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Posts tagged with "Chemical News"

  • Chemical News

    Maitotoxin Revisited

    Last year I wrote about the hideous structure of maitotoxin, with a note about how various groups were kicking around synthetic approaches to it. Now K. C. Nicolaou has a paper out in JACS on the synthesis of a portion of the molecule, which includes the line: “. . .as a prelude to a possible… Read More
  • Chemical News

    Report from C&E News

    Well, the first thing I can tell everyone is that I think the entire editorial staff at Chemical and Engineering News read every comment to this post. And that includes the nasty ones, for sure. The readership around here is a self-selected lot, and the commentors even more so, but the quick volume of responses… Read More
  • Chemical News

    Nonsense About LSD

    The Daily Telegraph in the UK has a story today claiming that a 1951 outbreak of hallucinations and dementia in the French village of Pont-Saint-Esprit was not (as everyone thought) an example of ergot poisoning. No, according to some guy who’s writing a book, it was. . .a secret LSD experiment. Now, there most certainly… Read More
  • Chemical News

    Flowing, Not So Gently

    I’ve written both here and elsewhere about flow chemistry, the technique where you pump your reactions through a reaction tube of some sort rather than mixing them up in a flask. And I freely admit that I have a fondness for the idea, but it’s definitely not the answer to every problem. For one thing… Read More
  • Chemical News

    Together At Last

    Well, I have no particular need to make azo-linked compounds (see this morning’s post for one reason!). And I have to say, although it’s mechanistically interesting, I definitely feel no desire to make them by combining a hydroperoxide and a diazonium salt in one pot. This is not a moment destined to take its place… Read More
  • Analytical Chemistry

    Sure About That?

    There was a natural products paper (abstract) that I missed last fall which has finally come out in Bioorganic and Medicinal Chemistry Letters. Let’s have a show of hands: how many chemists out there think that this structure is the correct one? Right. Going back through SciFinder, I don’t find any anti-Bredt cyclobutene structures of… Read More
  • Analytical Chemistry

    More Binding Site Weirdness

    Now here’s an oddity: medicinal chemists are used to seeing the two enantiomers (mirror image compounds, for those outside the field) showing different activity. After all, proteins are chiral, and can recognize such things – in fact, it’s a bit worrisome when the enantiomers don’t show different profiles against a protein t… Read More
  • Chemical News

    K. C. Nicolaou, Call Your Office

    While I’m putting up odd chemical structures today, I thought I’d add this one, Alasmontamine A, from the latest Organic Letters preprint stream. Natural products scare me: Anyone who wants to take a crack at this one synthetically, you just go right ahead without me. It is pretty much a dimer, though, so it’s only… Read More
  • Chemical News

    Hoist, Petard, Etc.

    Hmmm. As a colleague just pointed out to me, I’ve spent some time here defending “me-too” drugs. And just this morning (see the previous post) I take off after what can only be described as “me-too reactions”, saying that I don’t see the use for so many of them. Well! The only defense I can… Read More
  • Chemical News

    Retire These Reactions!

    Here’s a question you don’t hear discussed very often: are there some synthetic organic chemistry reactions that don’t need any more work? I’m moved to ask this because I just came across yet another way that someone has reported to dehydrate an oxime to a nitrile. (No, I won’t link to it. You don’t need… Read More
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