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Posts tagged with "Chemical News"

  • Biological News

    The Motions of a Protein

    So, people like me spend their time trying to make small molecules that will bind to some target protein. So what happens, anyway, when a small molecule binds to a target protein? Right, right, it interacts with some site on the thing, hydrogen bonds, hydrophobic interactions, all that – but what really happens? That’s surprisingly… Read More
  • Biological News

    Grabbing Onto A Protein’s Surface

    I’ve written here before about the “click” triazole chemistry that Barry Sharpless’s group has pioneered out at Scripps. This reaction has been finding a lot of uses over the last few years (try this category for a few, and look for the word “click”). One of the facets I find most interesting is the way… Read More
  • Chemical News

    Your Paper Is A Sack Of Raving Nonsense. Thank You.

    You don’t often get to see the sort of fistfight that’s detailed in the latest issue of Organic Process Research and Development. Patents whose procedures are hard to reproduce are familiar to every industrial chemist, unfortunately, but coming across one that seems completely mistaken in its most important details is rare. And this is the… Read More
  • Blog Housekeeping

    Hexacyclinol – Another Request

    I’m taking the day off from cranking out the medicines of tomorrow (OK, the day after tomorrow), so there will be no post today. I did want to add something about yesterday’s post on the La Clair/hexacyclinol controversy. I’d like to ask that people not fill up the comments with ad hominem remarks or potentially… Read More
  • Chemical News

    Hexacyclinol: A Forensic Case

    Remember hexacyclinol? Some readers are probably groaning and thinking “Oh, yes, indeed”, which may make up for the ones who are saying “Remember what?” Hexacyclinol is a complex natural product, but after that statement the arguing begins. James La Clair published a synthesis of it in 2006 in Angewandte Chemie, one of the most prestigious… Read More
  • Chemical News

    The Original Nanotechnology

    Organic chemists, my tribe, have accomplished a lot. But we’ve managed to convince people that we’ve accomplished even more than we have. The general assumption seems to be that we can pretty much make anything, given enough effort. Considering some of the awful molecules that have been made, I can see where that opinion comes… Read More
  • Chemical News

    A Long Tail Indeed

    A reader reminded me of this paper, which I meant to blog on when it came out last year. The authors looked over the entire Chemical Abstracts Service registry file – in theory, every compound that’s ever been reported in the chemical literature – and asked how many different chemical scaffolds make up the organic… Read More
  • Chemical News

    The Real Hazards of the Lab

    A run of bad accident news today, and all of the same kind. The Chemistry Blog has the story of a fatality in the labs at UCLA. The short and painful details are: inexperienced student, t-butyllithium, flammable clothing, and panic (as in not running toward the safety shower). This is very sad to hear about… Read More
  • Analytical Chemistry

    The Great Acetonitrile Shortage

    Now here’s a news item that I’m pretty sure you haven’t heard about unless you work in or near a laboratory. We’re in the middle of an extreme shortage of acetonitrile, a common solvent. This has been going on since back in the fall, but instead of gradually getting better, it’s been gradually getting worse: Read More
  • Chemical News

    Diversity-Oriented Synthesis: Oriented The Right Way?

    Ever hear of Diversity-Oriented Synthesis? It’s an odd bird. DOS tries to maximize the number of structures and scaffolds produced from a given synthetic scheme – to find the most efficient ways to populate the largest amount of chemical space. In a way, it’s the contrapositive of natural product synthesis, which focuses all its effort… Read More