Read More
  • Chemical News

    Cesium, Uh, Trifluoride?

    Here’s a very surprising idea that looks like it can be put to an experimental test. Mao-Sheng Miao (of UCSB and the Beijing Computational Sciences Research Center) has published a paper suggesting that under high-pressure conditions, some elements could show chemical bonding behavior involving their inner-shell electrons. Specific prediction… Read More
  • Biological News

    Fred Sanger, 1918-2013

    Double Nobelist Frederick Sanger has died at 95. He is, of course, the pioneer in both protein and DNA sequencing, and he lived to see these techniques, revised and optimized beyond anyone’s imagining, become foundations of modern biology. When he and his team determined the amino acid sequence of insulin in the 1950s, no one… Read More
  • Chemical News

    In Praise of Organic Chemistry

    Here’s something that you don’t see every day: an article in the New York Times praising the sophomore organic chemistry course. It’s from the Education section, and it’s written from the author’s own experience: Contemplating a midlife career change from science writer to doctor, I spent eight months last year at Harv… Read More
  • Chemical News

    More Magic Methyls, Please

    Medicinal chemists have long been familiar with the “magic methyl” effect. That’s the dramatic change in affinity that can be seen (sometimes) with the addition of a single methyl group in just the right place. (Alliteration makes that the phrase of choice, but there are magic fluoros, magic nitrogens, and others as well). The met… Read More
  • Chemical News

    Getting van der Waals Forces Right

    I’m actually going to ignore the headline on this article at Chemistry World, although coming up with it must have made someone’s day. Once I’d gotten my head back up out of my hands and read the rest of the piece, it was quite interesting. It’s a summary of this paper in Nature Chemistry, which… Read More
  • Chemical News

    Diazomethane Without Tears. Or Explosions.

    Here’s a neat paper from Oliver Kappe’s group on diazomethane flow chemistry. They’re using the gas-permeable tube-in-tube technique (as pioneered by Steve Ley’s group). Flow systems have been described for using diazomethane before, but this looks like a convenient lab-scale method. Diazomethane is the perfect reagent to ap… Read More
  • Chemical News

    Microwave Synthesis

    I wanted to mention a new blog, Totally Microwave, that’s set up to cover all sorts of developments in microwave-assisted chemistry. Full disclosure: it’s from a former colleague of mine. I don’t know of another site that’s working this area, so it could be a good addition to the list – have a look! Read More
  • Chemical News

    Unpacking a JACS Total Synthesis Paper

    If you’re in the mood for some truly 100-proof synthetic organic chemistry, this post from Mark Peczuh at UConn is going to be just what you need. He’s going through the 2002 synthesis of ingenol from the Winkler group, line by line, in an effort to show his own students how to read such highly… Read More
  • Chemical News

    The 2013 Nobel Prize in Chemistry

    The 2013 Nobel Prize in Chemistry has gone to Martin Karplus of Harvard, Michael Levitt of Stanford, and Arieh Warshel of USC. This year’s prize is one of those that covers a field by recognizing some of its most prominent developers, and this one (for computational methods) has been anticipated for some time. It’s good… Read More