Skip to Content

Posts tagged with "Chemical News"

  • Chemical News

    Down At the Crystal Surface

    If you’re at all involved in producing solid forms of compounds, you’re familiar with the concept of a polymorph. That, put simply, is a different crystalline form, and any given substance can have several. Or a lot more than several. I don’t know what the record is for any single compound, but it’s way up… Read More
  • Chemical News

    Single Atoms, On Demand

    We chemists spend a lot of time doing things in the solution phase. It makes sense – if you want things to react, getting all the partners dissolved in some medium where they can roam around and contact each other is surely the way to go, most of the time. But it’s also true that… Read More
  • Biological News

    Alarmingly Functional Disorder

    Let’s think for a bit about how proteins bind to each other. After all, messing around with that is what keeps everyone in the drug industry employed, and the unmessed varieties of such binding events are what keep us all vertical and above room temperature, so it’s a worthy subject. The mental picture is of… Read More
  • Chemical News

    Graphene Continues to Surprise

    I wanted to mention something on the border between chemistry and physics that might well turn out to be important. Graphene (single-layer graphite, a two-dimensional carbon sheet of fused aromatic rings) has been a hot topic for some years, but this will make it a hotter one. It is an absolute requirement that every time… Read More
  • Chemical News

    Crystals Via Lasers

    Crystallization is voodoo. I have not changed my opinion one bit since this 2015 post – if anything, I’m more convinced than ever. We chemists tend to talk about such fields with some pride, because we have to deal with them by our hard work and our wits, but when you get right down to… Read More
  • Chemical News

    Retrosynthesis: Here It Comes

    Behold the rise of the machines. It’s been going on for a while, but there are landmarks along the way, and we may have just passed another one with the publication of this paper. It’s open-access,  from an interestingly mixed team: the Polish Academy of Science, Northwestern University, the University of Warsaw, the Ulsan Institute i… Read More
  • Analytical Chemistry

    Way Down There in the Pores

    Let’s get physical-organic. A big topic of research in recent years has been the properties of liquids and solids under boundary conditions. By that sweeping statement, I mean questions such as “When does a small cluster of metal atoms start to act like a small piece of bulk metal? Why is there a transition, and… Read More
  • Analytical Chemistry

    PAINs by X-Ray

    It’s safe to say that the concept of “pan-assay interference compounds” evokes some strong feelings in medicinal chemists. And those feelings run in several directions: some people are very glad to have a tool with which to winnow down their screening hit lists (or at least to prioritize them), while others are infuriated by the… Read More
  • Chemical News

    Brute Force: Bring On the Machines!

    Well, here I was the other day going on about automated chemistry when this paper was waiting in my RSS feed. It’s from a group at Pfizer, and they’re using an automated microscale flow chemistry rig for reaction optimization. Inspired by this work from Merck, which demonstrated evaluation of 1536 reactions in a plate-based system… Read More
  • Analytical Chemistry

    Tickling Individual Bonds

    When you get down to it, most of the ways that we chemists have to make our reactions work are not very elegant. We can change solvents, mess with ligands, drip A into B slowly instead of B into A, etc. But we’re still depending on the molecules involved just running into each other. We… Read More