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Posts tagged with "Chemical News"

  • Chemical News

    The Ideal Synthesis

    Phil Baran of Scripps has a paper out on the “ideal synthesis” of complex molecules. It’s mostly a review of a number of his group’s own syntheses, but it’s done in light of his definition of “ideal”: all bond-forming steps, with no protecting group manipulations or oxidation-state maneuvering. That’s… Read More
  • Chemical News

    Maitotoxin: It’s On, All Right

    Earlier this year we had a paper from the Nicolaou lab on the synthesis of the ABCDEFG ring system of maitotoxin. Now I see that a synthesis of the QRSTU domain has arrived. That’s what, twelve rings down? Only twenty more to go, guys. This piece is “. . . appropriately functionalized . . . Read More
  • Chemical News

    Sparteine and Other Fine Chemical Shortages

    One of the folks over at Chemistry Blog has run into a shortage: he and his labmates have tried to order (-) sparteine from every supplier in the book, and there’s none to be had. So if anyone has a big dusty bottle of it sitting around, you might drop these desperate chemists a line. Read More
  • Chemical News

    Max Gergel’s Memoirs

    For once, I’m going to farm out a “Things I Won’t Work With” post to someone else. For those who missed it in the comments, here’s the link to the PDF of Max Gergel’s extraordinary memoir “Excuse Me Sir, Would You Like to Buy a Kilo of Isopropyl Bromide?” Gergel founded Columbia Organic Chemicals, and… Read More
  • Chemical News

    What’s the Condensation Record?

    There are probably some other reactions of the same order as this one – but does anyone know a higher one? I’m talking about this four-component condensation reaction, reported from a lab in Iran, which actually makes semi-useful looking oxadiazoles. Anyone know of a five-component condensation? A real one, I mean, that makes a real… Read More
  • Chemical News

    Pyridines and Dichloromethane

    Here’s a quick warning for the bench chemists in the crowd: look out if you’re making pyridines and using dichloromethane as solvent. This paper reports that the two can react, forming bis-pyridinium compounds – which isn’t too surprising, in theory. What’s alarming is that this happens at an appreciable rate at room t… Read More
  • Chemical News

    You Don’t See Many Names Starting with “Tellura-“

    When I wrote here about unknown compounds, using aza-steroids as examples, I apparently wasn’t thinking far enough afield. I noticed this new paper on a new class of tellura-steroids. I’ve no doubt that they’re new; probably no one has ever thought to make anything that looks quite like this before (there’s one other report… Read More
  • Chemical News

    Maitotoxin Revisited

    Last year I wrote about the hideous structure of maitotoxin, with a note about how various groups were kicking around synthetic approaches to it. Now K. C. Nicolaou has a paper out in JACS on the synthesis of a portion of the molecule, which includes the line: “. . .as a prelude to a possible… Read More
  • Chemical News

    Report from C&E News

    Well, the first thing I can tell everyone is that I think the entire editorial staff at Chemical and Engineering News read every comment to this post. And that includes the nasty ones, for sure. The readership around here is a self-selected lot, and the commentors even more so, but the quick volume of responses… Read More
  • Chemical News

    Nonsense About LSD

    The Daily Telegraph in the UK has a story today claiming that a 1951 outbreak of hallucinations and dementia in the French village of Pont-Saint-Esprit was not (as everyone thought) an example of ergot poisoning. No, according to some guy who’s writing a book, it was. . .a secret LSD experiment. Now, there most certainly… Read More
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